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Summary Expression Phenotypes Gene Literature (129) GO Terms (7) Nucleotides (158) Proteins (40) Interactants (599) Wiki
XB--5995151

Papers associated with smad4.2



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A human Mad protein acting as a BMP-regulated transcriptional activator., Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J., Nature. June 13, 1996; 381 (6583): 620-3.

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma., Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L., Cell. August 23, 1996; 86 (4): 543-52.

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways., Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J., Nature. October 31, 1996; 383 (6603): 832-6.

Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer., Moskaluk CA, Kern SE., Biochim Biophys Acta. December 9, 1996; 1288 (3): M31-3.

Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway., Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P., J Biol Chem. January 31, 1997; 272 (5): 2896-900.

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function., Zhang Y, Musci T, Derynck R., Curr Biol. April 1, 1997; 7 (4): 270-6.

Smad5 induces ventral fates in Xenopus embryo., Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A., Dev Biol. April 15, 1997; 184 (2): 402-5.    

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4., Hata A, Lo RS, Wotton D, Lagna G, Massagué J., Nature. July 3, 1997; 388 (6637): 82-7.

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4., Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P., EMBO J. September 1, 1997; 16 (17): 5353-62.

Smad4 and FAST-1 in the assembly of activin-responsive factor., Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M., Nature. September 4, 1997; 389 (6646): 85-9.

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P., Nature. October 9, 1997; 389 (6651): 631-5.

Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads., Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW., Development. November 1, 1997; 124 (22): 4467-80.

Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase., Chen Y, Bhushan A, Vale W., Proc Natl Acad Sci U S A. November 25, 1997; 94 (24): 12938-43.          

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes., Liu F, Pouponnot C, Massagué J., Genes Dev. December 1, 1997; 11 (23): 3157-67.

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor., Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A., Genes Dev. January 15, 1998; 12 (2): 186-97.          

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line., Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K., Genes Cells. February 1, 1998; 3 (2): 125-34.

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells., Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B., Proc Natl Acad Sci U S A. March 3, 1998; 95 (5): 2412-6.

Characterization of human FAST-1, a TGF beta and activin signal transducer., Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B., Mol Cell. July 1, 1998; 2 (1): 121-7.

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2., Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L., Mol Cell. July 1, 1998; 2 (1): 109-20.

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2., Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9378-83.

Smad3 mutant mice develop metastatic colorectal cancer., Zhu Y, Richardson JA, Parada LF, Graff JM., Cell. September 18, 1998; 94 (6): 703-14.

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2., Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL., J Biol Chem. October 2, 1998; 273 (40): 25628-36.

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis., Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M., Mech Dev. December 1, 1998; 79 (1-2): 17-27.        

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor., Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL., Cell. December 11, 1998; 95 (6): 779-91.

FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals., Liu B, Dou CL, Prabhu L, Lai E., Mol Cell Biol. January 1, 1999; 19 (1): 424-30.

Spemann organizer activity of Smad10., LeSueur JA, Graff JM., Development. January 1, 1999; 126 (1): 137-46.

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3., Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K., J Biol Chem. January 8, 1999; 274 (2): 703-9.

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus., Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH., Dev Biol. March 15, 1999; 207 (2): 364-79.

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties., Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E., J Biol Chem. April 23, 1999; 274 (17): 12163-70.                

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals., Christian JL, Nakayama T., Bioessays. May 1, 1999; 21 (5): 382-90.

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation., Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH., Nature. August 12, 1999; 400 (6745): 687-93.

The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis., Yeo CY, Chen X, Whitman M., J Biol Chem. September 10, 1999; 274 (37): 26584-90.

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes., Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P, Hill CS., Dev Biol. October 15, 1999; 214 (2): 354-69.

Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding., Nagarajan RP, Liu J, Chen Y., J Biol Chem. October 29, 1999; 274 (44): 31229-35.

FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo., Watanabe M, Whitman M., Development. December 1, 1999; 126 (24): 5621-34.

Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4., Nishinakamura R, Matsumoto Y, Matsuda T, Ariizumi T, Heike T, Asashima M, Yokota T., Dev Biol. December 15, 1999; 216 (2): 481-90.              

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling., Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW., J Biol Chem. January 21, 2000; 275 (3): 2063-70.

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif., Germain S, Howell M, Esslemont GM, Hill CS., Genes Dev. February 15, 2000; 14 (4): 435-51.                

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer., Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW., Nature. February 17, 2000; 403 (6771): 781-5.

Cloning and characterization of zebrafish smad2, smad3 and smad4., Dick A, Mayr T, Bauer H, Meier A, Hammerschmidt M., Gene. April 4, 2000; 246 (1-2): 69-80.

Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers., Yanagisawa K, Uchida K, Nagatake M, Masuda A, Sugiyama M, Saito T, Yamaki K, Takahashi T, Osada H., Oncogene. May 4, 2000; 19 (19): 2305-11.

Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity., Kawai S, Faucheu C, Gallea S, Spinella-Jaegle S, Atfi A, Baron R, Roman SR., Biochem Biophys Res Commun. May 19, 2000; 271 (3): 682-7.

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB., Nagarajan RP, Chen F, Li W, Vig E, Harrington MA, Nakshatri H, Chen Y., Biochem J. June 15, 2000; 348 Pt 3 591-6.

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction., Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB., Genes Dev. July 1, 2000; 14 (13): 1605-16.            

Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter., Henningfeld KA, Rastegar S, Adler G, Knöchel W., J Biol Chem. July 21, 2000; 275 (29): 21827-35.

Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 (forkhead activin signal transducer-2)-mediated transcription., Nagarajan RP, Chen Y., Biochem J. August 15, 2000; 350 Pt 1 253-9.

Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution., Funaba M, Mathews LS., Mol Endocrinol. October 1, 2000; 14 (10): 1583-91.

Expression regulation of hyaluronan synthase in corneal endothelial cells., Usui T, Amano S, Oshika T, Suzuki K, Miyata K, Araie M, Heldin P, Yamashita H., Invest Ophthalmol Vis Sci. October 1, 2000; 41 (11): 3261-7.

Recombinant expression and purification of smad proteins., Funaba M, Mathews LS., Protein Expr Purif. December 1, 2000; 20 (3): 507-13.

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus., Pierreux CE, Nicolás FJ, Hill CS., Mol Cell Biol. December 1, 2000; 20 (23): 9041-54.

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