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Summary Expression Phenotypes Gene Literature (26) GO Terms (0) Nucleotides (61) Proteins (44) Interactants (137) Wiki
XB-GENEPAGE-993851

Papers associated with slc6a5



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The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters., Castagna M, Cinquetti R, Verri T, Vacca F, Giovanola M, Barca A, Romanazzi T, Roseti C, Galli A, Bossi E., Neurochem Res. January 1, 2022; 47 (1): 111-126.          

Modulation of Glycinergic Neurotransmission may Contribute to the Analgesic Effects of Propacetamol., Barsch L, Werdehausen R, Leffler A, Eulenburg V., Biomolecules. March 25, 2021; 11 (4):                             

A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors., Sheipouri D, Gallagher CI, Shimmon S, Rawling T, Vandenberg RJ., Biomolecules. November 30, 2020; 10 (12):                                                     

GlyT1 encephalopathy: Characterization of presumably disease causing GlyT1 mutations., Hauf K, Barsch L, Bauer D, Buchert R, Armbruster A, Frauenfeld L, Grasshoff U, Eulenburg V., Neurochem Int. October 1, 2020; 139 104813.

Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS., Kim E, Jeong I, Chung AY, Kim S, Kwon SH, Seong JY, Park HC., Sci Rep. March 22, 2019; 9 (1): 5025.              

Lipid-Based Inhibitors Act Directly on GlyT2., Schumann-Gillett A, O'Mara ML., ACS Chem Neurosci. March 20, 2019; 10 (3): 1668-1678.

Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2., Mostyn SN, Carland JE, Shimmon S, Ryan RM, Rawling T, Vandenberg RJ., ACS Chem Neurosci. September 20, 2017; 8 (9): 1949-1959.

Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2., Subramanian N, Scopelitti AJ, Carland JE, Ryan RM, O'Mara ML, Vandenberg RJ., PLoS One. January 1, 2016; 11 (6): e0157583.            

Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus., Thélie A, Desiderio S, Hanotel J, Quigley I, Van Driessche B, Rodari A, Borromeo MD, Kricha S, Lahaye F, Croce J, Cerda-Moya G, Ordoño Fernandez J, Bolle B, Lewis KE, Sander M, Pierani A, Schubert M, Johnson JE, Kintner CR, Pieler T, Van Lint C, Henningfeld KA, Bellefroid EJ, Van Campenhout C., Development. October 1, 2015; 142 (19): 3416-28.                                    

The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain., Werdehausen R, Mittnacht S, Bee LA, Minett MS, Armbruster A, Bauer I, Wood JN, Hermanns H, Eulenburg V., Pain. September 1, 2015; 156 (9): 1647-1659.                

Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β., Jiménez E, Núñez E, Ibáñez I, Zafra F, Aragón C, Giménez C., Neuropharmacology. February 1, 2015; 89 245-54.

Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain., Mingorance-Le Meur A, Ghisdal P, Mullier B, De Ron P, Downey P, Van Der Perren C, Declercq V, Cornelis S, Famelart M, Van Asperen J, Jnoff E, Courade JP., Br J Pharmacol. November 1, 2013; 170 (5): 1053-63.

Oleoyl-L-carnitine inhibits glycine transport by GlyT2., Carland JE, Mansfield RE, Ryan RM, Vandenberg RJ., Br J Pharmacol. February 1, 2013; 168 (4): 891-902.

Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease., Carta E, Chung SK, James VM, Robinson A, Gill JL, Remy N, Vanbellinghen JF, Drew CJ, Cagdas S, Cameron D, Cowan FM, Del Toro M, Graham GE, Manzur AY, Masri A, Rivera S, Scalais E, Shiang R, Sinclair K, Stuart CA, Tijssen MA, Wise G, Zuberi SM, Harvey K, Pearce BR, Topf M, Thomas RH, Supplisson S, Rees MI, Harvey RJ., J Biol Chem. August 17, 2012; 287 (34): 28975-85.

Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms., Lobikin M, Wang G, Xu J, Hsieh YW, Chuang CF, Lemire JM, Levin M., Proc Natl Acad Sci U S A. July 31, 2012; 109 (31): 12586-91.                    

Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord., Lall D, Armbruster A, Ruffert K, Betz H, Eulenburg V., Biochem Biophys Res Commun. July 13, 2012; 423 (4): 661-6.

An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling., Pérez-Siles G, Núñez E, Morreale A, Jiménez E, Leo-Macías A, Pita G, Cherubino F, Sangaletti R, Bossi E, Ortíz AR, Aragón C, López-Corcuera B., Biochem J. March 1, 2012; 442 (2): 323-34.

Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport., Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ., J Biol Chem. December 25, 2009; 284 (52): 36424-36430.

Expression patterns of glycine transporters (xGlyT1, xGlyT2, and xVIAAT) in Xenopus laevis during early development., Wester MR, Teasley DC, Byers SL, Saha MS., Gene Expr Patterns. April 1, 2008; 8 (4): 261-70.              

Molecular basis for substrate discrimination by glycine transporters., Vandenberg RJ, Shaddick K, Ju P., J Biol Chem. May 11, 2007; 282 (19): 14447-53.

Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease., Rees MI, Harvey K, Pearce BR, Chung SK, Duguid IC, Thomas P, Beatty S, Graham GE, Armstrong L, Shiang R, Abbott KJ, Zuberi SM, Stephenson JB, Owen MJ, Tijssen MA, van den Maagdenberg AM, Smart TG, Supplisson S, Harvey RJ., Nat Genet. July 1, 2006; 38 (7): 801-6.

The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS., Cui WW, Low SE, Hirata H, Saint-Amant L, Geisler R, Hume RI, Kuwada JY., J Neurosci. July 13, 2005; 25 (28): 6610-20.

Zn2+ inhibits glycine transport by glycine transporter subtype 1b., Ju P, Aubrey KR, Vandenberg RJ., J Biol Chem. May 28, 2004; 279 (22): 22983-91.

The glial and the neuronal glycine transporters differ in their reactivity to sulfhydryl reagents., Roux MJ, Martinez-Maza R, Le Goff A, Lopez-Corcuera B, Aragon C, Supplisson S., J Biol Chem. May 25, 2001; 276 (21): 17699-705.

Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes., Horiuchi M, Nicke A, Gomeza J, Aschrafi A, Schmalzing G, Betz H., Proc Natl Acad Sci U S A. February 13, 2001; 98 (4): 1448-53.

Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features., Liu QR, López-Corcuera B, Mandiyan S, Nelson H, Nelson N., J Biol Chem. October 25, 1993; 268 (30): 22802-8.

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