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Summary Expression Phenotypes Gene Literature (84) GO Terms (6) Nucleotides (95) Proteins (54) Interactants (861) Wiki
XB-GENEPAGE-485516

Papers associated with lef1



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Functional interaction of beta-catenin with the transcription factor LEF-1., Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W., Nature. August 15, 1996; 382 (6592): 638-42.

Nuclear localization of beta-catenin by interaction with transcription factor LEF-1., Huber O, Korn R, McLaughlin J, Ohsugi M, Herrmann BG, Kemler R., Mech Dev. September 1, 1996; 59 (1): 3-10.

The HMG-box mitochondrial transcription factor xl-mtTFA binds DNA as a tetramer to activate bidirectional transcription., Antoshechkin I, Bogenhagen DF, Mastrangelo IA., EMBO J. June 2, 1997; 16 (11): 3198-206.

The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer., Laurent MN, Blitz IL, Hashimoto C, Rothbächer U, Cho KW., Development. December 1, 1997; 124 (23): 4905-16.

LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter., McKendry R, Hsu SC, Harland RM, Grosschedl R., Dev Biol. December 15, 1997; 192 (2): 420-31.            

Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development., Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destrée O., Mech Dev. July 1, 1998; 75 (1-2): 151-4.          

A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation., Lee YJ, Swencki B, Shoichet S, Shivdasani RA., J Biol Chem. January 15, 1999; 274 (3): 1566-72.  

The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis., Vleminckx K, Vleminckx K, Kemler R, Hecht A., Mech Dev. March 1, 1999; 81 (1-2): 65-74.    

XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development., Brannon M, Brown JD, Bates R, Kimelman D, Moon RT., Development. June 1, 1999; 126 (14): 3159-70.                  

Maternal and embryonic expression of zebrafish lef1., Dorsky RI, Snyder A, Cretekos CJ, Grunwald DJ, Geisler R, Haffter P, Moon RT, Raible DW., Mech Dev. August 1, 1999; 86 (1-2): 147-50.

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1., Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D., EMBO J. August 2, 1999; 18 (15): 4233-40.

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin., Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE., Mol Cell. October 1, 1999; 4 (4): 487-98.                

Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling., Klymkowsky MW, Williams BO, Barish GD, Varmus HE, Vourgourakis YE., Mol Biol Cell. October 1, 1999; 10 (10): 3151-69.

Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates., Moriguchi T, Kawachi K, Kamakura S, Masuyama N, Yamanaka H, Matsumoto K, Kikuchi A, Nishida E., J Biol Chem. October 22, 1999; 274 (43): 30957-62.        

Tcf/Lef transcription factors during T-cell development: unique and overlapping functions., Staal FJ, Clevers H., Hematol J. January 1, 2000; 1 (1): 3-6.

New steps in the Wnt/beta-catenin signal transduction pathway., Sakanaka C, Sun TQ, Williams LT., Recent Prog Horm Res. January 1, 2000; 55 225-36.

LiCl disrupts axial development in mouse but does not act through the beta-catenin/Lef-1 pathway., Rogers I, Varmuza S., Mol Reprod Dev. April 1, 2000; 55 (4): 387-92.

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways., Labbé E, Letamendia A, Attisano L., Proc Natl Acad Sci U S A. July 18, 2000; 97 (15): 8358-63.

Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm., Yang J, Mei W, Otto A, Xiao L, Tao Q, Tao Q, Geng X, Rupp RA, Ding X., Mech Dev. July 1, 2002; 115 (1-2): 79-89.              

The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts., Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V., J Cell Biol. October 14, 2002; 159 (1): 113-22.                  

Lef-1 and Tcf-3 transcription factors mediate tissue-specific Wnt signaling during Xenopus development., Roël G, Hamilton FS, Gent Y, Bain AA, Destrée O, Hoppler S., Curr Biol. November 19, 2002; 12 (22): 1941-5.

Tcf-1 expression during Xenopus development., Roël G, van den Broek O, Spieker N, Peterson-Maduro J, Destrée O., Gene Expr Patterns. May 1, 2003; 3 (2): 123-6.                

VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula., Hilton E, Rex M, Old R., Mech Dev. October 1, 2003; 120 (10): 1127-38.

Integration of multiple signal transducing pathways on Fgf response elements of the Xenopus caudal homologue Xcad3., Haremaki T, Tanaka Y, Hongo I, Yuge M, Okamoto H., Development. October 1, 2003; 130 (20): 4907-17.                  

Regulation of casein kinase I epsilon activity by Wnt signaling., Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM., J Biol Chem. March 26, 2004; 279 (13): 13011-7.            

Cross-regulation of Wnt signaling and cell adhesion., Schambony A, Kunz M, Gradl D., Differentiation. September 1, 2004; 72 (7): 307-18.

Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos., Deroo T, Denayer T, Van Roy F, Vleminckx K, Vleminckx K., J Biol Chem. December 3, 2004; 279 (49): 50670-5.

PR72, a novel regulator of Wnt signaling required for Naked cuticle function., Creyghton MP, Roël G, Eichhorn PJ, Hijmans EM, Maurer I, Destrée O, Bernards R., Genes Dev. February 1, 2005; 19 (3): 376-86.            

Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP., Cui Q, Lim SK, Zhao B, Hoffmann FM., Oncogene. June 2, 2005; 24 (24): 3864-74.

Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability., Ishitani T, Matsumoto K, Chitnis AB, Itoh M., Nat Cell Biol. November 1, 2005; 7 (11): 1106-12.

Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development., Liu F, van den Broek O, Destrée O, Hoppler S., Development. December 1, 2005; 132 (24): 5375-85.          

HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription., Ghogomu SM, van Venrooy S, Ritthaler M, Wedlich D, Gradl D., J Biol Chem. January 20, 2006; 281 (3): 1755-64.            

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)., Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H., J Biol Chem. July 28, 2006; 281 (30): 20749-20760.                    

SALL4 is directly activated by TCF/LEF in the canonical Wnt signaling pathway., Böhm J, Sustmann C, Wilhelm C, Kohlhase J., Biochem Biophys Res Commun. September 29, 2006; 348 (3): 898-907.

Neural induction in Xenopus requires inhibition of Wnt-beta-catenin signaling., Heeg-Truesdell E, LaBonne C., Dev Biol. October 1, 2006; 298 (1): 71-86.                    

Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis., Gao H, Wu B, Giese R, Zhu Z., Cell Res. April 1, 2007; 17 (4): 345-56.

Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis., Wang J, Li S, Chen Y, Chen Y, Ding X., Dev Biol. April 15, 2007; 304 (2): 836-47.                    

Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells., Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM., Mol Cell Biol. November 1, 2007; 27 (22): 7802-15.                

Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription., Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW., Mol Cell Biol. February 1, 2008; 28 (3): 977-87.

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia., Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H., Am J Hum Genet. April 1, 2008; 82 (4): 959-70.

Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus., van Venrooy S, Fichtner D, Kunz M, Wedlich D, Gradl D., BMC Dev Biol. August 7, 2008; 8 77.                                

Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL., Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT., Nat Cell Biol. October 1, 2008; 10 (10): 1208-16.        

Requirement of Wnt/beta-catenin signaling in pronephric kidney development., Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vleminckx K, Vize PD, McCrea PD., Mech Dev. January 1, 2009; 126 (3-4): 142-59.        

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis., Roel G, Gent YY, Peterson-Maduro J, Verbeek FJ, Destree O., Int J Dev Biol. January 1, 2009; 53 (1): 81-9.          

Evolution of non-coding regulatory sequences involved in the developmental process: reflection of differential employment of paralogous genes as highlighted by Sox2 and group B1 Sox genes., Kamachi Y, Iwafuchi M, Okuda Y, Takemoto T, Uchikawa M, Kondoh H., Proc Jpn Acad Ser B Phys Biol Sci. January 1, 2009; 85 (2): 55-68.                  

Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1., Danesin C, Peres JN, Johansson M, Snowden V, Cording A, Papalopulu N, Houart C., Dev Cell. April 1, 2009; 16 (4): 576-87.              

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina., Agathocleous M, Iordanova I, Willardsen MI, Xue XY, Vetter ML, Harris WA, Moore KB., Development. October 1, 2009; 136 (19): 3289-99.                          

Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction., Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Chen YG, Wu W., J Biol Chem. April 2, 2010; 285 (14): 10890-901.                            

beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2., Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS., Dev Cell. August 17, 2010; 19 (2): 220-31.      

Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria., Hernandez L, Roux KJ, Wong ES, Mounkes LC, Mutalif R, Navasankari R, Rai B, Cool S, Jeong JW, Wang H, Lee HS, Kozlov S, Grunert M, Keeble T, Jones CM, Meta MD, Young SG, Daar IO, Burke B, Perantoni AO, Stewart CL., Dev Cell. September 14, 2010; 19 (3): 413-25.  

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