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Summary Expression Phenotypes Gene Literature (33) GO Terms (0) Nucleotides (304) Proteins (127) Interactants (112) Wiki
XB-GENEPAGE-877003

Papers associated with wnk1



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Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression., Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castañeda-Bueno M, Alessi DR, Gamba G., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.                    

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis., Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X., J Clin Invest. December 1, 2020; 130 (12): 6379-6394.

WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration., Pacheco-Alvarez D, Carrillo-Pérez DL, Mercado A, Leyva-Ríos K, Moreno E, Hernández-Mercado E, Castañeda-Bueno M, Vázquez N, Gamba G., Am J Physiol Cell Physiol. August 1, 2020; 319 (2): C371-C380.

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC., Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama A, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D, Gamba G., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters., Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G., Am J Physiol Cell Physiol. July 1, 2016; 311 (1): C54-66.

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride., Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, González-Rodríguez X, Vázquez N, Rodríguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, García-Valdés J, Hadchouel J, Gamba G., J Am Soc Nephrol. August 1, 2015; 26 (8): 1781-6.

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4., Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J., Hypertension. November 1, 2014; 64 (5): 1047-53.

Regulation of ClC-2 activity by SPAK and OSR1., Warsi J, Hosseinzadeh Z, Elvira B, Bissinger R, Shumilina E, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 378-87.

SPAK dependent regulation of peptide transporters PEPT1 and PEPT2., Warsi J, Dong L, Elvira B, Salker MS, Shumilina E, Hosseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 388-98.

Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1., Warsi J, Elvira B, Bissinger R, Shumilina E, Hosseinzadeh Z, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (6): 591-9.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S., Biol Open. February 15, 2012; 1 (2): 120-7.              

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models., Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL., Hum Mol Genet. March 1, 2011; 20 (5): 855-66.

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL., Am J Pathol. September 1, 2009; 175 (3): 1315-27.

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M, Zuber AM, O'Shaughnessy KM., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter., San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G., Am J Physiol Renal Physiol. October 1, 2008; 295 (4): F1199-206.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases., Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. June 17, 2008; 105 (24): 8458-63.

Cotransporters, WNKs and hypertension: an update., Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex., Yang CL, Zhu X, Ellison DH., J Clin Invest. November 1, 2007; 117 (11): 3403-11.

WNK4-mediated regulation of renal ion transport proteins., Peng JB, Warnock DG., Am J Physiol Renal Physiol. October 1, 2007; 293 (4): F961-73.

SLC26A9 is a Cl(-) channel regulated by the WNK kinases., Dorwart MR, Shcheynikov N, Wang Y, Stippec S, Muallem S., J Physiol. October 1, 2007; 584 (Pt 1): 333-45.

WNK1 and WNK4 modulate CFTR activity., Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH., Biochem Biophys Res Commun. February 16, 2007; 353 (3): 535-40.

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved., Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM., Am J Physiol Renal Physiol. December 1, 2006; 291 (6): F1369-76.

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo., O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW., J Am Soc Nephrol. September 1, 2006; 17 (9): 2402-13.

WNK1 affects surface expression of the ROMK potassium channel independent of WNK4., Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.

WNK1 kinase isoform switch regulates renal potassium excretion., Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA., Proc Natl Acad Sci U S A. May 30, 2006; 103 (22): 8558-63.

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform., Subramanya AR, Yang CL, Zhu X, Ellison DH., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis., Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism., Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH., J Biol Chem. October 7, 2005; 280 (40): 34218-23.

WNK kinases and the control of blood pressure., Cope G, Golbang A, O'Shaughnessy KM., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.

[WNK1 and WNK4, new players in salt and water homeostasis], Hadchouel J, Delaloy C, Jeunemaitre X., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.

WNK kinases regulate thiazide-sensitive Na-Cl cotransport., Yang CL, Angell J, Mitchell R, Ellison DH., J Clin Invest. April 1, 2003; 111 (7): 1039-45.

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. January 21, 2003; 100 (2): 680-4.

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