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Summary Expression Phenotypes Gene Literature (48) GO Terms (0) Nucleotides (51) Proteins (30) Interactants (20) Wiki

Papers associated with grin2d

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Subunit-specific effects of poricoic acid A on NMDA receptors., Lee J, Kim C, Yeom HD, Nguyen KVA, Eom S, Lee S, Jung JH, Lee JH, Kim SH, Kim IK, Lee JH, Lee JH., Pharmacol Rep. April 1, 2020; 72 (2): 472-480.

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups., Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF., Elife. January 1, 2018; 7                                                                         

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity., Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF., Mol Pharmacol. December 1, 2016; 90 (6): 689-702.

From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes., Platt RJ, Curtice KJ, Twede VD, Watkins M, Gruszczyński P, Bulaj G, Horvath MP, Olivera BM., Toxicon. April 1, 2014; 81 67-79.

The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism., Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH., Mol Pharmacol. August 1, 2013; 84 (2): 261-74.

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons., Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH., J Neurochem. November 1, 2011; 119 (3): 486-96.

Characterization of conantokin Rl-A: molecular phylogeny as structure/function study., Gowd KH, Watkins M, Twede VD, Bulaj GW, Olivera BM., J Pept Sci. August 1, 2010; 16 (8): 375-82.

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists., Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, Murphy TJ, Snyder JP, Bräuner-Osborne H, Traynelis SF., J Pharmacol Exp Ther. June 1, 2010; 333 (3): 650-62.

N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse., Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, Lozovaya NA, Jane DE, Monaghan DT., J Pharmacol Exp Ther. November 1, 2009; 331 (2): 618-26.

Control of NMDA receptor function by the NR2 subunit amino-terminal domain., Yuan H, Hansen KB, Vance KM, Ogden KK, Traynelis SF., J Neurosci. September 30, 2009; 29 (39): 12045-58.

Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor., Twede VD, Teichert RW, Walker CS, Gruszczyński P, Kaźmierkiewicz R, Bulaj G, Olivera BM., Biochemistry. May 19, 2009; 48 (19): 4063-73.

Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors., Sivaprakasam M, Hansen KB, David O, Nielsen B, Traynelis SF, Clausen RP, Couty F, Bunch L., ChemMedChem. January 1, 2009; 4 (1): 110-7.

Differential effects of linear and cyclic polyamines on NMDA receptor activities., Masuko T, Miyake M, Kusama-Eguchi K, Koike T, Kimura E, Kizawa Y, Kashiwagi K, Igarashi K, Kusama T., Neurochem Int. July 1, 2008; 53 (1-2): 38-44.

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes., Wrighton DC, Baker EJ, Chen PE, Wyllie DJ., J Physiol. January 1, 2008; 586 (1): 211-25.

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes., Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ., J Physiol. January 1, 2008; 586 (1): 227-45.

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors., Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF., Mol Pharmacol. October 1, 2007; 72 (4): 907-20.

Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block., Dravid SM, Erreger K, Yuan H, Nicholson K, Le P, Lyuboslavsky P, Almonte A, Murray E, Mosely C, Barber J, French A, Balster R, Murray TF, Traynelis SF., J Physiol. May 15, 2007; 581 (Pt 1): 107-28.

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids., Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C., J Med Chem. October 6, 2005; 48 (20): 6315-25.

Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket., Kinarsky L, Feng B, Skifter DA, Morley RM, Sherman S, Jane DE, Monaghan DT., J Pharmacol Exp Ther. June 1, 2005; 313 (3): 1066-74.

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists., Morley RM, Tse HW, Feng B, Miller JC, Monaghan DT, Jane DE., J Med Chem. April 7, 2005; 48 (7): 2627-37.

The effect of competitive antagonist chain length on NMDA receptor subunit selectivity., Feng B, Morley RM, Jane DE, Monaghan DT., Neuropharmacology. March 1, 2005; 48 (3): 354-9.

The micromolar zinc-binding domain on the NMDA receptor subunit NR2B., Rachline J, Perin-Dureau F, Le Goff A, Neyton J, Paoletti P., J Neurosci. January 12, 2005; 25 (2): 308-17.

Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ''superslow'' afterburst EPSC in rat hippocampus., Lozovaya NA, Grebenyuk SE, Tsintsadze TSh, Feng B, Monaghan DT, Krishtal OA., J Physiol. July 15, 2004; 558 (Pt 2): 451-63.

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors., Chen PE, Johnston AR, Mok MH, Schoepfer R, Wyllie DJ., J Physiol. July 1, 2004; 558 (Pt 1): 45-58.

Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid., Feng B, Tse HW, Skifter DA, Morley R, Jane DE, Monaghan DT., Br J Pharmacol. February 1, 2004; 141 (3): 508-16.

Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons., Bickler PE, Fahlman CS, Taylor DM., Neuroscience. January 1, 2003; 118 (1): 25-35.

N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors., Grimwood S, Wafford KA, Macaulay A, Hutson PH., J Neurochem. August 1, 2002; 82 (4): 794-800.

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids., Malayev A, Gibbs TT, Farb DH., Br J Pharmacol. February 1, 2002; 135 (4): 901-9.

Single channel analysis of a novel NMDA channel from Xenopus oocytes expressing recombinant NR1a, NR2A and NR2D subunits., Cheffings CM, Colquhoun D., J Physiol. August 1, 2000; 526 Pt 3 481-91.

In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus., White HS, McCabe RT, Armstrong H, Donevan SD, Cruz LJ, Abogadie FC, Torres J, Rivier JE, Paarmann I, Hollmann M, Olivera BM., J Pharmacol Exp Ther. January 1, 2000; 292 (1): 425-32.

Stimulatory and inhibitory properties of aminoglycoside antibiotics at N-methyl-D-aspartate receptors., Masuko T, Kuno T, Kashiwagi K, Kusama T, Williams K, Igarashi K., J Pharmacol Exp Ther. September 1, 1999; 290 (3): 1026-33.

NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A., Goebel DJ, Poosch MS., Brain Res Mol Brain Res. June 8, 1999; 69 (2): 164-70.

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit., Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL., J Neurosci. August 15, 1998; 18 (16): 6163-75.

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors., Wyllie DJ, Béhé P, Colquhoun D., J Physiol. July 1, 1998; 510 ( Pt 1) 1-18.

Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors., Hess SD, Daggett LP, Deal C, Lu CC, Johnson EC, Veliçelebi G., J Neurochem. March 1, 1998; 70 (3): 1269-79.

Benzyl-polyamines: novel, potent N-methyl-D-aspartate receptor antagonists., Igarashi K, Shirahata A, Pahk AJ, Kashiwagi K, Williams K., J Pharmacol Exp Ther. November 1, 1997; 283 (2): 533-40.

Lead inhibition of N-methyl-D-aspartate receptors containing NR2A, NR2C and NR2D subunits., Omelchenko IA, Nelson CS, Allen CN., J Pharmacol Exp Ther. September 1, 1997; 282 (3): 1458-64.

Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes., Buller AL, Monaghan DT., Eur J Pharmacol. February 5, 1997; 320 (1): 87-94.

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol., Ilyin VI, Whittemore ER, Guastella J, Weber E, Woodward RM., Mol Pharmacol. December 1, 1996; 50 (6): 1541-50.

Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes., Wyllie DJ, Béhé P, Nassar M, Schoepfer R, Colquhoun D., Proc Biol Sci. August 22, 1996; 263 (1373): 1079-86.

Multiple structural elements determine subunit specificity of Mg2+ block in NMDA receptor channels., Kuner T, Schoepfer R., J Neurosci. June 1, 1996; 16 (11): 3549-58.

Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes., Buller AL, Larson HC, Morrisett RA, Monaghan DT., Mol Pharmacol. October 1, 1995; 48 (4): 717-23.

Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators., Chu B, Anantharam V, Treistman SN., J Neurochem. July 1, 1995; 65 (1): 140-8.

Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit., Williams K., Neurosci Lett. January 30, 1995; 184 (3): 181-4.

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor., Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA., Neuron. October 1, 1994; 13 (4): 929-36.

The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition., Buller AL, Larson HC, Schneider BE, Beaton JA, Morrisett RA, Monaghan DT., J Neurosci. September 1, 1994; 14 (9): 5471-84.

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits., Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M., J Biol Chem. February 5, 1993; 268 (4): 2836-43.

Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor., Sakurada K, Masu M, Nakanishi S., J Biol Chem. January 5, 1993; 268 (1): 410-5.

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