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Summary Expression Gene Literature (45) GO Terms (20) Nucleotides (46) Proteins (24) Interactants (165) Wiki
XB-GENEPAGE-940129

Papers associated with hcn4

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Effect of Ginkgo biloba extract on pacemaker channels encoded by HCN gene., Chen H, Chen Y, Yang J, Wu P, Wang X, Huang C., Herz. May 20, 2020;


Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking., Erlenhardt N, Kletke O, Wohlfarth F, Komadowski MA, Clasen L, Makimoto H, Rinné S, Kelm M, Jungen C, Decher N, Meyer C, Klöcker N., Pflugers Arch. January 1, 2020; 472 (12): 1733-1742.      


Gain-of-function HCN2 variants in genetic epilepsy., Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nürnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA., Hum Mutat. January 1, 2018; 39 (2): 202-209.


In Vitro Analyses of Novel HCN4 Gene Mutations., Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S, Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E, Seebohm G., Cell Physiol Biochem. January 1, 2018; 49 (3): 1197-1207.


The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function., Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N., FASEB J. January 1, 2018; 32 (11): 6159-6173.            


Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family., Alvarez-Baron CP, Klenchin VA, Chanda B., J Gen Physiol. January 1, 2018; 150 (8): 1203-1213.            


HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner., Pai VP, Willocq V, Pitcairn EJ, Lemire JM, Paré JF, Shi NQ, McLaughlin KA, Levin M., Biol Open. October 15, 2017; 6 (10): 1445-1457.                              


Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis., Pitcairn E, Harris H, Epiney J, Pai VP, Lemire JM, Ye B, Shi NQ, Levin M, McLaughlin KA., Commun Integr Biol. January 1, 2017; 10 (3): e1309488.                            


Gabapentin Modulates HCN4 Channel Voltage-Dependence., Tae HS, Smith KM, Phillips AM, Boyle KA, Li M, Forster IC, Hatch RJ, Richardson R, Hughes DI, Graham BA, Petrou S, Reid CA., Front Pharmacol. January 1, 2017; 8 554.            


Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy., Becker F, Reid CA, Hallmann K, Tae HS, Phillips AM, Teodorescu G, Weber YG, Kleefuss-Lie A, Elger C, Perez-Reyes E, Petrou S, Kunz WS, Lerche H, Maljevic S., Epilepsia Open. January 1, 2017; 2 (3): 334-342.        


Id genes are essential for early heart formation., Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR., Genes Dev. January 1, 2017; 31 (13): 1325-1338.                


The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites., Itoh M, Ishihara K, Nakashima N, Takano M., J Physiol Sci. May 1, 2016; 66 (3): 241-8.


Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity., Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A., Stem Cells. April 1, 2015; 33 (4): 1113-29.              


Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current., Verkerk AO, Wilders R., Int J Mol Sci. January 1, 2015; 16 (2): 3071-94.        


An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities., Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N., Front Mol Neurosci. January 1, 2015; 8 63.          


Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes., Chen H, Chen Y, Tang Y, Yang J, Wang D, Yu T, Huang C., Mol Med Rep. September 1, 2014; 10 (3): 1576-82.


Cardiac arrhythmia induced by genetic silencing of ''funny'' (f) channels is rescued by GIRK4 inactivation., Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME., Nat Commun. July 8, 2014; 5 4664.                


The cAMP-binding Popdc proteins have a redundant function in the heart., Brand T, Simrick SL, Poon KL, Schindler RF., Biochem Soc Trans. April 1, 2014; 42 (2): 295-301.      


Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current., Verkerk AO, Wilders R., Europace. March 1, 2014; 16 (3): 384-95.


HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain., Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD., J Pharmacol Exp Ther. June 1, 2013; 345 (3): 363-73.


Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells., Reetz O, Strauss U., Cell Physiol Biochem. January 1, 2013; 31 (4-5): 532-41.


Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel., Xu X, Marni F, Wu S, Su Z, Musayev F, Shrestha S, Xie C, Gao W, Liu Q, Zhou L., Structure. December 5, 2012; 20 (12): 2116-23.


Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents., Chen Y, Wu P, Fan X, Chen H, Yang J, Song T, Huang C., Alcohol Clin Exp Res. December 1, 2012; 36 (12): 2036-46.


Blocking effects of acehytisine on pacemaker currents (I(f)) in sinoatrial node cells and human HCN4 channels expressed in Xenopus laevis oocytes., Fan X, Chen Y, Chen Y, Xing J, Wu P, Chen H, Yang J, Zhang J, Wang X, Huang C., J Ethnopharmacol. January 6, 2012; 139 (1): 42-51.


The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect., Netter MF, Zuzarte M, Schlichthörl G, Klöcker N, Decher N., Cell Physiol Biochem. January 1, 2012; 30 (5): 1227-40.


Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis., Jackson HA, Hegle A, Nazzari H, Jegla T, Accili EA., PLoS One. January 1, 2012; 7 (11): e47590.                


Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels., Lolicato M, Nardini M, Gazzarrini S, Möller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A., J Biol Chem. December 30, 2011; 286 (52): 44811-20.


Local anesthetic inhibits hyperpolarization-activated cationic currents., Meng QT, Xia ZY, Liu J, Bayliss DA, Chen X., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.


A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews., Laish-Farkash A, Glikson M, Brass D, Marek-Yagel D, Pras E, Dascal N, Antzelevitch C, Nof E, Reznik H, Eldar M, Luria D., J Cardiovasc Electrophysiol. December 1, 2010; 21 (12): 1365-72.


Structural basis for the cAMP-dependent gating in the human HCN4 channel., Xu X, Vysotskaya ZV, Liu Q, Zhou L., J Biol Chem. November 19, 2010; 285 (47): 37082-91.


Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift., Wicks NL, Chan KS, Madden Z, Santoro B, Young EC., Pflugers Arch. September 1, 2009; 458 (5): 877-89.


Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation., Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N., Neuron. June 25, 2009; 62 (6): 814-25.


Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes., Zhang Q, Huang A, Lin YC, Yu HG., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.


Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5., Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y., Dev Biol. March 15, 2009; 327 (2): 376-85.      


Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels., Vemana S, Pandey S, Larsson HP., Am J Physiol Cell Physiol. August 1, 2008; 295 (2): C557-65.


Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia., Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M., Circulation. July 31, 2007; 116 (5): 463-70.


Panulirus interruptus Ih-channel gene PIIH: modification of channel properties by alternative splicing and role in rhythmic activity., Ouyang Q, Goeritz M, Harris-Warrick RM., J Neurophysiol. June 1, 2007; 97 (6): 3880-92.


Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation., Ishii TM, Nakashima N, Ohmori H., J Physiol. March 1, 2007; 579 (Pt 2): 291-301.


Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels., Elinder F, Männikkö R, Pandey S, Larsson HP., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.


Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol., Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.


Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers., Azene EM, Xue T, Marbán E, Tomaselli GF, Li RA., Cardiovasc Res. August 1, 2005; 67 (2): 263-73.


Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels., Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.                      


Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels., Yu HG, Lu Z, Pan Z, Cohen IS., Pflugers Arch. January 1, 2004; 447 (4): 392-400.


KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents., Decher N, Bundis F, Vajna R, Steinmeyer K., Pflugers Arch. September 1, 2003; 446 (6): 633-40.


Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide., Chen S, Wang J, Siegelbaum SA., J Gen Physiol. May 1, 2001; 117 (5): 491-504.                  

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