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Summary Expression Gene Literature (53) GO Terms (7) Nucleotides (52) Proteins (29) Interactants (151) Wiki
XB-GENEPAGE-493229

Papers associated with gja8

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Modeling ocular lens disease in Xenopus., Viet J, Reboutier D, Hardy S, Lachke SA, Paillard L, Gautier-Courteille C., Dev Dyn. January 1, 2020; 249 (5): 610-621.          


Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins., Pinto BI, García IE, Pupo A, Retamal MA, Martínez AD, Latorre R, González C., J Biol Chem. January 1, 2016; 291 (30): 15740-52.


Differential regulation of Connexin50 and Connexin46 by PI3K signaling., Martinez JM, Wang HZ, Lin RZ, Brink PR, White TW., FEBS Lett. May 22, 2015; 589 (12): 1340-5.


The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating., Tong JJ, Minogue PJ, Kobeszko M, Beyer EC, Berthoud VM, Ebihara L., J Membr Biol. February 1, 2015; 248 (1): 145-55.                


Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel Currents., Oh S., Korean J Physiol Pharmacol. January 1, 2015; 19 (1): 73-9.        


Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus., Slavi N, Rubinos C, Li L, Sellitto C, White TW, Mathias R, Srinivas M., J Biol Chem. November 21, 2014; 289 (47): 32694-702.


Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion., Kumari SS, Gandhi J, Mustehsan MH, Eren S, Varadaraj K., Exp Eye Res. November 1, 2013; 116 371-85.                  


Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46., Tong JJ, Sohn BC, Lam A, Walters DE, Vertel BM, Ebihara L., Am J Physiol Cell Physiol. May 1, 2013; 304 (9): C823-32.


Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances., Kwon T, Tang Q, Bargiello TA., J Gen Physiol. February 1, 2013; 141 (2): 243-59.                  


Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels., Schlingmann B, Schadzek P, Busko S, Heisterkamp A, Ngezahayo A., J Bioenerg Biomembr. October 1, 2012; 44 (5): 607-14.


Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium., Rubinos C, Sánchez HA, Verselis VK, Srinivas M., J Gen Physiol. January 1, 2012; 139 (1): 69-82.                    


Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2., Xia CH, Chang B, Derosa AM, Cheng C, White TW, Gong X., PLoS One. January 1, 2012; 7 (12): e52894.          


Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50., Tong JJ, Minogue PJ, Guo W, Chen TL, Beyer EC, Berthoud VM, Ebihara L., Am J Physiol Cell Physiol. May 1, 2011; 300 (5): C1055-64.


Properties of connexin 46 hemichannels in dissociated lens fiber cells., Ebihara L, Tong JJ, Vertel B, White TW, Chen TL., Invest Ophthalmol Vis Sci. February 1, 2011; 52 (2): 882-9.


Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other., Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE., J Biol Chem. August 6, 2010; 285 (32): 24420-31.                    


Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome., Sánchez HA, Mese G, Srinivas M, White TW, Verselis VK., J Gen Physiol. July 1, 2010; 136 (1): 47-62.                  


A mutant connexin50 with enhanced hemichannel function leads to cell death., Minogue PJ, Tong JJ, Arora A, Russell-Eggitt I, Hunt DM, Moore AT, Ebihara L, Beyer EC, Berthoud VM., Invest Ophthalmol Vis Sci. December 1, 2009; 50 (12): 5837-45.


The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation., Graw J, Schmidt W, Minogue PJ, Rodriguez J, Tong JJ, Klopp N, Illig T, Ebihara L, Berthoud VM, Beyer EC., Mol Vis. September 14, 2009; 15 1881-5.      


Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis., Shakespeare TI, Sellitto C, Li L, Rubinos C, Gong X, Srinivas M, White TW., Mol Biol Cell. May 1, 2009; 20 (10): 2582-92.


The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium., DeRosa AM, Meşe G, Li L, Sellitto C, Brink PR, Gong X, White TW., Exp Cell Res. April 1, 2009; 315 (6): 1063-75.


Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain., Verselis VK, Trelles MP, Rubinos C, Bargiello TA, Srinivas M., J Biol Chem. February 13, 2009; 284 (7): 4484-93.


Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner., Banks EA, Toloue MM, Shi Q, Zhou ZJ, Liu J, Nicholson BJ, Jiang JX., J Cell Sci. February 1, 2009; 122 (Pt 3): 378-88.


Site-directed mutagenesis reveals putative regions of protein interaction within the transmembrane domains of connexins., Toloue MM, Woolwine Y, Karcz JA, Kasperek EM, Nicholson BJ, Skerrett IM., Cell Commun Adhes. May 1, 2008; 15 (1): 95-105.


A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts., Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT., J Med Genet. March 1, 2008; 45 (3): 155-60.


The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins., DeRosa AM, Xia CH, Gong X, White TW., J Cell Sci. December 1, 2007; 120 (Pt 23): 4107-16.


Transgenic overexpression of connexin50 induces cataracts., Chung J, Berthoud VM, Novak L, Zoltoski R, Heilbrunn B, Minogue PJ, Liu X, Ebihara L, Kuszak J, Beyer EC., Exp Eye Res. March 1, 2007; 84 (3): 513-28.


Functional characterization of a naturally occurring Cx50 truncation., DeRosa AM, Mui R, Srinivas M, White TW., Invest Ophthalmol Vis Sci. October 1, 2006; 47 (10): 4474-81.


Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel., Beahm DL, Oshima A, Gaietta GM, Hand GM, Smock AE, Zucker SN, Toloue MM, Chandrasekhar A, Nicholson BJ, Sosinsky GE., J Biol Chem. March 24, 2006; 281 (12): 7994-8009.


A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract., Arora A, Minogue PJ, Liu X, Reddy MA, Ainsworth JR, Bhattacharya SS, Webster AR, Hunt DM, Ebihara L, Moore AT, Beyer EC, Berthoud VM., J Med Genet. January 1, 2006; 43 (1): e2.


Regulation of connexin hemichannels by monovalent cations., Srinivas M, Calderon DP, Kronengold J, Verselis VK., J Gen Physiol. January 1, 2006; 127 (1): 67-75.          


Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes., Kotsias BA, Salim M, Peracchia LL, Peracchia C., J Membr Biol. January 1, 2006; 214 (1): 1-8.


Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50., Peracchia C, Peracchia LL., Am J Physiol Cell Physiol. June 1, 2005; 288 (6): C1381-9.


Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels., Srinivas M, Kronengold J, Bukauskas FF, Bargiello TA, Verselis VK., Biophys J. March 1, 2005; 88 (3): 1725-39.


Connexins are mechanosensitive., Bao L, Sachs F, Dahl G., Am J Physiol Cell Physiol. November 1, 2004; 287 (5): C1389-95.


Exchange of gating properties between rat cx46 and chicken cx45.6., Tong JJ, Liu X, Dong L, Ebihara L., Biophys J. October 1, 2004; 87 (4): 2397-406.


CO(2) sensitivity of voltage gating and gating polarity of gapjunction channels--connexin40 and its COOH-terminus-truncated mutant., Peracchia C, Chen JT, Peracchia LL., J Membr Biol. July 15, 2004; 200 (2): 105-13.


Hemichannel and junctional properties of connexin 50., Beahm DL, Hall JE., Biophys J. April 1, 2002; 82 (4): 2016-31.


Inhibition of gap junction hemichannels by chloride channel blockers., Eskandari S, Zampighi GA, Leung DW, Wright EM, Loo DD., J Membr Biol. January 15, 2002; 185 (2): 93-102.


Characterization of a mouse Cx50 mutation associated with the No2 mouse cataract., Xu X, Ebihara L., Invest Ophthalmol Vis Sci. July 1, 1999; 40 (8): 1844-50.


Hetero-domain interactions as a mechanism for the regulation of connexin channels., Stergiopoulos K, Alvarado JL, Mastroianni M, Ek-Vitorin JF, Taffet SM, Delmar M., Circ Res. May 28, 1999; 84 (10): 1144-55.


Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes., Zampighi GA, Loo DD, Kreman M, Eskandari S, Wright EM., J Gen Physiol. April 1, 1999; 113 (4): 507-24.                          


Molecular mechanism underlying a Cx50-linked congenital cataract., Pal JD, Berthoud VM, Beyer EC, Mackay D, Shiels A, Ebihara L., Am J Physiol. January 1, 1999; 276 (6): C1443-6.


Biological functions of connexin genes revealed by human genetic defects, dominant negative approaches and targeted deletions in the mouse., Willecke K, Kirchhoff S, Plum A, Temme A, Thönnissen E, Ott T., Novartis Found Symp. January 1, 1999; 219 76-88; discussion 88-96.


Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior., Ebihara L, Xu X, Oberti C, Beyer EC, Berthoud VM., Biophys J. January 1, 1999; 76 (1 Pt 1): 198-206.


Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy., Eskandari S, Wright EM, Kreman M, Starace DM, Zampighi GA., Proc Natl Acad Sci U S A. September 15, 1998; 95 (19): 11235-40.


Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage., Lin JS, Eckert R, Kistler J, Donaldson P., Eur J Cell Biol. August 1, 1998; 76 (4): 246-50.


Connexin32 mutations associated with X-linked Charcot-Marie-Tooth disease show two distinct behaviors: loss of function and altered gating properties., Ressot C, Gomès D, Dautigny A, Pham-Dinh D, Bruzzone R., J Neurosci. June 1, 1998; 18 (11): 4063-75.


Changes in lens connexin expression lead to increased gap junctional voltage dependence and conductance., Donaldson PJ, Dong Y, Roos M, Green C, Goodenough DA, Kistler J., Am J Physiol. September 1, 1995; 269 (3 Pt 1): C590-600.


Functional analysis of selective interactions among rodent connexins., White TW, Paul DL, Goodenough DA, Bruzzone R., Mol Biol Cell. April 1, 1995; 6 (4): 459-70.


Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression., Gupta VK, Berthoud VM, Atal N, Jarillo JA, Barrio LC, Beyer EC., Invest Ophthalmol Vis Sci. September 1, 1994; 35 (10): 3747-58.

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