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Summary Expression Phenotypes Gene Literature (72) GO Terms (6) Nucleotides (79) Proteins (40) Interactants (59) Wiki
XB-GENEPAGE-492826

Papers associated with kcna4



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Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels., Yamagishi T, Ishii K, Taira N., Jpn J Pharmacol. April 1, 1993; 61 (4): 371-3.

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?, Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB., Circ Res. June 1, 1993; 72 (6): 1326-36.

Functional role of the NH2-terminal cytoplasmic domain of a mammalian A-type K channel., Tseng-Crank J, Yao JA, Berman MF, Tseng GN., J Gen Physiol. December 1, 1993; 102 (6): 1057-83.

Modulation of an inactivating human cardiac K+ channel by protein kinase C., Murray KT, Fahrig SA, Deal KK, Po SS, Hu NN, Snyders DJ, Tamkun MM, Bennett PB., Circ Res. December 1, 1994; 75 (6): 999-1005.

Molecular mechanisms of K+ channel blockade: 4-aminopyridine interaction with a cloned cardiac transient K+ (Kv1.4) channel., Rasmusson RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Morales MJ, Strauss HC., Adv Exp Med Biol. January 1, 1995; 382 11-22.

A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits., Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC., J Biol Chem. March 17, 1995; 270 (11): 6272-7.

Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes., Rasmusson RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Strauss HC., J Physiol. May 15, 1995; 485 ( Pt 1) 59-71.

Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle., Castellino RC, Morales MJ, Strauss HC, Rasmusson RL., Am J Physiol. July 1, 1995; 269 (1 Pt 2): H385-91.

Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4., Yamagishi T, Ishii K, Taira N., Eur J Pharmacol. August 4, 1995; 281 (2): 151-9.

Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product., McCormack K, McCormack T, Tanouye M, Rudy B, Stühmer W., FEBS Lett. August 14, 1995; 370 (1-2): 32-6.

Susceptibility of cloned K+ channels to reactive oxygen species., Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E., Proc Natl Acad Sci U S A. December 5, 1995; 92 (25): 11796-800.

C-type inactivation controls recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes., Rasmusson RL, Morales MJ, Castellino RC, Zhang Y, Campbell DL, Strauss HC., J Physiol. December 15, 1995; 489 ( Pt 3) 709-21.

Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit., Heinemann SH, Rettig J, Wunder F, Pongs O., FEBS Lett. December 27, 1995; 377 (3): 383-9.

N-type inactivation in the mammalian Shaker K+ channel Kv1.4., Lee TE, Philipson LH, Nelson DJ., J Membr Biol. June 1, 1996; 151 (3): 225-35.

Functional characterization of Kv channel beta-subunits from rat brain., Heinemann SH, Rettig J, Graack HR, Pongs O., J Physiol. June 15, 1996; 493 ( Pt 3) 625-33.

Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene., Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG., J Biol Chem. June 28, 1996; 271 (26): 15629-34.

Quinidine enhances and suppresses Kv1.2 from outside and inside the cell, respectively., Tseng GN, Zhu B, Ling S, Yao JA., J Pharmacol Exp Ther. November 1, 1996; 279 (2): 844-55.

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes., Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE., Br J Pharmacol. March 1, 1997; 120 (5): 968-74.

Channel-specific effects of n-alkyl sulphate anions on three shaker-related potassium channels expressed in Xenopus oocytes., Elliott AA, Elliott JR., Pflugers Arch. May 1, 1997; 434 (1): 132-6.

A mammalian transient type K+ channel, rat Kv1.4, has two potential domains that could produce rapid inactivation., Kondoh S, Ishii K, Nakamura Y, Taira N., J Biol Chem. August 1, 1997; 272 (31): 19333-8.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum., Folco E, Mathur R, Mori Y, Buckett P, Koren G., J Biol Chem. October 17, 1997; 272 (42): 26505-10.

Modification of rat brain Kv1.4 channel gating by association with accessory Kvbeta1.1 and beta2.1 subunits., McIntosh P, Southan AP, Akhtar S, Sidera C, Ushkaryov Y, Dolly JO, Robertson B., Pflugers Arch. December 1, 1997; 435 (1): 43-54.

Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes., Chen H, Kubo Y, Hoshi T, Heinemann SH., FEBS Lett. February 6, 1998; 422 (3): 307-10.

Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes., Hopkins WF., J Pharmacol Exp Ther. June 1, 1998; 285 (3): 1051-60.

Influence of outer pore residue K533 on the inhibition of Kv1.4 potassium channels by n-alkyl sulphate anions., MacDonald S, Elliott AA, Harrold JA, Elliott JR., Pflugers Arch. July 1, 1998; 436 (4): 623-6.

Differential effects of S6 mutations on binding of quinidine and 4-aminopyridine to rat isoform of Kv1.4: common site but different factors in determining blockers' binding affinity., Zhang H, Zhu B, Yao JA, Tseng GN., J Pharmacol Exp Ther. October 1, 1998; 287 (1): 332-43.

Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4., Accili EA, Kuryshev YA, Wible BA, Brown AM., J Physiol. October 15, 1998; 512 ( Pt 2) 325-36.

Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes., Wickenden AD, Tsushima RG, Losito VA, Kaprielian R, Backx PH., Cell Physiol Biochem. January 1, 1999; 9 (1): 11-28.

Transplanting the N-terminus from Kv1.4 to Kv1.1 generates an inwardly rectifying K+ channel., Chanda B, Tiwari JK, Varshney A, Mathew MK., Neuroreport. February 5, 1999; 10 (2): 237-41.

Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore., Jerng HH, Shahidullah M, Covarrubias M., J Gen Physiol. May 1, 1999; 113 (5): 641-60.                        

A functional spliced-variant of beta 2 subunit of Kv1 channels in C6 glioma cells and reactive astrocytes from rat lesioned cerebellum., Akhtar S, McIntosh P, Bryan-Sisneros A, Barratt L, Robertson B, Dolly JO., Biochemistry. December 21, 1999; 38 (51): 16984-92.

Changes in the inactivation of rat Kv1.4 K(+) channels induced by varying the number of inactivation particles., Hashimoto Y, Nunoki K, Kudo H, Ishii K, Taira N, Yanagisawa T., J Biol Chem. March 31, 2000; 275 (13): 9358-62.

Inhibition of the K+ channel kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery from N-type inactivation., Claydon TW, Boyett MR, Sivaprasadarao A, Ishii K, Owen JM, O'Beirne HA, Leach R, Komukai K, Orchard CH., J Physiol. July 15, 2000; 526 Pt 2 253-64.

Mutations in the Kv beta 2 binding site for NADPH and their effects on Kv1.4., Peri R, Wible BA, Brown AM., J Biol Chem. January 5, 2001; 276 (1): 738-41.

Cloning and expression of three K+ channel cDNAs from Xenopus muscle., Fry M, Paterno G, Moody-Corbett F., Brain Res Mol Brain Res. June 20, 2001; 90 (2): 135-48.          

A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents., Nakamura TY, Pountney DJ, Ozaita A, Nandi S, Ueda S, Rudy B, Coetzee WA., Proc Natl Acad Sci U S A. October 23, 2001; 98 (22): 12808-13.

Cumulative inactivation and the pore domain in the Kv1 channels., Shimizu Y, Kubo T, Furukawa Y., Pflugers Arch. March 1, 2002; 443 (5-6): 720-30.

Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation., Padanilam BJ, Lu T, Hoshi T, Padanilam BA, Shibata EF, Lee HC., Mol Pharmacol. July 1, 2002; 62 (1): 127-34.

Two pore residues mediate acidosis-induced enhancement of C-type inactivation of the Kv1.4 K(+) channel., Claydon TW, Boyett MR, Sivaprasadarao A, Orchard CH., Am J Physiol Cell Physiol. October 1, 2002; 283 (4): C1114-21.

Expression of voltage-dependent potassium channels in the developing visual system of Xenopus laevis., Pollock NS, Ferguson SC, McFarlane S., J Comp Neurol. October 28, 2002; 452 (4): 381-91.                

Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication., Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL., Am J Physiol Heart Circ Physiol. January 1, 2003; 284 (1): H71-80.

Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect., Wang S, Morales MJ, Qu YJ, Bett GC, Strauss HC, Rasmusson RL., J Physiol. January 15, 2003; 546 (Pt 2): 387-401.

C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes., Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL., J Physiol. June 15, 2003; 549 (Pt 3): 683-95.

Differential inhibition of transient outward currents of Kv1.4 and Kv4.3 by endothelin., Hagiwara K, Nunoki K, Ishii K, Abe T, Yanagisawa T., Biochem Biophys Res Commun. October 17, 2003; 310 (2): 634-40.

Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore., Bett GC, Rasmusson RL., J Physiol. April 1, 2004; 556 (Pt 1): 109-20.

Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue., Zhang ZH, Rhodes KJ, Childers WE, Argentieri TM, Wang Q., J Biol Chem. July 9, 2004; 279 (28): 29226-30.

K+ activation of kir3.1/kir3.4 and kv1.4 K+ channels is regulated by extracellular charges., Claydon TW, Makary SY, Dibb KM, Boyett MR., Biophys J. October 1, 2004; 87 (4): 2407-18.

N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix., Sankaranarayanan K, Varshney A, Mathew MK., Mol Membr Biol. January 1, 2005; 22 (5): 389-400.

A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels., Herrera D, Mamarbachi A, Simoes M, Parent L, Sauvé R, Wang Z, Nattel S., Mol Pharmacol. August 1, 2005; 68 (2): 305-16.

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