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Summary Expression Phenotypes Gene Literature (198) GO Terms (2) Nucleotides (430) Proteins (122) Interactants (198) Wiki
XB-GENEPAGE-494199

Papers associated with grin1



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Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery., O'Connor EC, Kambara K, Bertrand D., Expert Opin Drug Discov. February 1, 2024; 19 (2): 173-187.      

Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy., Xu Y, Song R, Chen W, Strong K, Shrey D, Gedela S, Traynelis SF, Zhang G, Yuan H., Ann Clin Transl Neurol. July 1, 2021; 8 (7): 1480-1494.            

Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders., Tang W, Liu D, Traynelis SF, Yuan H., Neuropharmacology. October 15, 2020; 177 108247.

Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology., Chen H, Vandorpe DH, Xie X, Alper SL, Zeidel ML, Yu W., Nat Commun. August 28, 2020; 11 (1): 4328.                    

Postsynaptic and Presynaptic NMDARs Have Distinct Roles in Visual Circuit Development., Kesner P, Schohl A, Warren EC, Ma F, Ruthazer ES., Cell Rep. July 28, 2020; 32 (4): 107955.                                            

De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases., Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, Myers SJ, Swanger SA, Wollmuth LP, Petrovski S, Traynelis SF, Yuan H., Hum Mutat. December 1, 2019; 40 (12): 2393-2413.

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups., Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF., Elife. May 24, 2018; 7                                                                         

Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants., Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A., Channels (Austin). January 1, 2018; 12 (1): 299-310.            

All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class., Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M., Mol Psychiatry. December 1, 2017; 22 (12): 1776-1784.

GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors., Mullier B, Wolff C, Sands ZA, Ghisdal P, Muglia P, Kaminski RM, André VM., Neuropharmacology. September 1, 2017; 123 322-331.

Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy., Lemke JR, Geider K, Helbig KL, Heyne HO, Schütz H, Hentschel J, Courage C, Depienne C, Nava C, Heron D, Møller RS, Hjalgrim H, Lal D, Neubauer BA, Nürnberg P, Thiele H, Kurlemann G, Arnold GL, Bhambhani V, Bartholdi D, Pedurupillay CR, Misceo D, Frengen E, Strømme P, Dlugos DJ, Doherty ES, Bijlsma EK, Ruivenkamp CA, Hoffer MJ, Goldstein A, Rajan DS, Narayanan V, Ramsey K, Belnap N, Schrauwen I, Richholt R, Koeleman BP, Sá J, Mendonça C, de Kovel CG, Weckhuysen S, Hardies K, De Jonghe P, De Meirleir L, Milh M, Badens C, Lebrun M, Busa T, Francannet C, Piton A, Riesch E, Biskup S, Vogt H, Dorn T, Helbig I, Michaud JL, Laube B, Syrbe S., Neurology. June 7, 2016; 86 (23): 2171-8.  

The nitrate transporter MtNPF6.8 (MtNRT1.3) transports abscisic acid and mediates nitrate regulation of primary root growth in Medicago truncatula., Pellizzaro A, Clochard T, Cukier C, Bourdin C, Juchaux M, Montrichard F, Thany S, Raymond V, Planchet E, Limami AM, Morère-Le Paven MC., Plant Physiol. December 1, 2014; 166 (4): 2152-65.

GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy., Lemke JR, Hendrickx R, Geider K, Laube B, Schwake M, Harvey RJ, James VM, Pepler A, Steiner I, Hörtnagel K, Neidhardt J, Ruf S, Wolff M, Bartholdi D, Caraballo R, Platzer K, Suls A, De Jonghe P, Biskup S, Weckhuysen S., Ann Neurol. January 1, 2014; 75 (1): 147-54.      

Efficient high-throughput sequencing of a laser microdissected chromosome arm., Seifertova E, Zimmerman LB, Gilchrist MJ, Macha J, Kubickova S, Cernohorska H, Zarsky V, Owens ND, Sesay AK, Tlapakova T, Krylov V., BMC Genomics. May 28, 2013; 14 357.        

Lin28 proteins are required for germ layer specification in Xenopus., Faas L, Warrander FC, Maguire R, Ramsbottom SA, Quinn D, Genever P, Isaacs HV., Development. March 1, 2013; 140 (5): 976-86.                      

Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and neuroprotective effects in in vitro and in vivo., Masuko T, Suzuki T, Miyake M, Kusama-Eguchi K, Kizawa Y, Tomono K, Kashiwagi K, Igarashi K, Kusama T., Neurosci Lett. January 11, 2012; 506 (2): 251-5.

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons., Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH., J Neurochem. November 1, 2011; 119 (3): 486-96.

Histone deacetylase activity is necessary for left-right patterning during vertebrate development., Carneiro K, Donnet C, Rejtar T, Karger BL, Barisone GA, Díaz E, Kortagere S, Lemire JM, Levin M., BMC Dev Biol. May 20, 2011; 11 29.              

Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block., Cavara NA, Orth A, Hicking G, Seebohm G, Hollmann M., BMC Neurosci. October 19, 2010; 11 133.          

The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit., Zhang Y, Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li J, Zhou Z, Wang KW, Wang Y., J Neurosci. June 2, 2010; 30 (22): 7575-86.

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists., Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, Murphy TJ, Snyder JP, Bräuner-Osborne H, Traynelis SF., J Pharmacol Exp Ther. June 1, 2010; 333 (3): 650-62.

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues., Lolli ML, Giordano C, Pickering DS, Rolando B, Hansen KB, Foti A, Contreras-Sanz A, Amir A, Fruttero R, Gasco A, Nielsen B, Johansen TN., J Med Chem. May 27, 2010; 53 (10): 4110-8.

Regulation of AMPA receptor trafficking by O-glycosylation., Kanno T, Yaguchi T, Nagata T, Mukasa T, Nishizaki T., Neurochem Res. May 1, 2010; 35 (5): 782-8.

Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors., Dravid SM, Burger PB, Prakash A, Geballe MT, Yadav R, Le P, Vellano K, Snyder JP, Traynelis SF., J Neurosci. February 17, 2010; 30 (7): 2741-54.

Regulation of radial glial motility by visual experience., Tremblay M, Fugère V, Tsui J, Schohl A, Tavakoli A, Travençolo BA, Costa Lda F, Ruthazer ES., J Neurosci. November 11, 2009; 29 (45): 14066-76.                

Neuroprotection by tosyl-polyamine derivatives through the inhibition of ionotropic glutamate receptors., Masuko T, Namiki R, Nemoto Y, Miyake M, Kizawa Y, Suzuki T, Kashiwagi K, Igarashi K, Kusama T., J Pharmacol Exp Ther. November 1, 2009; 331 (2): 522-30.

Molecular and functional characterization of Xenopus laevis N-methyl-d-aspartate receptors., Schmidt C, Hollmann M., Mol Cell Neurosci. October 1, 2009; 42 (2): 116-27.

Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles., Ewald RC, Cline HT., Front Mol Neurosci. September 11, 2009; 2 4.          

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors., Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF., J Biol Chem. May 8, 2009; 284 (19): 12862-73.

Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors., Cavara NA, Orth A, Hollmann M., BMC Neurosci. April 6, 2009; 10 32.      

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes., Puddifoot CA, Chen PE, Schoepfer R, Wyllie DJ., Br J Pharmacol. February 1, 2009; 156 (3): 509-18.

Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors., Sivaprakasam M, Hansen KB, David O, Nielsen B, Traynelis SF, Clausen RP, Couty F, Bunch L., ChemMedChem. January 1, 2009; 4 (1): 110-7.

Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor., Han X, Tomitori H, Mizuno S, Higashi K, Füll C, Fukiwake T, Terui Y, Leewanich P, Nishimura K, Toida T, Williams K, Kashiwagi K, Igarashi K., J Neurochem. December 1, 2008; 107 (6): 1566-77.

Differential effect of high pressure on NMDA receptor currents in Xenopus laevis oocytes., Mor A, Levy S, Hollmann M, Gerossman Y., Diving Hyperb Med. December 1, 2008; 38 (4): 194-6.

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function., Samson AL, Nevin ST, Croucher D, Niego B, Daniel PB, Weiss TW, Moreno E, Monard D, Lawrence DA, Medcalf RL., J Neurochem. November 1, 2008; 107 (4): 1091-101.

Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies., Ng FM, Geballe MT, Snyder JP, Traynelis SF, Low CM., Mol Brain. October 29, 2008; 1 16.            

Different structural requirements for functional ion pore transplantation suggest different gating mechanisms of NMDA and kainate receptors., Villmann C, Hoffmann J, Werner M, Kott S, Strutz-Seebohm N, Nilsson T, Hollmann M., J Neurochem. October 1, 2008; 107 (2): 453-65.

Rules of engagement for NMDA receptor subunits., Ulbrich MH, Isacoff EY., Proc Natl Acad Sci U S A. September 16, 2008; 105 (37): 14163-8.

Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia., Yang L, Sonner JM., Anesth Analg. September 1, 2008; 107 (3): 868-74.

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist., Madry C, Betz H, Geiger JR, Laube B., Proc Natl Acad Sci U S A. August 26, 2008; 105 (34): 12563-8.

The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor., Blanke ML, VanDongen AM., Mol Pharmacol. August 1, 2008; 74 (2): 454-65.

Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds., Blanke ML, VanDongen AM., J Biol Chem. August 1, 2008; 283 (31): 21519-29.

Differential effects of linear and cyclic polyamines on NMDA receptor activities., Masuko T, Miyake M, Kusama-Eguchi K, Koike T, Kimura E, Kizawa Y, Kashiwagi K, Igarashi K, Kusama T., Neurochem Int. July 1, 2008; 53 (1-2): 38-44.

Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor., Chang HR, Kuo CC., J Med Chem. March 27, 2008; 51 (6): 1534-45.

Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit., Schmidt C, Hollmann M., J Mol Biol. February 22, 2008; 376 (3): 658-70.

The activation gate and gating mechanism of the NMDA receptor., Chang HR, Kuo CC., J Neurosci. February 13, 2008; 28 (7): 1546-56.

Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition., Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J, Paoletti P., Neuron. January 10, 2008; 57 (1): 80-93.

Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly., Schüler T, Mesic I, Madry C, Bartholomäus I, Laube B., J Biol Chem. January 4, 2008; 283 (1): 37-46.

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes., Wrighton DC, Baker EJ, Chen PE, Wyllie DJ., J Physiol. January 1, 2008; 586 (1): 211-25.

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes., Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ., J Physiol. January 1, 2008; 586 (1): 227-45.

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