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Summary Expression Phenotypes Gene Literature (550) GO Terms (6) Nucleotides (309) Proteins (58) Interactants (2147) Wiki
XB--485219

Papers associated with otx2 (and Disease Ontology)



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A critical role of Pax6 in alcohol-induced fetal microcephaly., Peng Y, Yang PH, Ng SS, Wong OG, Liu J, He ML, Kung HF, Lin MC., Neurobiol Dis. July 1, 2004; 16 (2): 370-6.

Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels., Yelin R, Schyr RB, Kot H, Zins S, Frumkin A, Pillemer G, Fainsod A., Dev Biol. March 1, 2005; 279 (1): 193-204.                  

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos., Tao Q, Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J., Cell. March 25, 2005; 120 (6): 857-71.            

Dystroglycan is required for proper retinal layering., Lunardi A, Cremisi F, Dente L., Dev Biol. February 15, 2006; 290 (2): 411-20.            

Early molecular effects of ethanol during vertebrate embryogenesis., Yelin R, Kot H, Yelin D, Fainsod A., Differentiation. June 1, 2007; 75 (5): 393-403.                    

A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival., Rauschenberger K, Schöler K, Sass JO, Sauer S, Djuric Z, Rumig C, Wolf NI, Okun JG, Kölker S, Schwarz H, Fischer C, Grziwa B, Runz H, Nümann A, Shafqat N, Kavanagh KL, Hämmerling G, Wanders RJ, Shield JP, Wendel U, Stern D, Nawroth P, Hoffmann GF, Bartram CR, Arnold B, Bierhaus A, Oppermann U, Steinbeisser H, Zschocke J., EMBO Mol Med. February 1, 2010; 2 (2): 51-62.                        

Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation., Liu JT, Yang Y, Guo XG, Chen M, Ding HZ, Chen YL, Chen YL, Wang MR., Dongwuxue Yanjiu. October 1, 2011; 32 (5): 485-91.            

Maternal xNorrin, a canonical Wnt signaling agonist and TGF-β antagonist, controls early neuroectoderm specification in Xenopus., Xu S, Cheng F, Liang J, Wu W, Zhang J., PLoS Biol. January 1, 2012; 10 (3): e1001286.                                    

Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye., Atkinson-Leadbeater K, Hehr CL, McFarlane S., Dev Dyn. May 1, 2014; .              

Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character., Fish MB, Nakayama T, Fisher M, Hirsch N, Cox A, Reeder R, Carruthers S, Hall A, Stemple DL, Grainger RM., Dev Biol. November 15, 2014; 395 (2): 317-330.                  

Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway., Amado NG, Predes D, Fonseca BF, Cerqueira DM, Reis AH, Dudenhoeffer AC, Borges HL, Mendes FA, Abreu JG., J Biol Chem. December 19, 2014; 289 (51): 35456-67.                  

Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development., Neilson KM, Abbruzzesse G, Kenyon K, Bartolo V, Krohn P, Alfandari D, Alfandari D, Moody SA., Dev Biol. January 15, 2017; 421 (2): 171-182.                    

Mouth development., Chen J, Jacox LA, Saldanha F, Sive H., Wiley Interdiscip Rev Dev Biol. September 1, 2017; 6 (5):               

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates., Plouhinec JL, Medina-Ruiz S, Borday C, Bernard E, Vert JP, Eisen MB, Harland RM, Monsoro-Burq AH., PLoS Biol. October 19, 2017; 15 (10): e2004045.                                              

HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns., Pai VP, Pietak A, Willocq V, Ye B, Shi NQ, Levin M., Nat Commun. March 8, 2018; 9 (1): 998.                        

Nosip functions during vertebrate eye and cranial cartilage development., Flach H, Krieg J, Hoffmeister M, Dietmann P, Reusch A, Wischmann L, Kernl B, Riegger R, Oess S, Kühl SJ., Dev Dyn. September 1, 2018; 247 (9): 1070-1082.                

WDR5 regulates left-right patterning via chromatin-dependent and -independent functions., Kulkarni SS, Khokha MK., Development. November 28, 2018; 145 (23):                 

Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis., Harata A, Hirakawa M, Sakuma T, Yamamoto T, Hashimoto C., Dev Growth Differ. February 1, 2019; 61 (2): 186-197.                                

Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor., Jalvy S, Veschambre P, Fédou S, Rezvani HR, Thézé N, Thiébaud P., Dev Biol. March 15, 2019; 447 (2): 200-213.                                  

BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers., Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA, Rodriguez DA, King ML, Harbour JW., Sci Adv. September 18, 2019; 5 (9): eaax1738.        

Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics., Pai VP, Adams DS., Bioelectricity. December 1, 2019; 1 (4): 260-272.

MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs., Alwin Prem Anand A, Alvarez-Bolado G, Wizenmann A., Front Cell Dev Biol. January 1, 2020; 8 586158.  

Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development., Shah AM, Krohn P, Baxi AB, Tavares ALP, Sullivan CH, Chillakuru YR, Majumdar HD, Neilson KM, Moody SA., Dis Model Mech. March 3, 2020; 13 (3):                                               

Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis., Lokapally A, Neuhaus H, Herfurth J, Hollemann T., Cells. July 20, 2020; 9 (7):                                           

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis., Chen M, Amado N, Tan J, Reis A, Ge M, Abreu JG, He X., Elife. September 14, 2020; 9                                                                                           

Establishing embryonic territories in the context of Wnt signaling., Velloso I, Maia LA, Amado NG, Reis AH, He X, Abreu JG., Int J Dev Biol. January 1, 2021; 65 (4-5-6): 227-233.      

Xenopus leads the way: Frogs as a pioneering model to understand the human brain., Exner CRT, Willsey HR., Genesis. February 1, 2021; 59 (1-2): e23405.          

Rab11fip5 regulates telencephalon development via ephrinB1 recycling., Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO., Development. February 2, 2021; 148 (3):                                                             

Molecular mechanisms of hearing loss in Nager syndrome., Maharana SK, Saint-Jeannet JP., Dev Biol. August 1, 2021; 476 200-208.            

Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells., Okuno H, Okano H., Regen Ther. August 24, 2021; 18 275-280.      

Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly., Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A., Front Cell Dev Biol. January 1, 2022; 10 844619.                        

The Ribosomal Protein L5 Functions During Xenopus Anterior Development Through Apoptotic Pathways., Schreiner C, Kernl B, Dietmann P, Riegger RJ, Kühl M, Kühl SJ., Front Cell Dev Biol. January 1, 2022; 10 777121.                        

Functions of block of proliferation 1 during anterior development in Xenopus laevis., Gärtner C, Meßmer A, Dietmann P, Kühl M, Kühl SJ., PLoS One. August 2, 2022; 17 (8): e0273507.                        

TBC1D32 variants disrupt retinal ciliogenesis and cause retinitis pigmentosa., Bocquet B, Borday C, Erkilic N, Mamaeva D, Donval A, Masson C, Parain K, Kaminska K, Quinodoz M, Perea-Romero I, Garcia-Garcia G, Jimenez-Medina C, Boukhaddaoui H, Coget A, Leboucq N, Calzetti G, Gandolfi S, Percesepe A, Barili V, Uliana V, Delsante M, Bozzetti F, Scholl HP, Corton M, Ayuso C, Millan JM, Rivolta C, Meunier I, Perron M, Kalatzis V., JCI Insight. November 8, 2023; 8 (21):                                               

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis., Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl SJ., Front Cell Dev Biol. January 1, 2024; 12 1316048.                            

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