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Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator. , McNicholas CM, Guggino WB, Schwiebert EM, Hebert SC, Giebisch G, Egan ME., Proc Natl Acad Sci U S A. July 23, 1996; 93 (15): 8083-8.
Molecular site for nucleotide binding on an ATP-sensitive renal K+ channel (ROMK2). , McNicholas CM, Yang Y , Giebisch G, Hebert SC., Am J Physiol. August 1, 1996; 271 (2 Pt 2): F275-85.
Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro. , Sakura H, Wat N, Horton V, Millns H, Turner RC, Ashcroft FM., Diabetologia. October 1, 1996; 39 (10): 1233-6.
Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes. , Gribble FM, Ashfield R, Ammälä C, Ashcroft FM., J Physiol. January 1, 1997; 498 ( Pt 1) 87-98.
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. , Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM., Nature. May 8, 1997; 387 (6629): 179-83.
Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. , Trapp S, Tucker SJ, Ashcroft FM., Proc Natl Acad Sci U S A. August 5, 1997; 94 (16): 8872-7.
The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation. , Gribble FM, Tucker SJ, Ashcroft FM., J Physiol. October 1, 1997; 504 ( Pt 1) 35-45.
Phentolamine block of KATP channels is mediated by Kir6.2. , Proks P, Ashcroft FM., Proc Natl Acad Sci U S A. October 14, 1997; 94 (21): 11716-20.
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit. , Gribble FM, Tucker SJ, Haug T, Ashcroft FM., Proc Natl Acad Sci U S A. June 9, 1998; 95 (12): 7185-90.
Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. , Trapp S, Proks P, Tucker SJ, Ashcroft FM., J Gen Physiol. September 1, 1998; 112 (3): 333-49.
Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification. , Trapp S, Tucker SJ, Ashcroft FM., J Gen Physiol. September 1, 1998; 112 (3): 325-32.
Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. , Gribble FM, Proks P, Corkey BE, Ashcroft FM., J Biol Chem. October 9, 1998; 273 (41): 26383-7.
KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. , Drain P, Li L, Wang J ., Proc Natl Acad Sci U S A. November 10, 1998; 95 (23): 13953-8.
Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP. , Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM., J Physiol. January 1, 1999; 514 ( Pt 1) 19-25.
A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland. , Otonkoski T, Ammälä C, Huopio H, Cote GJ, Chapman J, Cosgrove K, Ashfield R, Huang E, Komulainen J, Ashcroft FM, Dunne MJ, Kere J, Thomas PM., Diabetes. February 1, 1999; 48 (2): 408-15.
Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. , Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K., J Biol Chem. February 12, 1999; 274 (7): 3931-3.
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. , Zerangue N, Schwappach B, Jan YN, Jan LY., Neuron. March 1, 1999; 22 (3): 537-48.
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide. , Gribble FM, Ashcroft FM., Diabetologia. July 1, 1999; 42 (7): 845-8.
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor. , Reimann F, Tucker SJ, Proks P, Ashcroft FM., J Physiol. July 15, 1999; 518 ( Pt 2) 325-36.
PKA-mediated phosphorylation of the human K(ATP) channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation. , Béguin P, Nagashima K, Nishimura M, Gonoi T, Seino S., EMBO J. September 1, 1999; 18 (17): 4722-32.
Interaction of vanadate with the cloned beta cell K(ATP) channel. , Proks P, Ashfield R, Ashcroft FM., J Biol Chem. September 3, 1999; 274 (36): 25393-7.
In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound. , Le Brigand L, Virsolvy A, Manechez D, Godfroid JJ, Guardiola-Lemaître B, Gribble FM, Ashcroft FM, Bataille D., Br J Pharmacol. November 1, 1999; 128 (5): 1021-6.
The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP. , Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM., J Physiol. November 1, 1999; 520 Pt 3 661-9.
Altered functional properties of KATP channel conferred by a novel splice variant of SUR1. , Sakura H, Trapp S, Liss B, Ashcroft FM., J Physiol. December 1, 1999; 521 Pt 2 337-50.
Sensitivity of Kir6.2- SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone. , McKay NG, Kinsella JM, Campbell CM, Ashford ML., Br J Pharmacol. June 1, 2000; 130 (4): 857-66.
Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/ SUR2A. , Gribble FM, Reimann F, Ashfield R, Ashcroft FM., Mol Pharmacol. June 1, 2000; 57 (6): 1256-61.
Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide. , Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K., Biochem Biophys Res Commun. June 7, 2000; 272 (2): 316-9.
Identification of molecular regions responsible for the membrane trafficking of Kir6.2. , Hough E, Beech DJ, Sivaprasadarao A., Pflugers Arch. July 1, 2000; 440 (3): 481-7.
Direct interaction of Na-azide with the KATP channel. , Trapp S, Ashcroft FM., Br J Pharmacol. November 1, 2000; 131 (6): 1105-12.
Interaction of stilbene disulphonates with cloned K(ATP) channels. , Proks P, Jones P, Ashcroft FM., Br J Pharmacol. March 1, 2001; 132 (5): 973-82.
Effects of mitiglinide (S 21403) on Kir6.2/ SUR1, Kir6.2/ SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. , Reimann F, Proks P, Ashcroft FM., Br J Pharmacol. April 1, 2001; 132 (7): 1542-8.
Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. , Song DK, Ashcroft FM., Br J Pharmacol. May 1, 2001; 133 (1): 193-9.
Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP. , Krauter T, Ruppersberg JP, Baukrowitz T., Mol Pharmacol. May 1, 2001; 59 (5): 1086-93.
Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism. , Partridge CJ, Beech DJ, Sivaprasadarao A., J Biol Chem. September 21, 2001; 276 (38): 35947-52.
Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH. , Piao H, Cui N, Xu H, Mao J, Rojas A, Wang R , Abdulkadir L, Li L, Wu J , Jiang C., J Biol Chem. September 28, 2001; 276 (39): 36673-80.
Amiloride derivatives are potent blockers of KATP channels. , Bollensdorff C, Zimmer T, Benndorf K., Naunyn Schmiedebergs Arch Pharmacol. October 1, 2001; 364 (4): 351-8.
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel. , Proks P, Capener CE, Jones P, Ashcroft FM., J Gen Physiol. October 1, 2001; 118 (4): 341-53.
Structural basis for the interference between nicorandil and sulfonylurea action. , Reimann F, Ashcroft FM, Gribble FM., Diabetes. October 1, 2001; 50 (10): 2253-9.
Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel. , Xu H, Wu J , Cui N, Abdulkadir L, Wang R , Mao J, Giwa LR, Chanchevalap S, Jiang C., J Biol Chem. October 19, 2001; 276 (42): 38690-6.
Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP. , Li L, Geng X, Drain P., J Gen Physiol. January 1, 2002; 119 (1): 105-16.
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/ SUR1 channel opener. , Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P., Diabetes. June 1, 2002; 51 (6): 1896-906.
Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. , Wu J , Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C., J Physiol. September 1, 2002; 543 (Pt 2): 495-504.
Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. , Wu J , Xu H, Yang Z, Wang Y, Mao J, Jiang C., J Membr Biol. November 15, 2002; 190 (2): 105-16.
K(ATP) channel activity is required for hatching in Xenopus embryos. , Cheng SM, Chen I, Levin M ., Dev Dyn. December 1, 2002; 225 (4): 588-91.
A threonine residue (Thr71) at the intracellular end of the M1 helix plays a critical role in the gating of Kir6.2 channels by intracellular ATP and protons. , Cui N, Wu J , Xu H, Wang R , Rojas A, Piao H, Mao J, Abdulkadir L, Li L, Jiang C., J Membr Biol. March 15, 2003; 192 (2): 111-22.
Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. , Konstas AA, Korbmacher C, Tucker SJ., Am J Physiol Cell Physiol. April 1, 2003; 284 (4): C910-7.
Identification of residues contributing to the ATP binding site of Kir6.2. , Trapp S, Haider S, Jones P, Sansom MS, Ashcroft FM., EMBO J. June 16, 2003; 22 (12): 2903-12.
Pyridine nucleotide regulation of the KATP channel Kir6.2/ SUR1 expressed in Xenopus oocytes. , Dabrowski M, Trapp S, Ashcroft FM., J Physiol. July 15, 2003; 550 (Pt 2): 357-63.
Na(+) current through KATP channels: consequences for Na(+) and K(+) fluxes during early myocardial ischemia. , Bollensdorff C, Knopp A, Biskup C, Zimmer T, Benndorf K., Am J Physiol Heart Circ Physiol. January 1, 2004; 286 (1): H283-95.
Concerted gating mechanism underlying KATP channel inhibition by ATP. , Drain P, Geng X, Li L., Biophys J. April 1, 2004; 86 (4): 2101-12.