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Summary Expression Gene Literature (102) GO Terms (5) Nucleotides (284) Proteins (42) Interactants (129) Wiki
XB-GENEPAGE-948121

Papers associated with arfgap1

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High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB, Refaat MM, David JP, Mujezinovic A, Calloe K, Wojciak J, Nussbaum RL, Scheinman MM, Schmitt N., Sci Rep. September 21, 2015; 5 10009.              


Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel., Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP, Elinder F., Proc Natl Acad Sci U S A. May 5, 2015; 112 (18): 5714-9.          


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN, Trudeau MC., PLoS One. January 1, 2015; 10 (4): e0123951.              


Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function., Mennerick S, Taylor AA, Zorumski CF., Psychopharmacology (Berl). September 1, 2014; 231 (17): 3493-501.


Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning., Eckey K, Wrobel E, Strutz-Seebohm N, Pott L, Schmitt N, Seebohm G., J Biol Chem. August 15, 2014; 289 (33): 22749-58.


Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology., Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A., Arterioscler Thromb Vasc Biol. July 1, 2014; 34 (7): 1522-30.


Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel., Zaydman MA, Kasimova MA, McFarland K, Beller Z, Hou P, Kinser HE, Liang H, Zhang G, Shi J, Tarek M, Cui J., Elife. March 18, 2014; 3 e03606.                        


Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening., Zaydman MA, Silva JR, Delaloye K, Li Y, Liang H, Larsson HP, Shi J, Cui J., Proc Natl Acad Sci U S A. August 6, 2013; 110 (32): 13180-5.


Cardiac channelopathy causing sudden death as revealed by molecular autopsy., Kauferstein S, Kiehne N, Peigneur S, Tytgat J, Bratzke H., Int J Legal Med. January 1, 2013; 127 (1): 145-51.


A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel., Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA., Nat Commun. January 1, 2013; 4 1784.              


Intermediate state trapping of a voltage sensor., Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F., J Gen Physiol. December 1, 2012; 140 (6): 635-52.                      


Dual effect of phosphatidylinositol [corrected] (4,5)-bisphosphate PIP(2) [corrected] on Shaker K(+) [corrected] channels., Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G., J Biol Chem. October 19, 2012; 287 (43): 36158-67.


Coexisting mutations/polymorphisms of the long QT syndrome genes in patients with repaired Tetralogy of Fallot are associated with the risks of life-threatening events., Chiu SN, Wu MH, Su MJ, Wang JK, Lin MT, Chang CC, Hsu HW, Shen CT, Thériault O, Chahine M., Hum Genet. August 1, 2012; 131 (8): 1295-304.


Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.


18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.            


Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels., Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP., Proc Natl Acad Sci U S A. May 1, 2012; 109 (18): 7103-8.


Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels., Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen SP, Abriel H, Jespersen T., Heart Rhythm. March 1, 2012; 9 (3): 440-8.


AMP-activated protein kinase downregulates Kv7.1 cell surface expression., Andersen MN, Krzystanek K, Jespersen T, Olesen SP, Rasmussen HB., Traffic. January 1, 2012; 13 (1): 143-56.


Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process., Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M., Biochim Biophys Acta. November 1, 2011; 1812 (11): 1452-9.


Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state., Larsen AP, Steffensen AB, Grunnet M, Olesen SP., Biophys J. August 17, 2011; 101 (4): 818-27.


Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients., Jons C, O-Uchi J, Moss AJ, Reumann M, Rice JJ, Goldenberg I, Zareba W, Wilde AA, Shimizu W, Kanters JK, McNitt S, Hofman N, Robinson JL, Lopes CM., Sci Transl Med. March 30, 2011; 3 (76): 76ra28.


KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function., Wu D, Pan H, Delaloye K, Cui J., Biophys J. December 1, 2010; 99 (11): 3599-608.


State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation., Wu D, Delaloye K, Zaydman MA, Nekouzadeh A, Rudy Y, Cui J., J Gen Physiol. June 1, 2010; 135 (6): 595-606.                  


Impaired stretch modulation in potentially lethal cardiac sodium channel mutants., Banderali U, Juranka PF, Clark RB, Giles WR, Morris CE., Channels (Austin). January 1, 2010; 4 (1): 12-21.


PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions., Matavel A, Medei E, Lopes CM., Channels (Austin). January 1, 2010; 4 (1): 3-11.


The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes., Blom SM, Schmitt N, Jensen HS., PLoS One. December 22, 2009; 4 (12): e8251.                  


PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors., Matavel A, Lopes CM., J Mol Cell Cardiol. May 1, 2009; 46 (5): 704-12.


Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels., Henrion U, Strutz-Seebohm N, Duszenko M, Lang F, Seebohm G., Cell Physiol Biochem. January 1, 2009; 24 (1-2): 11-6.


Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels., Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F., Circ Res. December 5, 2008; 103 (12): 1451-7.


S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels., Haitin Y, Yisharel I, Malka E, Shamgar L, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 30, 2008; 3 (4): e1935.                  


KCNE1 constrains the voltage sensor of Kv7.1 K+ channels., Shamgar L, Haitin Y, Yisharel I, Malka E, Schottelndreier H, Peretz A, Paas Y, Attali B., PLoS One. April 30, 2008; 3 (4): e1943.                    


Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis., Mancilla-Simbro C, López A, Martinez-Morales E, Soto-Perez-de-Celis E, Millan-PerezPeña L, Tsushima R, Salinas-Stefanon EM., Br J Pharmacol. February 1, 2008; 153 (3): 448-58.


Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter., Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G., Mol Pharmacol. June 1, 2007; 71 (6): 1503-11.


Small-molecule synergist of the Wnt/beta-catenin signaling pathway., Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S., Proc Natl Acad Sci U S A. May 1, 2007; 104 (18): 7444-8.


Inactivation as a new regulatory mechanism for neuronal Kv7 channels., Jensen HS, Grunnet M, Olesen SP., Biophys J. April 15, 2007; 92 (8): 2747-56.


Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel., Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson RL., J Physiol. November 1, 2006; 576 (Pt 3): 755-67.


The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes., Jensen HS, Callø K, Jespersen T, Jensen BS, Olesen SP., Brain Res Mol Brain Res. September 13, 2005; 139 (1): 52-62.


Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome., Thomas D, Wimmer AB, Karle CA, Licka M, Alter M, Khalil M, Ulmer HE, Kathöfer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J., Cardiovasc Res. August 15, 2005; 67 (3): 487-97.


Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine., Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M., J Neurosci. May 18, 2005; 25 (20): 5051-60.


The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate., Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H., Mol Pharmacol. April 1, 2005; 67 (4): 1009-17.


Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)., Thomas D, Hammerling BC, Wimmer AB, Wu K, Ficker E, Kuryshev YA, Scherer D, Kiehn J, Katus HA, Schoels W, Karle CA., Cardiovasc Res. December 1, 2004; 64 (3): 467-76.


Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome., Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.


Compound mutations: a common cause of severe long-QT syndrome., Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC., Circulation. April 20, 2004; 109 (15): 1834-41.


Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation., Wedekind H, Schwarz M, Hauenschild S, Djonlagic H, Haverkamp W, Breithardt G, Wülfing T, Pongs O, Isbrandt D, Schulze-Bahr E., Clin Genet. March 1, 2004; 65 (3): 233-41.


Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels., Thomas D, Kathofer S, Zhang W, Wu K, Wimmer AB, Zitron E, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J., Br J Pharmacol. November 1, 2003; 140 (5): 996-1002.


Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein., Kathöfer S, Röckl K, Zhang W, Thomas D, Katus H, Kiehn J, Kreye V, Schoels W, Karle C., Naunyn Schmiedebergs Arch Pharmacol. August 1, 2003; 368 (2): 119-26.


Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene., Roti EC, Myers CD, Ayers RA, Boatman DE, Delfosse SA, Chan EK, Ackerman MJ, January CT, Robertson GA., J Biol Chem. December 6, 2002; 277 (49): 47779-85.


Early embryonic expression of ion channels and pumps in chick and Xenopus development., Rutenberg J, Cheng SM, Levin M., Dev Dyn. December 1, 2002; 225 (4): 469-84.                            


The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia., Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K., Br J Pharmacol. November 1, 2002; 137 (6): 892-900.


Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK., Doolan GK, Panchal RG, Fonnes EL, Clarke AL, Williams DA, Petrou S., FASEB J. October 1, 2002; 16 (12): 1662-4.

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