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Summary Expression Phenotypes Gene Literature (56) GO Terms (9) Nucleotides (108) Proteins (57) Interactants (99) Wiki
XB--1005168

Papers associated with slc1a2



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Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery., O'Connor EC, Kambara K, Bertrand D., Expert Opin Drug Discov. February 1, 2024; 19 (2): 173-187.      

Leucine 434 is essential for docosahexaenoic acid-induced augmentation of L-glutamate transporter current., Takahashi K, Chen L, Sayama M, Wu M, Hayashi MK, Irie T, Ohwada T, Sato K., J Biol Chem. January 1, 2023; 299 (1): 102793.        

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease., Iovino L, Giusti V, Pischedda F, Giusto E, Plotegher N, Marte A, Battisti I, Di Iacovo A, Marku A, Piccoli G, Bandopadhyay R, Perego C, Bonifacino T, Bonanno G, Roseti C, Bossi E, Arrigoni G, Bubacco L, Greggio E, Hilfiker S, Civiero L., Acta Neuropathol. July 1, 2022; 144 (1): 81-106.                    

Transport rate of EAAT2 is regulated by amino acid located at the interface between the scaffolding and substrate transport domains., Duffield M, Patel A, Mortensen OV, Schnur D, Gonzalez-Suarez AD, Torres-Salazar D, Fontana ACK., Neurochem Int. October 1, 2020; 139 104792.

Photoswitchable Inhibitor of a Glutamate Transporter., Cheng B, Shchepakin D, Kavanaugh MP, Trauner D., ACS Chem Neurosci. August 16, 2017; 8 (8): 1668-1672.

Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters., Niklaus S, Cadetti L, Vom Berg-Maurer CM, Lehnherr A, Hotz AL, Forster IC, Gesemann M, Neuhauss SCF., eNeuro. June 12, 2017; 4 (3):                   

Interaction of Excitatory Amino Acid Transporters 1 - 3 (EAAT1, EAAT2, EAAT3) with N-Carbamoylglutamate and N-Acetylglutamate., Burckhardt BC, Burckhardt G., Cell Physiol Biochem. January 1, 2017; 43 (5): 1907-1916.

Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4., Abousaab A, Warsi J, Elvira B, Lang F., J Membr Biol. June 1, 2016; 249 (3): 239-49.

Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors., Foster AC, Li YX, Runyan S, Dinh T, Venadas S, Chen J, Pashikanti S, Datta A, Ehring G, Staubli U., J Neurochem. February 1, 2016; 136 (4): 692-697.

Up-Regulation of the Excitatory Amino Acid Transporters EAAT1 and EAAT2 by Mammalian Target of Rapamycin., Abousaab A, Uzcategui NL, Elsir B, Lang F., Cell Physiol Biochem. January 1, 2016; 39 (6): 2492-2500.

The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2., Simonin A, Montalbetti N, Gyimesi G, Pujol-Giménez J, Hediger MA., J Biol Chem. December 18, 2015; 290 (51): 30464-74.

Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1., Abousaab A, Warsi J, Elvira B, Alesutan I, Hoseinzadeh Z, Lang F., J Membr Biol. December 1, 2015; 248 (6): 1107-19.

Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho., Warsi J, Abousaab A, Lang F., Neurosignals. January 1, 2015; 23 (1): 59-70.

Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3β., Jiménez E, Núñez E, Ibáñez I, Draffin JE, Zafra F, Giménez C., Neurochem Int. December 1, 2014; 79 33-43.

Upregulation of excitatory amino acid transporters by coexpression of Janus kinase 3., Warsi J, Luo D, Elvira B, Jilani K, Shumilina E, Hosseinzadeh Z, Lang F., J Membr Biol. August 1, 2014; 247 (8): 713-20.

Cysteine transport through excitatory amino acid transporter 3 (EAAT3)., Watts SD, Torres-Salazar D, Divito CB, Amara SG., PLoS One. January 1, 2014; 9 (10): e109245.            

Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation., García-Tardón N, González-González IM, Martínez-Villarreal J, Fernández-Sánchez E, Giménez C, Zafra F., J Biol Chem. June 1, 2012; 287 (23): 19177-87.

A large scale screen for neural stem cell markers in Xenopus retina., Parain K, Mazurier N, Bronchain O, Borday C, Cabochette P, Chesneau A, Colozza G, El Yakoubi W, Hamdache J, Locker M, Gilchrist MJ, Pollet N, Perron M., Dev Neurobiol. April 1, 2012; 72 (4): 491-506.                                                    

Elevated ammonium levels: differential acute effects on three glutamate transporter isoforms., Søgaard R, Novak I, MacAulay N., Am J Physiol Cell Physiol. March 15, 2012; 302 (6): C880-91.

The central cavity in trimeric glutamate transporters restricts ligand diffusion., Leary GP, Holley DC, Stone EF, Lyda BR, Kalachev LV, Kavanaugh MP., Proc Natl Acad Sci U S A. September 6, 2011; 108 (36): 14980-5.

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease., Scott HA, Gebhardt FM, Mitrovic AD, Vandenberg RJ, Dodd PR., Neurobiol Aging. March 1, 2011; 32 (3): 553.e1-11.

Hetero-oligomerization of neuronal glutamate transporters., Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C., J Biol Chem. February 4, 2011; 286 (5): 3935-43.

Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse., Sun W, Hoffman KM, Holley DC, Kavanaugh MP., PLoS One. January 1, 2011; 6 (8): e23765.          

Regulation of the glutamate transporters by JAK2., Hosseinzadeh Z, Bhavsar SK, Sopjani M, Alesutan I, Saxena A, Dërmaku-Sopjani M, Lang F., Cell Physiol Biochem. January 1, 2011; 28 (4): 693-702.

Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB)., Luethi E, Nguyen KT, Bürzle M, Blum LC, Suzuki Y, Hediger M, Reymond JL., J Med Chem. October 14, 2010; 53 (19): 7236-50.

Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids., Habjan S, Vandenberg RJ., Neurochem Res. October 1, 2009; 34 (10): 1738-47.

The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters., Teichman S, Qu S, Kanner BI., Proc Natl Acad Sci U S A. August 25, 2009; 106 (34): 14297-302.

The role of cation binding in determining substrate selectivity of glutamate transporters., Huang S, Ryan RM, Vandenberg RJ., J Biol Chem. February 13, 2009; 284 (7): 4510-5.

Regulation of the glutamate transporter EAAT2 by PIKfyve., Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F., Cell Physiol Biochem. January 1, 2009; 24 (5-6): 361-8.

Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance., Torres-Salazar D, Fahlke C., J Biol Chem. November 30, 2007; 282 (48): 34719-26.

Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases., Boehmer C, Palmada M, Rajamanickam J, Schniepp R, Amara S, Lang F., J Neurochem. May 1, 2006; 97 (4): 911-21.

The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3., Esslinger CS, Agarwal S, Gerdes J, Wilson PA, Davis ES, Awes AN, O'Brien E, Mavencamp T, Koch HP, Poulsen DJ, Rhoderick JF, Chamberlin AR, Kavanaugh MP, Bridges RJ., Neuropharmacology. November 1, 2005; 49 (6): 850-61.

Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2., Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J., Mol Pharmacol. October 1, 2005; 68 (4): 974-82.

Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics., Matute C, Melone M, Vallejo-Illarramendi A, Conti F., Glia. February 1, 2005; 49 (3): 451-5.

WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake., Dunlop J, Eliasof S, Stack G, McIlvain HB, Greenfield A, Kowal D, Petroski R, Carrick T., Br J Pharmacol. November 1, 2003; 140 (5): 839-46.

Effects of local and intravenous anesthetics on the activity of glutamate transporter type 2., Lim YJ, Huang Y, Fang H, Zuo Z., Brain Res Bull. September 30, 2003; 61 (5): 537-40.

The different responses of rat glutamate transporter type 2 and its mutant (tyrosine 403 to histidine) activity to volatile anesthetics and activation of protein kinase C., Fang H, Huang Y, Zuo Z., Brain Res. October 25, 2002; 953 (1-2): 255-64.

Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)., Shigeri Y, Shimamoto K, Yasuda-Kamatani Y, Seal RP, Yumoto N, Nakajima T, Amara SG., J Neurochem. October 1, 2001; 79 (2): 297-302.

Cloning and characterization of excitatory amino acid transporters GLT-1 and EAAC1 in canine brain., Sato K, Inaba M, Baba K, Tamahara S, Koshino I, Hikasa Y, Ono K, Kagota K., J Vet Med Sci. September 1, 2001; 63 (9): 997-1002.

The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine., Melone M, Vitellaro-Zuccarello L, Vallejo-Illarramendi A, Pérez-Samartin A, Matute C, Cozzi A, Pellegrini-Giampietro DE, Rothstein JD, Conti F., Mol Psychiatry. July 1, 2001; 6 (4): 380-6.

Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems., Eliasof S, McIlvain HB, Petroski RE, Foster AC, Dunlop J., J Neurochem. April 1, 2001; 77 (2): 550-7.

Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters., Koch HP, Kavanaugh MP, Esslinger CS, Zerangue N, Humphrey JM, Amara SG, Chamberlin AR, Bridges RJ., Mol Pharmacol. December 1, 1999; 56 (6): 1095-104.

Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions., Vandenberg RJ, Mitrovic AD, Johnston GA., Mol Pharmacol. July 1, 1998; 54 (1): 189-96.

Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2., Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ., J Biol Chem. June 12, 1998; 273 (24): 14698-706.

Localization and function of five glutamate transporters cloned from the salamander retina., Eliasof S, Arriza JL, Leighton BH, Amara SG, Kavanaugh MP., Vision Res. May 1, 1998; 38 (10): 1443-54.

Serine-O-sulphate transport by the human glutamate transporter, EAAT2., Vandenberg RJ, Mitrovic AD, Johnston GA., Br J Pharmacol. April 1, 1998; 123 (8): 1593-600.

DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters., Shimamoto K, Lebrun B, Yasuda-Kamatani Y, Sakaitani M, Shigeri Y, Yumoto N, Nakajima T., Mol Pharmacol. February 1, 1998; 53 (2): 195-201.

Tissue specific variants of glutamate transporter GLT-1., Utsunomiya-Tate N, Endou H, Kanai Y., FEBS Lett. October 27, 1997; 416 (3): 312-6.

New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter., Lebrun B, Sakaitani M, Shimamoto K, Yasuda-Kamatani Y, Nakajima T., J Biol Chem. August 15, 1997; 272 (33): 20336-9.

Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2., Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GA., Mol Pharmacol. May 1, 1997; 51 (5): 809-15.

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