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Summary Expression Phenotypes Gene Literature (77) GO Terms (13) Nucleotides (307) Proteins (54) Interactants (198) Wiki
XB--975312

Papers associated with slc1a3



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Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain., Storck T, Schulte S, Hofmann K, Stoffel W., Proc Natl Acad Sci U S A. November 15, 1992; 89 (22): 10955-9.

Electrogenic L-glutamate uptake in Xenopus laevis oocytes expressing a cloned rat brain L-glutamate/L-aspartate transporter (GLAST-1)., Klöckner U, Storck T, Conradt M, Stoffel W., J Biol Chem. July 15, 1993; 268 (20): 14594-6.

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex., Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG., J Neurosci. September 1, 1994; 14 (9): 5559-69.

Functional properties and substrate specificity of the cloned L-glutamate/L-aspartate transporter GLAST-1 from rat brain expressed in Xenopus oocytes., Klöckner U, Storck T, Conradt M, Stoffel W., J Neurosci. October 1, 1994; 14 (10): 5759-65.

Mammalian ion-coupled solute transporters., Hediger MA, Kanai Y, You G, Nussberger S., J Physiol. January 1, 1995; 482 7S-17S.

Cloning and expression of a bovine glutamate transporter., Inoue K, Sakaitani M, Shimada S, Tohyama M., Brain Res Mol Brain Res. February 1, 1995; 28 (2): 343-8.

Differential modulation of human glutamate transporter subtypes by arachidonic acid., Zerangue N, Arriza JL, Amara SG, Kavanaugh MP., J Biol Chem. March 24, 1995; 270 (12): 6433-5.

Localization of N-glycosylation sites and functional role of the carbohydrate units of GLAST-1, a cloned rat brain L-glutamate/L-aspartate transporter., Conradt M, Storck T, Stoffel W., Eur J Biochem. May 1, 1995; 229 (3): 682-7.

Constitutive ion fluxes and substrate binding domains of human glutamate transporters., Vandenberg RJ, Arriza JL, Amara SG, Kavanaugh MP., J Biol Chem. July 28, 1995; 270 (30): 17668-71.

Rat and human glutamate transporter GLAST1 stable heterologous expression, biochemical and functional characterization., Stoffel W, Blau R., Biol Chem Hoppe Seyler. August 1, 1995; 376 (8): 511-4.

Functional analysis of the high affinity, Na(+)-dependent glutamate transporter GLAST-1 by site-directed mutagenesis., Conradt M, Stoffel W., J Biol Chem. October 20, 1995; 270 (42): 25207-12.

Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1)., Dowd LA, Coyle AJ, Rothstein JD, Pritchett DB, Robinson MB., Mol Pharmacol. March 1, 1996; 49 (3): 465-73.

Interaction of L-cysteine with a human excitatory amino acid transporter., Zerangue N, Kavanaugh MP., J Physiol. June 1, 1996; 493 ( Pt 2) 419-23.

Membrane topology of the high-affinity L-glutamate transporter (GLAST-1) of the central nervous system., Wahle S, Stoffel W., J Cell Biol. December 1, 1996; 135 (6 Pt 2): 1867-77.

Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation., Conradt M, Stoffel W., J Neurochem. March 1, 1997; 68 (3): 1244-51.

Abolition of substrate-dependent currents by tyrosine mutation in the transmembrane domain of glutamate transporter., Choi I, Chiu SY., FEBS Lett. March 24, 1997; 405 (2): 133-6.

Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2., Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GA., Mol Pharmacol. May 1, 1997; 51 (5): 809-15.

New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter., Lebrun B, Sakaitani M, Shimamoto K, Yasuda-Kamatani Y, Nakajima T., J Biol Chem. August 15, 1997; 272 (33): 20336-9.

Inhibitory activity of a naturally occurring heterocyclic beta-substituted alanine, beta-(isoxazolin-5-on-4-yl)-L-alanine, on the L-glutamate/L-aspartate transporter (GLAST) expressed in Xenopus oocytes., Kusama-Eguchi K, Kusama T, Ikegami F, Lambein F, Watanabe K., Brain Res Mol Brain Res. December 1, 1997; 52 (1): 166-9.

DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters., Shimamoto K, Lebrun B, Yasuda-Kamatani Y, Sakaitani M, Shigeri Y, Yumoto N, Nakajima T., Mol Pharmacol. February 1, 1998; 53 (2): 195-201.

Serine-O-sulphate transport by the human glutamate transporter, EAAT2., Vandenberg RJ, Mitrovic AD, Johnston GA., Br J Pharmacol. April 1, 1998; 123 (8): 1593-600.

Localization and function of five glutamate transporters cloned from the salamander retina., Eliasof S, Arriza JL, Leighton BH, Amara SG, Kavanaugh MP., Vision Res. May 1, 1998; 38 (10): 1443-54.

Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2., Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ., J Biol Chem. June 12, 1998; 273 (24): 14698-706.

Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions., Vandenberg RJ, Mitrovic AD, Johnston GA., Mol Pharmacol. July 1, 1998; 54 (1): 189-96.

Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel., Wadiche JI, Kavanaugh MP., J Neurosci. October 1, 1998; 18 (19): 7650-61.

Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters., Koch HP, Kavanaugh MP, Esslinger CS, Zerangue N, Humphrey JM, Amara SG, Chamberlin AR, Bridges RJ., Mol Pharmacol. December 1, 1999; 56 (6): 1095-104.

Inherited defects of sodium-dependent glutamate transport mediated by glutamate/aspartate transporter in canine red cells due to a decreased level of transporter protein expression., Sato K, Inaba M, Suwa Y, Matsuu A, Hikasa Y, Ono K, Kagota K., J Biol Chem. March 3, 2000; 275 (9): 6620-7.

Loss of cell viability by histidine substitution of leucine 325 of the glutamate transporter EAAT1., Choi I, Chiu SY., Biochem Biophys Res Commun. August 28, 2000; 275 (2): 382-5.

Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes., MacAulay N, Gether U, Klaerke DA, Zeuthen T., J Physiol. February 1, 2001; 530 (Pt 3): 367-78.

Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems., Eliasof S, McIlvain HB, Petroski RE, Foster AC, Dunlop J., J Neurochem. April 1, 2001; 77 (2): 550-7.

Cloning and characterization of excitatory amino acid transporters GLT-1 and EAAC1 in canine brain., Sato K, Inaba M, Baba K, Tamahara S, Koshino I, Hikasa Y, Ono K, Kagota K., J Vet Med Sci. September 1, 2001; 63 (9): 997-1002.

Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)., Shigeri Y, Shimamoto K, Yasuda-Kamatani Y, Seal RP, Yumoto N, Nakajima T, Amara SG., J Neurochem. October 1, 2001; 79 (2): 297-302.

Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes., MacAulay N, Gether U, Klaeke DA, Zeuthen T., J Physiol. August 1, 2002; 542 (Pt 3): 817-28.

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B., Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F., J Neurochem. September 1, 2003; 86 (5): 1181-8.

WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake., Dunlop J, Eliasof S, Stack G, McIlvain HB, Greenfield A, Kowal D, Petroski R, Carrick T., Br J Pharmacol. November 1, 2003; 140 (5): 839-46.

The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway., Ryan RM, Mitrovic AD, Vandenberg RJ., J Biol Chem. May 14, 2004; 279 (20): 20742-51.

Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3., Boehmer C, Rajamanickam J, Schniepp R, Kohler K, Wulff P, Kuhl D, Palmada M, Lang F., Biochem Biophys Res Commun. April 8, 2005; 329 (2): 738-42.

Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2., Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J., Mol Pharmacol. October 1, 2005; 68 (4): 974-82.

The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3., Esslinger CS, Agarwal S, Gerdes J, Wilson PA, Davis ES, Awes AN, O'Brien E, Mavencamp T, Koch HP, Poulsen DJ, Rhoderick JF, Chamberlin AR, Kavanaugh MP, Bridges RJ., Neuropharmacology. November 1, 2005; 49 (6): 850-61.

Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel., Huang S, Vandenberg RJ., Biochemistry. August 28, 2007; 46 (34): 9685-92.

Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance., Torres-Salazar D, Fahlke C., J Biol Chem. November 30, 2007; 282 (48): 34719-26.

The role of cation binding in determining substrate selectivity of glutamate transporters., Huang S, Ryan RM, Vandenberg RJ., J Biol Chem. February 13, 2009; 284 (7): 4510-5.

TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices., Zhou M, Xu G, Xie M, Zhang X, Schools GP, Ma L, Kimelberg HK, Chen H., J Neurosci. July 1, 2009; 29 (26): 8551-64.

Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids., Habjan S, Vandenberg RJ., Neurochem Res. October 1, 2009; 34 (10): 1738-47.

Two non-steroidal anti-inflammatory drugs, niflumic acid and diclofenac, inhibit the human glutamate transporter EAAT1 through different mechanisms., Takahashi K, Ishii-Nozawa R, Takeuchi K, Nakazawa K, Sato K., J Pharmacol Sci. January 1, 2010; 112 (1): 113-7.

The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1., Ryan RM, Kortt NC, Sirivanta T, Vandenberg RJ., J Neurochem. July 1, 2010; 114 (2): 565-75.

Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse., Sun W, Hoffman KM, Holley DC, Kavanaugh MP., PLoS One. January 1, 2011; 6 (8): e23765.          

Regulation of the glutamate transporters by JAK2., Hosseinzadeh Z, Bhavsar SK, Sopjani M, Alesutan I, Saxena A, Dërmaku-Sopjani M, Lang F., Cell Physiol Biochem. January 1, 2011; 28 (4): 693-702.

Hetero-oligomerization of neuronal glutamate transporters., Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C., J Biol Chem. February 4, 2011; 286 (5): 3935-43.

Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking., Nissen-Meyer LS, Popescu MC, Hamdani el H, Chaudhry FA., J Neurosci. April 27, 2011; 31 (17): 6565-75.

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