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Summary Expression Phenotypes Gene Literature (83) GO Terms (3) Nucleotides (101) Proteins (44) Interactants (134) Wiki
XB--5842249

Papers associated with slc22a6



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Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney., Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK., J Biol Chem. March 7, 1997; 272 (10): 6471-8.

Expression cloning and characterization of a novel multispecific organic anion transporter., Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H., J Biol Chem. July 25, 1997; 272 (30): 18526-9.

Expression cloning and characterization of a renal organic anion transporter from winter flounder., Wolff NA, Werner A, Burkhardt S, Burckhardt G., FEBS Lett. November 17, 1997; 417 (3): 287-91.

Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney., Sweet DH, Wolff NA, Pritchard JB., J Biol Chem. November 28, 1997; 272 (48): 30088-95.

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver., Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H., FEBS Lett. June 12, 1998; 429 (2): 179-82.

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta., Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V., J Biol Chem. June 26, 1998; 273 (26): 15971-9.

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney., Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K., FEBS Lett. November 6, 1998; 438 (3): 321-4.

Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)., Race JE, Grassl SM, Williams WJ, Holtzman EJ., Biochem Biophys Res Commun. February 16, 1999; 255 (2): 508-14.

Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes., Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H., Mol Pharmacol. May 1, 1999; 55 (5): 847-54.

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H., J Biol Chem. May 7, 1999; 274 (19): 13675-80.

Transport of ochratoxin A by renal multispecific organic anion transporter 1., Tsuda M, Sekine T, Takeda M, Cha SH, Kanai Y, Kimura M, Endou H., J Pharmacol Exp Ther. June 1, 1999; 289 (3): 1301-5.

The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1., Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H., J Pharmacol Exp Ther. August 1, 1999; 290 (2): 672-7.

Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct., Pavlova A, Sakurai H, Leclercq B, Beier DR, Yu AS, Nigam SK., Am J Physiol Renal Physiol. April 1, 2000; 278 (4): F635-43.

Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells., Honscha W, Dötsch KU, Thomsen N, Petzinger E., Hepatology. June 1, 2000; 31 (6): 1296-304.

Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1., Uwai Y, Saito H, Hashimoto Y, Inui K., Eur J Pharmacol. June 16, 2000; 398 (2): 193-7.

Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs., Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H., J Pharmacol Exp Ther. September 1, 2000; 294 (3): 844-9.

Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1., Uwai Y, Saito H, Hashimoto Y, Inui KI., J Pharmacol Exp Ther. October 1, 2000; 295 (1): 261-5.

Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter., Uwai Y, Saito H, Inui K., Eur J Pharmacol. December 1, 2000; 409 (1): 31-6.

Isolation of a family of organic anion transporters from human liver and kidney., Sun W, Wu RR, van Poelje PD, Erion MD., Biochem Biophys Res Commun. May 4, 2001; 283 (2): 417-22.

Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells., Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y., J Pharmacol Exp Ther. September 1, 2001; 298 (3): 1179-84.

Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1., Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N., Mol Pharmacol. November 1, 2001; 60 (5): 1091-9.

Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone., Uwai Y, Saito H, Inui K., Drug Metab Pharmacokinet. January 1, 2002; 17 (2): 125-9.

Molecular characterization of the renal organic anion transporter 1., Burckhardt G, Wolff NA, Bahn A., Cell Biochem Biophys. January 1, 2002; 36 (2-3): 169-74.

Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1., Koh AS, Simmons-Willis TA, Pritchard JB, Grassl SM, Ballatori N., Mol Pharmacol. October 1, 2002; 62 (4): 921-6.

Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells., Aslamkhan AG, Han YH, Yang XP, Zalups RK, Pritchard JB., Mol Pharmacol. March 1, 2003; 63 (3): 590-6.

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB., Am J Physiol Renal Physiol. April 1, 2003; 284 (4): F763-9.

Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression., Béery E, Middel P, Bahn A, Willenberg HS, Hagos Y, Koepsell H, Bornstein SR, Müller GA, Burckhardt G, Steffgen J., Endocrinology. October 1, 2003; 144 (10): 4519-26.

Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells., Aslamkhan A, Han YH, Walden R, Sweet DH, Pritchard JB., Am J Physiol Renal Physiol. October 1, 2003; 285 (4): F775-83.

Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport., Bahn A, Hagos Y, Rudolph T, Burckhardt G., Biochimie. February 1, 2004; 86 (2): 133-6.

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs., Mori S, Ohtsuki S, Takanaga H, Kikkawa T, Kang YS, Terasaki T., J Neurochem. August 1, 2004; 90 (4): 931-41.

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney., Youngblood GL, Sweet DH., Am J Physiol Renal Physiol. August 1, 2004; 287 (2): F236-44.

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)., Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM., Pharmacogenet Genomics. April 1, 2005; 15 (4): 201-9.

Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])., Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T., J Pharm Pharmacol. May 1, 2005; 57 (5): 573-8.

Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells., Asif AR, Steffgen J, Metten M, Grunewald RW, Müller GA, Bahn A, Burckhardt G, Hagos Y., Pflugers Arch. May 1, 2005; 450 (2): 88-95.

Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)., Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 621-8.

Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney., Kwak JO, Kim HW, Oh KJ, Kim DS, Han KO, Cha SH., Exp Mol Med. June 30, 2005; 37 (3): 204-12.

Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)., Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB., J Pharmacol Exp Ther. August 1, 2005; 314 (2): 923-31.

The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1., Whitley AC, Sweet DH, Walle T., Drug Metab Dispos. August 1, 2005; 33 (8): 1097-100.

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice., Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK., J Biol Chem. February 24, 2006; 281 (8): 5072-83.

The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3., Aslamkhan AG, Thompson DM, Perry JL, Bleasby K, Wolff NA, Barros S, Miller DS, Pritchard JB., Am J Physiol Regul Integr Comp Physiol. December 1, 2006; 291 (6): R1773-80.

Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics., Smith NF, Marsh S, Scott-Horton TJ, Hamada A, Mielke S, Mross K, Figg WD, Verweij J, McLeod HL, Sparreboom A., Clin Pharmacol Ther. January 1, 2007; 81 (1): 76-82.

The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid., Rizwan AN, Krick W, Burckhardt G., J Biol Chem. May 4, 2007; 282 (18): 13402-9.

Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues., Nigam SK, Bush KT, Bhatnagar V., Nat Clin Pract Nephrol. August 1, 2007; 3 (8): 443-8.

Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]., Matsumoto S, Yoshida K, Ishiguro N, Maeda T, Tamai I., J Pharmacol Exp Ther. September 1, 2007; 322 (3): 1246-52.

The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin., Windass AS, Lowes S, Wang Y, Brown CD., J Pharmacol Exp Ther. September 1, 2007; 322 (3): 1221-7.

Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers., Sato M, Iwanaga T, Mamada H, Ogihara T, Yabuuchi H, Maeda T, Tamai I., Pharm Res. March 1, 2008; 25 (3): 639-46.

Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination., Truong DM, Kaler G, Khandelwal A, Swaan PW, Nigam SK., J Biol Chem. March 28, 2008; 283 (13): 8654-63.

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics., Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK., Am J Physiol Renal Physiol. April 1, 2008; 294 (4): F867-73.

Interaction of imatinib with human organic ion carriers., Hu S, Franke RM, Filipski KK, Hu C, Orwick SJ, de Bruijn EA, Burger H, Baker SD, Sparreboom A., Clin Cancer Res. May 15, 2008; 14 (10): 3141-8.

Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias., Hagos Y, Krick W, Braulke T, Mühlhausen C, Burckhardt G, Burckhardt BC., Pflugers Arch. October 1, 2008; 457 (1): 223-31.

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