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Summary Expression Phenotypes Gene Literature (26) GO Terms (7) Nucleotides (55) Proteins (34) Interactants (117) Wiki
XB-GENEPAGE-985798

Papers associated with f2r



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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain., Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW., J Biol Chem. May 29, 2015; 290 (22): 13875-87.

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase., Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S., Pflugers Arch. April 1, 2015; 467 (4): 687-701.

Getting to know your neighbor: cell polarization in early embryos., Nance J., J Cell Biol. September 29, 2014; 206 (7): 823-32.          

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4., Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW., J Biol Chem. September 26, 2014; 289 (39): 27215-27234.

Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells., Ghil S, McCoy KL, Hepler JR., PLoS One. January 1, 2014; 9 (4): e95355.          

Plasma membrane events associated with the meiotic divisions in the amphibian oocyte: insights into the evolution of insulin transduction systems and cell signaling., Morrill GA, Kostellow AB, Moore RD, Gupta RK., BMC Dev Biol. January 23, 2013; 13 3.              

Signaling crosstalk between TGFβ and Dishevelled/Par1b., Mamidi A, Inui M, Manfrin A, Soligo S, Enzo E, Aragona M, Cordenonsi M, Wessely O, Dupont S, Piccolo S., Cell Death Differ. October 1, 2012; 19 (10): 1689-97.                    

Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity., Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E., Am J Pathol. August 1, 2012; 181 (2): 605-15.

hnRNP K post-transcriptionally co-regulates multiple cytoskeletal genes needed for axonogenesis., Liu Y, Szaro BG., Development. July 1, 2011; 138 (14): 3079-90.                

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology., McCoy KL, Traynelis SF, Hepler JR., Mol Pharmacol. June 1, 2010; 77 (6): 1005-15.

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors., Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF., J Biol Chem. May 8, 2009; 284 (19): 12862-73.

PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC., Ossipova O, Tabler J, Green JB, Sokol SY., Development. December 1, 2007; 134 (23): 4297-306.          

Indirect activation of the epithelial Na+ channel by trypsin., Bengrine A, Li J, Hamm LL, Awayda MS., J Biol Chem. September 14, 2007; 282 (37): 26884-26896.

Apical-basal polarity, Wnt signaling and vertebrate organogenesis., Karner C, Wharton KA, Carroll TJ., Semin Cell Dev Biol. April 1, 2006; 17 (2): 214-22.      

Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region., Park SH, Shin YK, Suh YH, Park WS, Ban YL, Choi HS, Park HJ, Jung KC., Gene. July 4, 2005; 353 (2): 177-88.      

Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes., Waxman JS, Hocking AM, Stoick CL, Moon RT., Development. December 1, 2004; 131 (23): 5909-21.

Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues., Xia XM, Ding JP, Lingle CJ., J Gen Physiol. February 1, 2003; 121 (2): 125-48.                                

Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis., Ossipova O, He X, Green J., Mech Dev. December 1, 2002; 119 Suppl 1 S143-8.    

Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide., Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM, Reynolds EE, Oksenberg D., Mol Pharmacol. December 1, 2000; 58 (6): 1178-87.

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates., Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS., J Biol Chem. August 25, 2000; 275 (34): 26333-42.

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa., Camerer E, Huang W, Coughlin SR., Proc Natl Acad Sci U S A. May 9, 2000; 97 (10): 5255-60.

Cathepsin G activates protease-activated receptor-4 in human platelets., Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR., J Biol Chem. March 10, 2000; 275 (10): 6819-23.

A dual thrombin receptor system for platelet activation., Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR., Nature. August 13, 1998; 394 (6694): 690-4.

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides., Hollenberg MD, Saifeddine M, al-Ani B, Kawabata A., Can J Physiol Pharmacol. July 1, 1997; 75 (7): 832-41.

Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2)., Kawabata A, Saifeddine M, al-Ani B, Hollenberg MD., Proc West Pharmacol Soc. January 1, 1997; 40 49-51.

Ligand cross-reactivity within the protease-activated receptor family., Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J, Scarborough RM., J Biol Chem. July 12, 1996; 271 (28): 16466-71.

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