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Summary Expression Phenotypes Gene Literature (64) GO Terms (5) Nucleotides (76) Proteins (37) Interactants (69) Wiki
XB-GENEPAGE-981915

Papers associated with wnk4



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Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression., Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castañeda-Bueno M, Alessi DR, Gamba G., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.                    

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis., Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X., J Clin Invest. December 1, 2020; 130 (12): 6379-6394.

WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration., Pacheco-Alvarez D, Carrillo-Pérez DL, Mercado A, Leyva-Ríos K, Moreno E, Hernández-Mercado E, Castañeda-Bueno M, Vázquez N, Gamba G., Am J Physiol Cell Physiol. August 1, 2020; 319 (2): C371-C380.

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC., Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama A, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D, Gamba G., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway., Bazúa-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, Murillo-de-Ozores AR, González-Mariscal L, Ellison DH, Riccardi D, Bobadilla NA, Gamba G., J Am Soc Nephrol. July 1, 2018; 29 (7): 1838-1848.

Phosphoregulation of K+ -Cl- cotransporters during cell swelling: Novel insights., Frenette-Cotton R, Marcoux AA, Garneau AP, Noel M, Isenring P., J Cell Physiol. January 1, 2018; 233 (1): 396-408.

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation., Murthy M, Kurz T, O'Shaughnessy KM., Physiol Rep. July 1, 2016; 4 (13):             

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride., Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, González-Rodríguez X, Vázquez N, Rodríguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, García-Valdés J, Hadchouel J, Gamba G., J Am Soc Nephrol. August 1, 2015; 26 (8): 1781-6.

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4., Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J., Hypertension. November 1, 2014; 64 (5): 1047-53.

WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathway., Yue P, Zhang C, Lin DH, Sun P, Wang WH., Biochim Biophys Acta. October 1, 2013; 1833 (10): 2101-10.

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination., Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC., Am J Physiol Renal Physiol. July 1, 2013; 305 (1): F31-41.

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation., Wu G, Peng JB., FEBS Lett. June 19, 2013; 587 (12): 1717-22.

WNK4 is an essential effector of anterior formation in FGF signaling., Shimizu M, Goto T, Sato A, Shibuya H., Genes Cells. June 1, 2013; 18 (6): 442-9.        

Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites., Na T, Wu G, Zhang W, Dong WJ, Peng JB., Am J Physiol Renal Physiol. January 1, 2013; 304 (1): F8-F18.

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process., Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G., Proc Natl Acad Sci U S A. May 15, 2012; 109 (20): 7929-34.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S., Biol Open. February 15, 2012; 1 (2): 120-7.              

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters., Acuña R, Martínez-de-la-Maza L, Ponce-Coria J, Vázquez N, Ortal-Vite P, Pacheco-Alvarez D, Bobadilla NA, Gamba G., J Hypertens. March 1, 2011; 29 (3): 475-83.

Concerted actions of NHERF2 and WNK4 in regulating TRPV5., Jing H, Na T, Zhang W, Wu G, Liu C, Peng JB., Biochem Biophys Res Commun. January 28, 2011; 404 (4): 979-84.

Functional insights into the activation mechanism of Ste20-related kinases., Gagnon KB, Rios K, Delpire E., Cell Physiol Biochem. January 1, 2011; 28 (6): 1219-30.

The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4., Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM., Can J Physiol Pharmacol. October 1, 2010; 88 (10): 986-95.

Molecular determinants of hyperosmotically activated NKCC1-mediated K+/K+ exchange., Gagnon KB, Delpire E., J Physiol. September 15, 2010; 588 (Pt 18): 3385-96.

A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190., Glover M, Sweeny C, Davis B, O'Shaughnessy KM., Open Med Chem J. September 3, 2010; 4 57-61.        

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity., Gagnon KB, Delpire E., Am J Physiol Cell Physiol. September 1, 2010; 299 (3): C614-20.

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway., Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, Zhu X, Yang CL, Ellison DH., J Clin Invest. September 1, 2009; 119 (9): 2601-12.

WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction., Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA., J Biol Chem. July 3, 2009; 284 (27): 18471-80.

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M, Zuber AM, O'Shaughnessy KM., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway., San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G., Proc Natl Acad Sci U S A. March 17, 2009; 106 (11): 4384-9.

The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK., Murthy M, Cope G, O'Shaughnessy KM., Biochem Biophys Res Commun. October 31, 2008; 375 (4): 651-4.

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane., Jiang Y, Cong P, Williams SR, Zhang W, Na T, Ma HP, Peng JB., Biochem Biophys Res Commun. October 17, 2008; 375 (2): 225-9.

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter., San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G., Am J Physiol Renal Physiol. October 1, 2008; 295 (4): F1199-206.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases., Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. June 17, 2008; 105 (24): 8458-63.

A novel protein kinase signaling pathway essential for blood pressure regulation in humans., Kahle KT, Rinehart J, Giebisch G, Gamba G, Hebert SC, Lifton RP., Trends Endocrinol Metab. April 1, 2008; 19 (3): 91-5.

Cotransporters, WNKs and hypertension: an update., Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex., Yang CL, Zhu X, Ellison DH., J Clin Invest. November 1, 2007; 117 (11): 3403-11.

WNK4-mediated regulation of renal ion transport proteins., Peng JB, Warnock DG., Am J Physiol Renal Physiol. October 1, 2007; 293 (4): F961-73.

SLC26A9 is a Cl(-) channel regulated by the WNK kinases., Dorwart MR, Shcheynikov N, Wang Y, Stippec S, Muallem S., J Physiol. October 1, 2007; 584 (Pt 1): 333-45.

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families., Keszei AP, Tislér A, Backx PH, Andrulis IL, Bull SB, Logan AG., J Hypertens. October 1, 2007; 25 (10): 2074-81.

Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation., Gagnon KB, England R, Diehl L, Delpire E., Am J Physiol Cell Physiol. May 1, 2007; 292 (5): C1809-15.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo., Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4020-4.

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis., Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.

WNK1 and WNK4 modulate CFTR activity., Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH., Biochem Biophys Res Commun. February 16, 2007; 353 (3): 535-40.

WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4., Jiang Y, Ferguson WB, Peng JB., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.

A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter., Gagnon KB, England R, Delpire E., Cell Physiol Biochem. January 1, 2007; 20 (1-4): 131-42.

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved., Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM., Am J Physiol Renal Physiol. December 1, 2006; 291 (6): F1369-76.

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo., O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW., J Am Soc Nephrol. September 1, 2006; 17 (9): 2402-13.

WNK1 affects surface expression of the ROMK potassium channel independent of WNK4., Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells., Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB., Kidney Int. June 1, 2006; 69 (12): 2162-70.

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)., Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.

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