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Summary Expression Phenotypes Gene Literature (37) GO Terms (4) Nucleotides (169) Proteins (43) Interactants (123) Wiki
XB-GENEPAGE-992186

Papers associated with clspn



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Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation., Hashimoto Y, Sadano K, Miyata N, Ito H, Tanaka H., EMBO J. September 4, 2023; 42 (17): e114131.                          

Translational Control of Xenopus Oocyte Meiosis: Toward the Genomic Era., Meneau F, Dupré A, Jessus C, Daldello EM., Cells. June 19, 2020; 9 (6):             

Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

Mitotic entry drives replisome disassembly at stalled replication forks., Hashimoto Y, Tanaka H., Biochem Biophys Res Commun. November 17, 2018; 506 (1): 108-113.      

APE2 promotes DNA damage response pathway from a single-strand break., Lin Y, Bai L, Cupello S, Hossain MA, Deem B, McLeod M, Raj J, Yan S., Nucleic Acids Res. March 16, 2018; 46 (5): 2479-2494.                

SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin., Ryu H, Yoshida MM, Sridharan V, Kumagai A, Dunphy WG, Dasso M, Azuma Y., Cell Cycle. January 1, 2015; 14 (17): 2777-84.

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress., Willis J, Patel Y, Lentz BL, Yan S., Proc Natl Acad Sci U S A. June 25, 2013; 110 (26): 10592-7.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks., Lee EM, Trinh TT, Shim HJ, Park SY, Nguyen TT, Kim MJ, Song YH., DNA Repair (Amst). September 1, 2012; 11 (9): 741-52.

The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1., Liu S, Song N, Zou L., Cell Cycle. July 15, 2012; 11 (14): 2711-6.

Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition., Gotoh T, Kishimoto T, Sible JC., Dev Biol. May 15, 2011; 353 (2): 302-8.          

Drf1-dependent kinase interacts with Claspin through a conserved protein motif., Gold DA, Dunphy WG., J Biol Chem. April 23, 2010; 285 (17): 12638-46.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase., Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A., J Biol Chem. November 27, 2009; 284 (48): 33107-14.

Plx1 is required for chromosomal DNA replication under stressful conditions., Trenz K, Errico A, Costanzo V., EMBO J. March 19, 2008; 27 (6): 876-85.              

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts., Errico A, Costanzo V, Hunt T., Proc Natl Acad Sci U S A. September 18, 2007; 104 (38): 14929-34.

Linking PCNA-dependent replication and ATR by human Claspin., Brondello JM, Ducommun B, Fernandez A, Lamb NJ., Biochem Biophys Res Commun. March 23, 2007; 354 (4): 1028-33.

Claspin: timing the cell cycle arrest when the genome is damaged., Freire R, van Vugt MA, Mamely I, Medema RH., Cell Cycle. December 1, 2006; 5 (24): 2831-4.

Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function., Chini CC, Chen J., J Biol Chem. November 3, 2006; 281 (44): 33276-82.

Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells., Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N., Cancer Res. September 1, 2006; 66 (17): 8672-9.

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling., Yan S, Lindsay HD, Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.          

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures., Yoo HY, Jeong SY, Dunphy WG., Genes Dev. April 1, 2006; 20 (7): 772-83.

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus., Lupardus PJ, Cimprich KA., Mol Biol Cell. April 1, 2006; 17 (4): 1559-69.

Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response., Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. November 1, 2005; 16 (11): 5269-82.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway., Clarke CA, Bennett LN, Clarke PR., J Biol Chem. October 21, 2005; 280 (42): 35337-45.

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system., Clarke CA, Clarke PR., Biochem J. June 1, 2005; 388 (Pt 2): 705-12.

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1., Kumagai A, Kim SM, Dunphy WG., J Biol Chem. November 26, 2004; 279 (48): 49599-608.

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures., Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A., J Biol Chem. September 17, 2004; 279 (38): 39289-95.

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases., Li W, Kim SM, Lee J, Lee J, Dunphy WG., J Cell Biol. June 21, 2004; 165 (6): 801-12.                

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. May 28, 2004; 117 (5): 575-88.

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation., Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.

Claspin, a regulator of Chk1 in DNA replication stress pathway., Chini CC, Chen J., DNA Repair (Amst). January 1, 2004; 3 (8-9): 1033-7.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation., Jeong SY, Kumagai A, Lee J, Lee J, Dunphy WG., J Biol Chem. November 21, 2003; 278 (47): 46782-8.

Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest., Yanow SK, Gold DA, Yoo HY, Dunphy WG., J Biol Chem. October 17, 2003; 278 (42): 41083-92.

Human claspin is required for replication checkpoint control., Chini CC, Chen J., J Biol Chem. August 8, 2003; 278 (32): 30057-62.

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17., Lee J, Lee J, Kumagai A, Dunphy WG., Mol Cell. February 1, 2003; 11 (2): 329-40.

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1., Kumagai A, Dunphy WG., Nat Cell Biol. February 1, 2003; 5 (2): 161-5.

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts., Kumagai A, Dunphy WG., Mol Cell. October 1, 2000; 6 (4): 839-49.

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