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Summary Expression Phenotypes Gene Literature (42) GO Terms (0) Nucleotides (31) Proteins (19) Interactants (79) Wiki
XB-GENEPAGE-952448

Papers associated with kcnd2



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Reverse use dependence of Kv4.2 blockade by 4-aminopyridine., Tseng GN, Jiang M, Yao JA., J Pharmacol Exp Ther. November 1, 1996; 279 (2): 865-76.

Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels., Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, Mueller AL., Mol Pharmacol. March 1, 1997; 51 (3): 491-8.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels. Implications for the study of the I(to2) current., Wang HS, Dixon JE, McKinnon D., Circ Res. November 1, 1997; 81 (5): 711-8.

Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes., Wickenden AD, Tsushima RG, Losito VA, Kaprielian R, Backx PH., Cell Physiol Biochem. January 1, 1999; 9 (1): 11-28.

[The expression of arrhythmic related genes on Xenopus oocytes for evaluation of class III antiarrhythmic drugs from ocean active material]., Xu DH, Xu SB., Yi Chuan Xue Bao. January 1, 2000; 27 (3): 195-201.

Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current., Wang H, Shi H, Zhang L, Pourrier M, Yang B, Nattel S, Wang Z., Circulation. September 5, 2000; 102 (10): 1165-71.

minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?, Zhang M, Jiang M, Tseng GN., Circ Res. May 25, 2001; 88 (10): 1012-9.

Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2., Nakamura TY, Nandi S, Pountney DJ, Artman M, Rudy B, Coetzee WA., FEBS Lett. June 22, 2001; 499 (3): 205-9.

A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents., Nakamura TY, Pountney DJ, Ozaita A, Nandi S, Ueda S, Rudy B, Coetzee WA., Proc Natl Acad Sci U S A. October 23, 2001; 98 (22): 12808-13.

PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex., Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD., J Neurosci. December 1, 2002; 22 (23): 10123-33.

Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2., Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA., J Biol Chem. February 13, 2004; 279 (7): 5549-54.

Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents., Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD., J Neurosci. April 7, 2004; 24 (14): 3643-54.

Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)., Jerng HH, Qian Y, Pfaffinger PJ., Biophys J. October 1, 2004; 87 (4): 2380-96.

Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels., Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ, Covarrubias M., J Gen Physiol. July 1, 2005; 126 (1): 55-69.                    

A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels., Herrera D, Mamarbachi A, Simoes M, Parent L, Sauvé R, Wang Z, Nattel S., Mol Pharmacol. August 1, 2005; 68 (2): 305-16.

Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties., Jerng HH, Kunjilwar K, Pfaffinger PJ., J Physiol. November 1, 2005; 568 (Pt 3): 767-88.

1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers., Gordon E, Cohen JL, Engel R, Abbott GW., Mol Pharmacol. March 1, 2006; 69 (3): 718-26.

ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit., Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD., Am J Physiol Cell Physiol. March 1, 2006; 290 (3): C852-61.

A dipeptidyl aminopeptidase-like protein remodels gating charge dynamics in Kv4.2 channels., Dougherty K, Covarrubias M., J Gen Physiol. December 1, 2006; 128 (6): 745-53.            

Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels., Yuan C, Yang S, Liao Z, Liang S., Biochem Biophys Res Commun. January 19, 2007; 352 (3): 799-804.

Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats., Goltz D, Schultz JH, Stucke C, Wagner M, Bassalaý P, Schwoerer AP, Ehmke H, Volk T., Cardiovasc Res. April 1, 2007; 74 (1): 85-95.

Molecular and functional characterization of Kv4.2 and KChIP2 expressed in the porcine left ventricle., Schultz JH, Volk T, Bassalaý P, Hennings JC, Hübner CA, Ehmke H., Pflugers Arch. May 1, 2007; 454 (2): 195-207.

Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating., Yamakawa T, Saith S, Li Y, Gao X, Gaisano HY, Tsushima RG., Biochemistry. September 25, 2007; 46 (38): 10942-9.

Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels., Yuan C, Liao Z, Zeng X, Dai L, Kuang F, Liang S., Toxicon. October 1, 2007; 50 (5): 646-52.

I SA channel complexes include four subunits each of DPP6 and Kv4.2., Soh H, Goldstein SA., J Biol Chem. May 30, 2008; 283 (22): 15072-7.

Kv4.2 is a locus for PKC and ERK/MAPK cross-talk., Schrader LA, Ren Y, Cheng F, Bui D, Sweatt JD, Anderson AE., Biochem J. February 1, 2009; 417 (3): 705-15.

Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels., Barghaan J, Bähring R., J Gen Physiol. February 1, 2009; 133 (2): 205-24.                    

The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels., Kaulin YA, De Santiago-Castillo JA, Rocha CA, Nadal MS, Rudy B, Covarrubias M., J Neurosci. March 11, 2009; 29 (10): 3242-51.

A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism., Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ., Channels (Austin). November 1, 2009; 3 (6): 448-61.

Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization., Tanaka H, Namekata I, Hamaguchi S, Kawamura T, Masuda H, Tanaka Y, Iida-Tanaka N, Takahara A., Biol Pharm Bull. January 1, 2010; 33 (1): 138-41.

Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells., Jerng HH, Pfaffinger PJ., PLoS One. January 1, 2012; 7 (6): e38205.              

Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1., Bonnard C, Strobl AC, Shboul M, Lee H, Merriman B, Nelson SF, Ababneh OH, Uz E, Güran T, Kayserili H, Hamamy H, Reversade B., Nat Genet. May 13, 2012; 44 (6): 709-13.    

Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels., Fineberg JD, Ritter DM, Covarrubias M., J Gen Physiol. November 1, 2012; 140 (5): 513-27.                      

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels., Heler R, Bell JK, Boland LM., Channels (Austin). January 1, 2013; 7 (2): 74-84.              

S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation., Jerng HH, Pfaffinger PJ., PLoS One. January 1, 2014; 9 (3): e93315.                      

Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State Inactivation., Wollberg J, Bähring R., Biophys J. January 5, 2016; 110 (1): 157-75.

Genesis of the vertebrate FoxP subfamily member genes occurred during two ancestral whole genome duplication events., Song X, Tang Y, Wang Y., Gene. August 22, 2016; 588 (2): 156-62.

Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening., Lin MA, Cannon SC, Papazian DM., Proc Natl Acad Sci U S A. April 10, 2018; 115 (15): E3559-E3568.

Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel., Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS., Circ Genom Precis Med. November 1, 2018; 11 (11): e002293.

KCND2 variants associated with global developmental delay differentially impair Kv4.2 channel gating., Zhang Y, Tachtsidis G, Schob C, Koko M, Hedrich UBS, Lerche H, Lemke JR, van Haeringen A, Ruivenkamp C, Prescott T, Tveten K, Gerstner T, Pruniski B, DiTroia S, VanNoy GE, Rehm HL, McLaughlin H, Bolz HJ, Zechner U, Bryant E, McDonough T, Kindler S, Bähring R., Hum Mol Genet. November 16, 2021; 30 (23): 2300-2314.

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