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Summary Expression Phenotypes Gene Literature (52) GO Terms (1) Nucleotides (99) Proteins (47) Interactants (230) Wiki
XB-GENEPAGE-957955

Papers associated with mre11



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Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts., Tatsukawa K, Sakamoto R, Kawasoe Y, Kubota Y, Tsurimoto T, Takahashi TS, Ohashi E., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.                  

Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1., Colding-Christensen CS, Kakulidis ES, Arroyo-Gomez J, Hendriks IA, Arkinson C, Fábián Z, Gambus A, Mailand N, Duxin JP, Nielsen ML., Nat Commun. December 14, 2023; 14 (1): 8293.        

POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps., Mann A, Ramirez-Otero MA, De Antoni A, Hanthi YW, Sannino V, Baldi G, Falbo L, Schrempf A, Bernardo S, Loizou J, Costanzo V., Mol Cell. November 17, 2022; 82 (22): 4218-4231.e8.                              

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks., Montales K, Ruis K, Lindsay H, Michael WM., PLoS One. August 2, 2022; 17 (8): e0271905.                

Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress., Hashimoto Y, Tanaka H., Life Sci Alliance. March 15, 2022; 5 (6):


Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system., Montales K, Kim A, Ruis K, Michael WM., Sci Rep. January 11, 2021; 11 (1): 467.                

Conservation and divergence of protein pathways in the vertebrate heart., Federspiel JD, Tandon P, Wilczewski CM, Wasson L, Herring LE, Venkatesh SS, Cristea IM, Conlon FL., PLoS Biol. September 6, 2019; 17 (9): e3000437.                                                    

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair., Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J., Nature. July 1, 2018; 559 (7712): 61-66.                              

Dna2 initiates resection at clean DNA double-strand breaks., Paudyal SC, Li S, Yan H, Hunter T, You Z., Nucleic Acids Res. November 16, 2017; 45 (20): 11766-11781.            

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection., Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V, Krejčí L., Cell Rep. October 10, 2017; 21 (2): 333-340.                

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments., Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V., Mol Cell. September 7, 2017; 67 (5): 867-881.e7.                

Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts., Holden J, Taylor EM, Lindsay HD., PLoS One. July 10, 2017; 12 (7): e0181131.            

Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response., Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X., Cancer Res. June 15, 2017; 77 (12): 3169-3180.

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses., Choi SH, Yoo HY., Biochem Biophys Res Commun. October 7, 2016; 479 (1): 5-11.

Xenopus Mcm10 is a CDK-substrate required for replication fork stability., Chadha GS, Gambus A, Gillespie PJ, Blow JJ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.            

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair., Liao S, Tammaro M, Yan H., Nucleic Acids Res. July 8, 2016; 44 (12): 5689-701.              

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex., Lee KY, Im JS, Shibata E, Park J, Handa N, Kowalczykowski SC, Dutta A., Nat Commun. July 28, 2015; 6 7744.              

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining., Soni A, Siemann M, Grabos M, Murmann T, Pantelias GE, Iliakis G., Nucleic Acids Res. June 1, 2014; 42 (10): 6380-92.            

Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11., Chen C, Zhang L, Huang NJ, Huang B, Kornbluth S., Proc Natl Acad Sci U S A. December 17, 2013; 110 (51): 20605-10.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

A role for the MRN complex in ATR activation via TOPBP1 recruitment., Duursma AM, Driscoll R, Elias JE, Cimprich KA., Mol Cell. April 11, 2013; 50 (1): 116-22.

The MRN-CtIP pathway is required for metaphase chromosome alignment., Rozier L, Guo Y, Peterson S, Sato M, Baer R, Gautier J, Mao Y., Mol Cell. March 28, 2013; 49 (6): 1097-107.

Analysis of MRE11's function in the 5'-->3' processing of DNA double-strand breaks., Liao S, Guay C, Toczylowski T, Yan H., Nucleic Acids Res. May 1, 2012; 40 (10): 4496-506.                

Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice., Chiruvella KK, Sebastian R, Sharma S, Karande AA, Choudhary B, Raghavan SC., J Mol Biol. March 30, 2012; 417 (3): 197-211.

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts., Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell Cycle. March 15, 2012; 11 (6): 1183-94.

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks., Hashimoto Y, Puddu F, Costanzo V., Nat Struct Mol Biol. December 4, 2011; 19 (1): 17-24.          

Brca2, Rad51 and Mre11: performing balancing acts on replication forks., Costanzo V., DNA Repair (Amst). October 10, 2011; 10 (10): 1060-5.

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair., Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J., J Cell Biol. September 5, 2011; 194 (5): 705-20.              

CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts., Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG., Cell Cycle. February 1, 2011; 10 (3): 469-80.

Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repair., Yan H, Toczylowski T, McCane J, Chen C, Liao S., J Cell Biol. January 24, 2011; 192 (2): 251-61.              

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis., Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V., Nat Struct Mol Biol. November 1, 2010; 17 (11): 1305-11.          

Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM., Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG, Campbell JL., Cell Cycle. March 15, 2010; 9 (6): 1156-66.

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis., Taylor EM, Cecillon SM, Bonis A, Chapman JR, Povirk LF, Lindsay HD., Nucleic Acids Res. January 1, 2010; 38 (2): 441-54.        

CtIP links DNA double-strand break sensing to resection., You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T., Mol Cell. December 25, 2009; 36 (6): 954-69.

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin., Di Virgilio M, Ying CY, Gautier J., DNA Repair (Amst). November 2, 2009; 8 (11): 1311-20.

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. May 1, 2009; 20 (9): 2351-60.

Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends., Liao S, Toczylowski T, Yan H., Nucleic Acids Res. November 1, 2008; 36 (19): 6091-100.              

Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G., J Mol Biol. August 29, 2008; 381 (2): 361-72.

Ku80 removal from DNA through double strand break-induced ubiquitylation., Postow L, Ghenoiu C, Woo EM, Krutchinsky AN, Chait BT, Funabiki H., J Cell Biol. August 11, 2008; 182 (3): 467-79.                

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity., Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V., EMBO J. July 23, 2008; 27 (14): 1953-62.              

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex., Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J., Nat Chem Biol. February 1, 2008; 4 (2): 119-25.

Telomere capping and cellular checkpoints: clues from fruit flies., Ciapponi L, Cenci G., Cytogenet Genome Res. January 1, 2008; 122 (3-4): 365-73.

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes., Bhaskara V, Dupré A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT., Mol Cell. March 9, 2007; 25 (5): 647-61.

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex., Dupré A, Boyer-Chatenet L, Gautier J., Nat Struct Mol Biol. May 1, 2006; 13 (5): 451-7.

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks., Trenz K, Smith E, Smith S, Costanzo V., EMBO J. April 19, 2006; 25 (8): 1764-74.

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11., Di Virgilio M, Gautier J., J Cell Biol. December 5, 2005; 171 (5): 765-71.        

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1., You Z, Chahwan C, Bailis J, Hunter T, Russell P., Mol Cell Biol. July 1, 2005; 25 (13): 5363-79.

Mre11 assembles linear DNA fragments into DNA damage signaling complexes., Costanzo V, Paull T, Gottesman M, Gautier J., PLoS Biol. May 1, 2004; 2 (5): E110.          

Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei., Robinson NP, McCulloch R, Conway C, Browitt A, Barry JD., J Biol Chem. July 19, 2002; 277 (29): 26185-93.

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