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Summary Expression Phenotypes Gene Literature (54) GO Terms (1) Nucleotides (242) Proteins (106) Interactants (150) Wiki
XB-GENEPAGE-6259083

Papers associated with numa1



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Branched microtubule nucleation and dynein transport organize RanGTP asters in Xenopus laevis egg extract., Scrofani J, Ruhnow F, Chew WX, Normanno D, Nedelec F, Surrey T, Vernos I., Mol Biol Cell. January 1, 2024; 35 (1): ar12.

Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles., Janczyk PŁ, Żyłkiewicz E, De Hoyos H, West T, Matson DR, Choi WC, Young HMR, Derewenda ZS, Stukenberg PT., Mol Biol Cell. January 1, 2023; 34 (1): br1.  

Organelle size scaling over embryonic development., Wesley CC, Mishra S, Levy DL., Wiley Interdiscip Rev Dev Biol. September 1, 2020; 9 (5): e376.            

RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking., Ems-McClung SC, Emch M, Zhang S, Mahnoor S, Weaver LN, Walczak CE., J Cell Biol. February 3, 2020; 219 (2):                 

Induction of a Spindle-Assembly-Competent M Phase in Xenopus Egg Extracts., Bisht JS, Tomschik M, Gatlin JC., Curr Biol. April 22, 2019; 29 (8): 1273-1285.e5.              

Regulation of mitotic spindle assembly factor NuMA by Importin-β., Chang CC, Huang TL, Shimamoto Y, Tsai SY, Hsia KC., J Cell Biol. November 6, 2017; 216 (11): 3453-3462.          

The Ran-GTP gradient spatially regulates XCTK2 in the spindle., Weaver LN, Ems-McClung SC, Chen SH, Yang G, Shaw SL, Walczak CE., Curr Biol. June 1, 2015; 25 (11): 1509-14.

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration., Bernis C, Swift-Taylor B, Nord M, Carmona S, Chook YM, Forbes DJ., Mol Biol Cell. April 1, 2014; 25 (7): 992-1009.                  

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis., Petridou NI, Skourides PA., Nat Commun. January 1, 2014; 5 5240.      

Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol., Mitchison TJ, Nguyen P, Coughlin M, Groen AC., Mol Biol Cell. May 1, 2013; 24 (10): 1559-73.                  

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions., Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M., Proc Natl Acad Sci U S A. December 27, 2011; 108 (52): 20998-1003.

Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts., Halpin D, Kalab P, Wang J, Weis K, Heald R., PLoS Biol. December 1, 2011; 9 (12): e1001225.        

Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.            

A computational model predicts Xenopus meiotic spindle organization., Loughlin R, Heald R, Nédélec F., J Cell Biol. December 27, 2010; 191 (7): 1239-49.        

Directly probing the mechanical properties of the spindle and its matrix., Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED., J Cell Biol. February 22, 2010; 188 (4): 481-9.          

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity., Zhang X, Ems-McClung SC, Walczak CE., Mol Biol Cell. July 1, 2008; 19 (7): 2752-65.

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle., Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R., J Cell Biol. March 12, 2007; 176 (6): 765-70.        

A role for NuSAP in linking microtubules to mitotic chromosomes., Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW., Curr Biol. February 6, 2007; 17 (3): 230-6.

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly., Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM., Cell. November 3, 2006; 127 (3): 539-52.

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function., Chang P, Coughlin M, Mitchison TJ., Nat Cell Biol. November 1, 2005; 7 (11): 1133-9.

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly., Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R., Curr Biol. October 26, 2004; 14 (20): 1801-11.            

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles., Gaetz J, Kapoor TM., J Cell Biol. August 16, 2004; 166 (4): 465-71.          

Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro., Krauss SW, Lee G, Chasis JA, Mohandas N, Heald R., J Biol Chem. June 25, 2004; 279 (26): 27591-8.

Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles., Gehmlich K, Haren L, Merdes A., EMBO Rep. January 1, 2004; 5 (1): 97-103.

XMAP215, XKCM1, NuMA, and cytoplasmic dynein are required for the assembly and organization of the transient microtubule array during the maturation of Xenopus oocytes., Becker BE, Romney SJ, Gard DL., Dev Biol. September 15, 2003; 261 (2): 488-505.                

Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle., Stenoien DL, Sen S, Mancini MA, Brinkley BR., Cell Motil Cytoskeleton. June 1, 2003; 55 (2): 134-46.

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly., Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y., Nat Cell Biol. March 1, 2003; 5 (3): 242-8.

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division., Garrett S, Auer K, Compton DA, Kapoor TM., Curr Biol. December 10, 2002; 12 (23): 2055-9.

Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro., Krauss SW, Heald R, Lee G, Nunomura W, Gimm JA, Mohandas N, Chasis JA., J Biol Chem. November 15, 2002; 277 (46): 44339-46.

Assembly of centrosomal proteins and microtubule organization depends on PCM-1., Dammermann A, Merdes A., J Cell Biol. October 28, 2002; 159 (2): 255-66.                

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules., Haren L, Merdes A., J Cell Sci. May 1, 2002; 115 (Pt 9): 1815-24.

[Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]., Grypiotis P, Ruffatti A, Tonello M, Winzler C, Radu C, Zampieri S, Favaro M, Calligaro A, Todesco S., Reumatismo. January 1, 2002; 54 (3): 232-7.

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization., Du Q, Stukenberg PT, Macara IG., Nat Cell Biol. December 1, 2001; 3 (12): 1069-75.

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly., Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y., Science. January 26, 2001; 291 (5504): 653-6.

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly., Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K., Cell. January 12, 2001; 104 (1): 95-106.

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5., Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ., J Cell Biol. September 4, 2000; 150 (5): 975-88.                    

TPX2, A novel xenopus MAP involved in spindle pole organization., Wittmann T, Wilm M, Karsenti E, Vernos I., J Cell Biol. June 26, 2000; 149 (7): 1405-18.                    

NuMA: a nuclear protein involved in mitotic centrosome function., Zeng C., Microsc Res Tech. June 1, 2000; 49 (5): 467-77.

A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract., Steen RL, Cubizolles F, Le Guellec K, Collas P., J Cell Biol. May 1, 2000; 149 (3): 531-6.          

The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle., Mountain V, Simerly C, Howard L, Ando A, Schatten G, Compton DA., J Cell Biol. October 18, 1999; 147 (2): 351-66.                    

Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly., Kahana JA, Cleveland DW., J Cell Biol. September 20, 1999; 146 (6): 1205-10.    

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts., Zhang C, Hughes M, Clarke PR., J Cell Sci. July 1, 1999; 112 ( Pt 14) 2453-61.

NuMA is a component of an insoluble matrix at mitotic spindle poles., Dionne MA, Howard L, Compton DA., Cell Motil Cytoskeleton. January 1, 1999; 42 (3): 189-203.

Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle., Whitehead CM, Rattner JB., J Cell Sci. September 1, 1998; 111 ( Pt 17) 2551-61.

The role of NuMA in the interphase nucleus., Merdes A, Cleveland DW., J Cell Sci. January 1, 1998; 111 ( Pt 1) 71-9.

Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis., Paoletti A, Giocanti N, Favaudon V, Bornens M., J Cell Sci. October 1, 1997; 110 ( Pt 19) 2403-15.

Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes., Gaglio T, Dionne MA, Compton DA., J Cell Biol. September 8, 1997; 138 (5): 1055-66.              

A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly., Merdes A, Ramyar K, Vechio JD, Cleveland DW., Cell. November 1, 1996; 87 (3): 447-58.

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole., Gaglio T, Saredi A, Bingham JB, Hasbani MJ, Gill SR, Schroer TA, Compton DA., J Cell Biol. October 1, 1996; 135 (2): 399-414.

Two major autoantigen-antibody systems of the mitotic spindle apparatus., Andrade LE, Chan EK, Peebles CL, Tan EM., Arthritis Rheum. October 1, 1996; 39 (10): 1643-53.

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