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Summary Expression Gene Literature (38) GO Terms (7) Nucleotides (40) Proteins (22) Interactants (36) Wiki

Papers associated with kcnk2

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Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK., Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G., Neuron. January 1, 2019; 101 (2): 232-245.e6.

Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity., Rayaprolu V, Royal P, Stengel K, Sandoz G, Kohout SC., J Gen Physiol. January 1, 2018; 150 (5): 683-696.                        

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states., McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ., J Gen Physiol. January 1, 2016; 147 (6): 497-505.          

Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red., Braun G, Lengyel M, Enyedi P, Czirják G., Br J Pharmacol. April 1, 2015; 172 (7): 1728-38.

Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation., Kisselbach J, Seyler C, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D., Br J Pharmacol. December 1, 2014; 171 (23): 5182-94.

Vernakalant activates human cardiac K(2P)17.1 background K(+) channels., Seyler C, Schweizer PA, Zitron E, Katus HA, Thomas D., Biochem Biophys Res Commun. August 29, 2014; 451 (3): 415-20.

A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels., Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Müller R., Pflugers Arch. August 1, 2014; 466 (8): 1559-70.

Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons., Schreiner BS, Lehmann R, Thiel U, Ziemba PM, Beltrán LR, Sherkheli MA, Jeanbourquin P, Hugi A, Werner M, Gisselmann G, Hatt H., Eur J Pharmacol. April 5, 2014; 728 48-58.

Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline., Noriega-Navarro R, Lopez-Charcas O, Hernández-Enríquez B, Reyes-Gutiérrez PE, Martínez R, Landa A, Morán J, Gomora JC, Garcia-Valdes J., Neuropharmacology. April 1, 2014; 79 28-36.

The cAMP-binding Popdc proteins have a redundant function in the heart., Brand T, Simrick SL, Poon KL, Schindler RF., Biochem Soc Trans. April 1, 2014; 42 (2): 295-301.      

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Rodrigues N, Bennis K, Vivier D, Pereira V, C Chatelain F, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S., Eur J Med Chem. March 21, 2014; 75 391-402.

Cardiac expression and atrial fibrillation-associated remodeling of K₂p2.1 (TREK-1) K⁺ channels in a porcine model., Schmidt C, Wiedmann F, Tristram F, Anand P, Wenzel W, Lugenbiel P, Schweizer PA, Katus HA, Thomas D., Life Sci. March 3, 2014; 97 (2): 107-15.

Inhibition of cardiac two-pore-domain K+ (K2P) channels by the antiarrhythmic drug vernakalant--comparison with flecainide., Seyler C, Li J, Schweizer PA, Katus HA, Thomas D., Eur J Pharmacol. February 5, 2014; 724 51-7.

Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2 ₂p) channels., Schmidt C, Wiedmann F, Schweizer PA, Becker R, Katus HA, Thomas D., Eur J Pharmacol. December 5, 2013; 721 (1-3): 237-48.

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)., Beltrán L, Beltrán M, Aguado A, Gisselmann G, Hatt H., Front Pharmacol. January 1, 2013; 4 63.      

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1., Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ., Channels (Austin). November 1, 2012; 6 (6): 473-8.      

Enhancement of K2P2.1 (TREK1) background currents expressed in Xenopus oocytes by voltage-gated K+ channel β subunits., Kisselbach J, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D., Life Sci. October 5, 2012; 91 (11-12): 377-383.

Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains., Bagriantsev SN, Clark KA, Minor DL., EMBO J. August 1, 2012; 31 (15): 3297-308.            

External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter., Ma XY, Yu JM, Zhang SZ, Liu XY, Wu BH, Wei XL, Yan JQ, Sun HL, Yan HT, Zheng JQ., J Biol Chem. November 18, 2011; 286 (46): 39813-22.

TREK-1 isoforms generated by alternative translation initiation display different susceptibility to the antidepressant fluoxetine., Eckert M, Egenberger B, Döring F, Wischmeyer E., Neuropharmacology. October 1, 2011; 61 (5-6): 918-23.

Optical probing of a dynamic membrane interaction that regulates the TREK1 channel., Sandoz G, Bell SC, Isacoff EY., Proc Natl Acad Sci U S A. February 8, 2011; 108 (6): 2605-10.

Molecular mechanisms underlying membrane-potential-mediated regulation of neuronal K2P2.1 channels., Segal-Hayoun Y, Cohen A, Zilberberg N., Mol Cell Neurosci. January 1, 2010; 43 (1): 117-26.

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue., Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F., Proc Natl Acad Sci U S A. August 25, 2009; 106 (34): 14628-33.

TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices., Zhou M, Xu G, Xie M, Zhang X, Schools GP, Ma L, Kimelberg HK, Chen H., J Neurosci. July 1, 2009; 29 (26): 8551-64.

Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel., Cohen A, Sagron R, Somech E, Segal-Hayoun Y, Zilberberg N., Mol Cell Neurosci. March 1, 2009; 40 (3): 382-9.

A novel mechanism for human K2P2.1 channel gating. Facilitation of C-type gating by protonation of extracellular histidine residues., Cohen A, Ben-Abu Y, Hen S, Zilberberg N., J Biol Chem. July 11, 2008; 283 (28): 19448-55.

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium., Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SA., Neuron. June 26, 2008; 58 (6): 859-70.

Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1., Putzke C, Hanley PJ, Schlichthörl G, Preisig-Müller R, Rinné S, Anetseder M, Eckenhoff R, Berkowitz C, Vassiliou T, Wulf H, Eberhart L., Am J Physiol Cell Physiol. October 1, 2007; 293 (4): C1319-26.

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F., EMBO J. December 13, 2006; 25 (24): 5864-72.

Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels., Czirják G, Enyedi P., Mol Pharmacol. March 1, 2006; 69 (3): 1024-32.

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels., Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE., J Physiol. April 1, 2005; 564 (Pt 1): 117-29.

A plant Shaker-like K+ channel switches between two distinct gating modes resulting in either inward-rectifying or "leak" current., Dreyer I, Michard E, Lacombe B, Thibaud JB., FEBS Lett. September 14, 2001; 505 (2): 233-9.

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel., Bockenhauer D, Zilberberg N, Goldstein SA., Nat Neurosci. May 1, 2001; 4 (5): 486-91.

The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK., Meadows HJ, Chapman CG, Duckworth DM, Kelsell RE, Murdock PR, Nasir S, Rennie G, Randall AD., Dev Biol. February 16, 2001; 892 (1): 94-101.

TREK-1 is a heat-activated background K(+) channel., Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E., EMBO J. June 1, 2000; 19 (11): 2483-91.

Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel., Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG., Pflugers Arch. April 1, 2000; 439 (6): 714-22.

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M., EMBO J. June 15, 1998; 17 (12): 3297-308.

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel., Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M., EMBO J. December 16, 1996; 15 (24): 6854-62.

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