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Summary Expression Phenotypes Gene Literature (192) GO Terms (6) Nucleotides (126) Proteins (56) Interactants (656) Wiki
XB-GENEPAGE-487965

Papers associated with nkx2-5



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XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development., Tonissen KF, Drysdale TA, Lints TJ, Harvey RP, Krieg PA., Dev Biol. March 1, 1994; 162 (1): 325-8.  

High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci., Himmelbauer H, Harvey RP, Copeland NG, Jenkins NA, Silver LM., Mamm Genome. December 1, 1994; 5 (12): 814-6.

Assignment of cardiac homeobox gene CSX to human chromosome 5q34., Shiojima I, Komuro I, Inazawa J, Nakahori Y, Matsushita I, Abe T, Nagai R, Yazaki Y., Genomics. May 1, 1995; 27 (1): 204-6.

Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5., Chen CY, Schwartz RJ., J Biol Chem. June 30, 1995; 270 (26): 15628-33.

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman., Evans SM, Yan W, Murillo MP, Ponce J, Papalopulu N., Development. November 1, 1995; 121 (11): 3889-99.                

Induction of avian cardiac myogenesis by anterior endoderm., Schultheiss TM, Xydas S, Lassar AB., Development. December 1, 1995; 121 (12): 4203-14.

Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx., Turbay D, Wechsler SB, Blanchard KM, Izumo S., Mol Med. January 1, 1996; 2 (1): 86-96.

Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements., Chen CY, Croissant J, Majesky M, Topouzis S, McQuinn T, Frankovsky MJ, Schwartz RJ., Dev Genet. January 1, 1996; 19 (2): 119-30.

Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development., Buchberger A, Pabst O, Brand T, Seidl K, Arnold HH., Mech Dev. May 1, 1996; 56 (1-2): 151-63.

The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium., Durocher D, Chen CY, Ardati A, Schwartz RJ, Nemer M., Mol Cell Biol. September 1, 1996; 16 (9): 4648-55.

Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia., Cleaver OB, Patterson KD, Krieg PA., Development. November 1, 1996; 122 (11): 3549-56.          

Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription., Chen CY, Schwartz RJ., Mol Cell Biol. November 1, 1996; 16 (11): 6372-84.

Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation., Chen JN, Fishman MC., Development. December 1, 1996; 122 (12): 3809-16.

A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm., Lee KH, Xu Q, Breitbart RE., Dev Biol. December 15, 1996; 180 (2): 722-31.

Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors., Gove C, Walmsley M, Nijjar S, Bertwistle D, Guille M, Partington G, Bomford A, Patient R., EMBO J. January 15, 1997; 16 (2): 355-68.

Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle., Newman CS, Grow MW, Cleaver O, Chia F, Krieg P., Dev Biol. January 15, 1997; 181 (2): 223-33.            

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway., Zou Y, Evans S, Chen J, Kuo HC, Harvey RP, Chien KR., Development. February 1, 1997; 124 (4): 793-804.

Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development., Biben C, Harvey RP., Genes Dev. June 1, 1997; 11 (11): 1357-69.

Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity., Chen CY, Schwartz RJ., Mol Endocrinol. June 1, 1997; 11 (6): 812-22.

Retinoic acid can block differentiation of the myocardium after heart specification., Drysdale TA, Patterson KD, Saha M, Krieg PA., Dev Biol. August 15, 1997; 188 (2): 205-15.          

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors., Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M., EMBO J. September 15, 1997; 16 (18): 5687-96.

Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development., Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE, Izumo S., Dev Genet. January 1, 1998; 22 (3): 239-49.

tinman-related genes expressed during heart development in Xenopus., Newman CS, Krieg PA., Dev Genet. January 1, 1998; 22 (3): 230-8.  

Homeobox genes in cardiovascular development., Patterson KD, Cleaver O, Gerber WV, Grow MW, Newman CS, Krieg PA., Curr Top Dev Biol. January 1, 1998; 40 1-44.

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule., Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, Lah M, Wang CC, Nash A, Hilton D, Ang SL, Mohun T, Harvey RP., Dev Biol. February 15, 1998; 194 (2): 135-51.    

GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression., Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ., Mol Cell Biol. June 1, 1998; 18 (6): 3405-15.

Congenital heart disease caused by mutations in the transcription factor NKX2-5., Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG., Science. July 3, 1998; 281 (5373): 108-11.

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice., Ranganayakulu G, Elliott DA, Harvey RP, Olson EN., Development. August 1, 1998; 125 (16): 3037-48.

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice., Searcy RD, Vincent EB, Liberatore CM, Yutzey KE., Development. November 1, 1998; 125 (22): 4461-70.

Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner., Fu Y, Yan W, Mohun TJ, Evans SM., Development. November 1, 1998; 125 (22): 4439-49.            

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5., Grow MW, Krieg PA., Dev Biol. December 1, 1998; 204 (1): 187-96.      

Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5., Kasahara H, Izumo S., Mol Cell Biol. January 1, 1999; 19 (1): 526-36.

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer., Lien CL, Wu C, Mercer B, Webb R, Richardson JA, Olson EN., Development. January 1, 1999; 126 (1): 75-84.

Seeking a regulatory roadmap for heart morphogenesis., Harvey RP., Semin Cell Dev Biol. February 1, 1999; 10 (1): 99-107.

Vertebrate tinman homologues and cardiac differentiation., Evans SM., Semin Cell Dev Biol. February 1, 1999; 10 (1): 73-83.

Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5., Reecy JM, Li X, Yamada M, DeMayo FJ, Newman CS, Harvey RP, Schwartz RJ., Development. February 1, 1999; 126 (4): 839-49.

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development., Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S., Development. March 1, 1999; 126 (6): 1269-80.

Tbx5 is essential for heart development., Horb ME, Thomsen GH., Development. April 1, 1999; 126 (8): 1739-51.              

Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5., Tanaka M, Wechsler SB, Lee IW, Yamasaki N, Lawitts JA, Izumo S., Development. April 1, 1999; 126 (7): 1439-50.

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site., Amendt BA, Sutherland LB, Russo AF., J Biol Chem. April 23, 1999; 274 (17): 11635-42.

Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5., Rivkees SA, Chen M, Kulkarni J, Browne J, Zhao Z., J Biol Chem. May 14, 1999; 274 (20): 14204-9.

Amphibian embryos as a model system for organ engineering: in vitro induction and rescue of the heart anlage., Grunz H., Int J Dev Biol. July 1, 1999; 43 (4): 361-4.        

Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice., Saadane N, Alpert L, Chalifour LE., Br J Pharmacol. July 1, 1999; 127 (5): 1165-76.

Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4., Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, Hayashi D, Hosoda T, Habara-Ohkubo A, Nakaoka T, Fujita T, Yazaki Y, Komuro I., Mol Cell Biol. October 1, 1999; 19 (10): 7096-105.

Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription., Schwartz RJ, Olson EN., Development. October 1, 1999; 126 (19): 4187-92.

Gata5 is required for the development of the heart and endoderm in zebrafish., Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY., Genes Dev. November 15, 1999; 13 (22): 2983-95.

A role for GATA-4/5/6 in the regulation of Nkx2.5 expression with implications for patterning of the precardiac field., Jiang Y, Drysdale TA, Evans T., Dev Biol. December 1, 1999; 216 (1): 57-71.            

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways., Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD., J Clin Invest. December 1, 1999; 104 (11): 1567-73.

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart., Molkentin JD, Antos C, Mercer B, Taigen T, Miano JM, Olson EN., Dev Biol. January 15, 2000; 217 (2): 301-9.

Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand., Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE., Dev Biol. January 15, 2000; 217 (2): 266-77.  

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