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Summary Expression Phenotypes Gene Literature (45) GO Terms (3) Nucleotides (67) Proteins (36) Interactants (93) Wiki
XB-GENEPAGE-5824518

Papers associated with stk39



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Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression., Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castañeda-Bueno M, Alessi DR, Gamba G., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.                    

Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT., Vachel L, Shcheynikov N, Yamazaki O, Fremder M, Ohana E, Son A, Shin DM, Yamazaki-Nakazawa A, Yang CR, Knepper MA, Muallem S., Sci Signal. October 30, 2018; 11 (554):


Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC., Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama A, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D, Gamba G., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway., Bazúa-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, Murillo-de-Ozores AR, González-Mariscal L, Ellison DH, Riccardi D, Bobadilla NA, Gamba G., J Am Soc Nephrol. July 1, 2018; 29 (7): 1838-1848.

Phosphoregulation of K+ -Cl- cotransporters during cell swelling: Novel insights., Frenette-Cotton R, Marcoux AA, Garneau AP, Noel M, Isenring P., J Cell Physiol. January 1, 2018; 233 (1): 396-408.

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters., Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G., Am J Physiol Cell Physiol. July 1, 2016; 311 (1): C54-66.

OSR1 and SPAK Sensitivity of Large-Conductance Ca2+ Activated K+ Channel., Elvira B, Singh Y, Warsi J, Munoz C, Lang F., Cell Physiol Biochem. January 1, 2016; 38 (4): 1652-62.

Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1., Abousaab A, Warsi J, Elvira B, Alesutan I, Hoseinzadeh Z, Lang F., J Membr Biol. December 1, 2015; 248 (6): 1107-19.

SPAK and OSR1 sensitivity of voltage-gated K+ channel Kv1.5., Elvira B, Warsi J, Munoz C, Lang F., J Membr Biol. February 1, 2015; 248 (1): 59-66.

SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3., Borrás J, Salker MS, Elvira B, Warsi J, Fezai M, Hoseinzadeh Z, Lang F., Nephron. January 1, 2015; 130 (3): 221-8.

SPAK Sensitive Regulation of the Epithelial Na Channel ENaC., Ahmed M, Salker MS, Elvira B, Umbach AT, Fakhri H, Saeed AM, Shumilina E, Hosseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2015; 40 (4): 335-43.

Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1., Fezai M, Elvira B, Warsi J, Ben-Attia M, Hosseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2015; 40 (6): 555-64.

SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels., Elvira B, Warsi J, Fezai M, Munoz C, Lang F., Cell Physiol Biochem. January 1, 2015; 37 (5): 2032-42.

SPAK and OSR1 Sensitive Kir2.1 K+ Channels., Fezai M, Ahmed M, Hosseinzadeh Z, Elvira B, Lang F., Neurosignals. January 1, 2015; 23 (1): 20-33.

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4., Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J., Hypertension. November 1, 2014; 64 (5): 1047-53.

SPAK-sensitive regulation of glucose transporter SGLT1., Elvira B, Blecua M, Luo D, Yang W, Shumilina E, Munoz C, Lang F., J Membr Biol. November 1, 2014; 247 (11): 1191-7.

Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage., Markadieu N, Rios K, Spiller BW, McDonald WH, Welling PA, Delpire E., J Biol Chem. October 17, 2014; 289 (42): 29273-84.

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter., Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G., Am J Physiol Renal Physiol. August 1, 2014; 307 (3): F275-86.

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension., Picard N, Trompf K, Yang CL, Miller RL, Carrel M, Loffing-Cueni D, Fenton RA, Ellison DH, Loffing J., J Am Soc Nephrol. March 1, 2014; 25 (3): 511-22.

SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1., Elvira B, Munoz C, Borras J, Chen H, Warsi J, Ajay SS, Shumilina E, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 353-60.

Regulation of ClC-2 activity by SPAK and OSR1., Warsi J, Hosseinzadeh Z, Elvira B, Bissinger R, Shumilina E, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 378-87.

SPAK dependent regulation of peptide transporters PEPT1 and PEPT2., Warsi J, Dong L, Elvira B, Salker MS, Shumilina E, Hosseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 388-98.

Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1., Fezai M, Elvira B, Borras J, Ben-Attia M, Hoseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (6): 546-54.

Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2., Park HJ, Curry JN, McCormick JA., Am J Physiol Renal Physiol. December 15, 2013; 305 (12): F1687-96.

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling., Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G., J Biol Chem. November 1, 2013; 288 (44): 31468-76.            

WNK4 is an essential effector of anterior formation in FGF signaling., Shimizu M, Goto T, Sato A, Shibuya H., Genes Cells. June 1, 2013; 18 (6): 442-9.        

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers., Ponce-Coria J, Gagnon KB, Delpire E., Am J Physiol Cell Physiol. December 1, 2012; 303 (11): C1198-205.

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process., Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G., Proc Natl Acad Sci U S A. May 15, 2012; 109 (20): 7929-34.

Ion and solute transport by Prestin in Drosophila and Anopheles., Hirata T, Czapar A, Brin L, Haritonova A, Bondeson DP, Linser P, Cabrero P, Thompson J, Dow JA, Romero MF., J Insect Physiol. April 1, 2012; 58 (4): 563-9.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S., Biol Open. February 15, 2012; 1 (2): 120-7.              

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family., Pacheco-Alvarez D, Vázquez N, Castañeda-Bueno M, de-Los-Heros P, Cortes-González C, Moreno E, Meade P, Bobadilla NA, Gamba G., Cell Physiol Biochem. January 1, 2012; 29 (1-2): 291-302.

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Molecular determinants of hyperosmotically activated NKCC1-mediated K+/K+ exchange., Gagnon KB, Delpire E., J Physiol. September 15, 2010; 588 (Pt 18): 3385-96.

A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190., Glover M, Sweeny C, Davis B, O'Shaughnessy KM., Open Med Chem J. September 3, 2010; 4 57-61.        

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity., Gagnon KB, Delpire E., Am J Physiol Cell Physiol. September 1, 2010; 299 (3): C614-20.

Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1., Gagnon KB, Delpire E., J Biol Chem. May 7, 2010; 285 (19): 14115-21.

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M, Zuber AM, O'Shaughnessy KM., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway., San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G., Proc Natl Acad Sci U S A. March 17, 2009; 106 (11): 4384-9.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases., Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. June 17, 2008; 105 (24): 8458-63.

Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation., Gagnon KB, England R, Diehl L, Delpire E., Am J Physiol Cell Physiol. May 1, 2007; 292 (5): C1809-15.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter., Gagnon KB, England R, Delpire E., Cell Physiol Biochem. January 1, 2007; 20 (1-4): 131-42.

Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter., Gagnon KB, England R, Delpire E., Mol Cell Biol. January 1, 2006; 26 (2): 689-98.

Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4., Gagnon KB, England R, Delpire E., Am J Physiol Cell Physiol. January 1, 2006; 290 (1): C134-42.

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase., Piechotta K, Garbarini N, England R, Delpire E., J Biol Chem. December 26, 2003; 278 (52): 52848-56.

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