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Summary Expression Phenotypes Gene Literature (71) GO Terms (14) Nucleotides (229) Proteins (47) Interactants (661) Wiki
XB-GENEPAGE-486003

Papers associated with smad7



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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P., Nature. October 9, 1997; 389 (6651): 631-5.

Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase., Chen Y, Bhushan A, Vale W., Proc Natl Acad Sci U S A. November 25, 1997; 94 (24): 12938-43.          

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor., Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A., Genes Dev. January 15, 1998; 12 (2): 186-97.          

Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning., Nakayama T, Snyder MA, Grewal SS, Tsuneizumi K, Tabata T, Christian JL., Development. March 1, 1998; 125 (5): 857-67.                  

Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer., Casellas R, Brivanlou AH., Dev Biol. June 1, 1998; 198 (1): 1-12.                

Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos., Bhushan A, Chen Y, Vale W., Dev Biol. August 15, 1998; 200 (2): 260-8.              

Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors., Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P., J Biol Chem. September 25, 1998; 273 (39): 25364-70.        

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals., Christian JL, Nakayama T., Bioessays. May 1, 1999; 21 (5): 382-90.

Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway., Ramsdell AF, Yost HJ., Development. December 1, 1999; 126 (23): 5195-205.        

Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity., Kawai S, Faucheu C, Gallea S, Spinella-Jaegle S, Atfi A, Baron R, Roman SR., Biochem Biophys Res Commun. May 19, 2000; 271 (3): 682-7.

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB., Nagarajan RP, Chen F, Li W, Vig E, Harrington MA, Nakshatri H, Chen Y., Biochem J. June 15, 2000; 348 Pt 3 591-6.

Expression regulation of hyaluronan synthase in corneal endothelial cells., Usui T, Amano S, Oshika T, Suzuki K, Miyata K, Araie M, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. October 1, 2000; 41 (11): 3261-7.

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation., Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL., Mol Cell. December 1, 2000; 6 (6): 1365-75.

Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7., Nakayama T, Berg LK, Christian JL., Mech Dev. February 1, 2001; 100 (2): 251-62.

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation., Tremblay KD, Dunn NR, Robertson EJ., Development. September 1, 2001; 128 (18): 3609-21.

TGF-beta signalling pathways in early Xenopus development., Hill CS., Curr Opin Genet Dev. October 1, 2001; 11 (5): 533-40.    

Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis., Zohn IE, Brivanlou AH., Dev Biol. November 1, 2001; 239 (1): 118-31.                    

Phosphorylation regulation of the interaction between Smad7 and activin type I receptor., Liu X, Nagarajan RP, Vale W, Chen Y., FEBS Lett. May 22, 2002; 519 (1-3): 93-8.

Cloning and developmental expression of Baf57 in Xenopus laevis., Domingos PM, Obukhanych TV, Altmann CR, Hemmati-Brivanlou A., Mech Dev. August 1, 2002; 116 (1-2): 177-81.    

Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein., Muñoz-Sanjuán I, Bell E, Altmann CR, Vonica A, Brivanlou AH., Development. December 1, 2002; 129 (23): 5529-40.    

Induction and patterning of the telencephalon in Xenopus laevis., Lupo G, Harris WA, Barsacchi G, Vignali R., Development. December 1, 2002; 129 (23): 5421-36.                            

Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads., Sandusky G, Berg DT, Richardson MA, Myers L, Grinnell BW., J Biol Chem. December 20, 2002; 277 (51): 49815-9.

Negative regulation of BMP signaling by the ski oncoprotein., Luo K., J Bone Joint Surg Am. January 1, 2003; 85-A Suppl 3 39-43.

Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor., Bell E, Muñoz-Sanjuán I, Altmann CR, Vonica A, Brivanlou AH., Development. April 1, 2003; 130 (7): 1381-9.    

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads., Murakami G, Watabe T, Takaoka K, Miyazono K, Imamura T., Mol Biol Cell. July 1, 2003; 14 (7): 2809-17.              

Evidence for antagonism of BMP-4 signals by MAP kinase during Xenopus axis determination and neural specification., Sater AK, El-Hodiri HM, Goswami M, Alexander TB, Al-Sheikh O, Etkin LD, Akif Uzman J., Differentiation. September 1, 2003; 71 (7): 434-44.                

Transcriptional regulation of BMP4 synexpression in transgenic Xenopus., Karaulanov E, Knöchel W, Niehrs C., EMBO J. February 25, 2004; 23 (4): 844-56.

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski., Takeda M, Mizuide M, Oka M, Watabe T, Inoue H, Suzuki H, Fujita T, Imamura T, Miyazono K, Miyazawa K., Mol Biol Cell. March 1, 2004; 15 (3): 963-72.                

Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling., Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K., J Biol Chem. July 23, 2004; 279 (30): 31568-74.

Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction., Wawersik S, Evola C, Whitman M., Dev Biol. January 15, 2005; 277 (2): 425-42.                    

The ARID domain protein dril1 is necessary for TGF(beta) signaling in Xenopus embryos., Callery EM, Smith JC, Thomsen GH., Dev Biol. February 15, 2005; 278 (2): 542-59.                              

Smad1 and Smad8 function similarly in mammalian central nervous system development., Hester M, Thompson JC, Mills J, Liu Y, El-Hodiri HM, Weinstein M., Mol Cell Biol. June 1, 2005; 25 (11): 4683-92.

Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1., Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R., J Biol Chem. June 24, 2005; 280 (25): 24227-37.

Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction., Jullien J, Gurdon J., Genes Dev. November 15, 2005; 19 (22): 2682-94.

XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos., Cao Y, Cao Y, Knöchel S, Oswald F, Donow C, Zhao H, Knöchel W., Mech Dev. January 1, 2006; 123 (1): 84-96.      

Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos., Torregroza I, Evans T., Biochem J. January 1, 2006; 393 (Pt 1): 311-20.

Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo., Arnold SJ, Maretto S, Islam A, Bikoff EK, Robertson EJ., Dev Biol. August 1, 2006; 296 (1): 104-18.

Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides., Rana AA, Collart C, Gilchrist MJ, Smith JC., PLoS Genet. November 17, 2006; 2 (11): e193.                                    

Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction., Satow R, Kurisaki A, Chan TC, Hamazaki TS, Asashima M., Dev Cell. December 1, 2006; 11 (6): 763-74.              

Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals., Pestov NB, Ahmad N, Korneenko TV, Zhao H, Radkov R, Schaer D, Roy S, Bibert S, Geering K, Modyanov NN., Proc Natl Acad Sci U S A. July 3, 2007; 104 (27): 11215-20.

Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation., Chang C, Harland RM., Development. November 1, 2007; 134 (21): 3861-72.                

Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct in Xenopus laevis., Bracken CM, Mizeracka K, McLaughlin KA., Dev Dyn. January 1, 2008; 237 (1): 132-44.          

Unexpected activities of Smad7 in Xenopus mesodermal and neural induction., de Almeida I, Rolo A, Batut J, Hill C, Stern CD, Linker C., Mech Dev. January 1, 2008; 125 (5-6): 421-31.              

Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways., Zhao H, Tanegashima K, Ro H, Dawid IB., Development. April 1, 2008; 135 (7): 1283-93.                            

Regulation of activin/nodal signaling by Rap2-directed receptor trafficking., Choi SC, Kim GH, Lee SJ, Park E, Yeo CY, Han JK., Dev Cell. July 1, 2008; 15 (1): 49-61.

Expression cloning of Xenopus zygote arrest 2 (Xzar2) as a novel epidermalization-promoting factor in early embryos of Xenopus laevis., Nakajima Y, Okamoto H, Kubo T, Kubo T., Genes Cells. May 1, 2009; 14 (5): 583-95.                    

The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression., Pittman AM, Naranjo S, Webb E, Broderick P, Lips EH, van Wezel T, Morreau H, Sullivan K, Fielding S, Twiss P, Vijayakrishnan J, Casares F, Qureshi M, Gómez-Skarmeta JL, Houlston RS., Genome Res. June 1, 2009; 19 (6): 987-93.

The role of the visceral mesoderm in the development of the gastrointestinal tract., McLin VA, Henning SJ, Jamrich M., Gastroenterology. June 1, 2009; 136 (7): 2074-91.

Mad is required for wingless signaling in wing development and segment patterning in Drosophila., Eivers E, Fuentealba LC, Sander V, Clemens JC, Hartnett L, De Robertis EM., PLoS One. August 6, 2009; 4 (8): e6543.                    

Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling., Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG., J Biol Chem. October 30, 2009; 284 (44): 30097-104.

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