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Summary Expression Phenotypes Gene Literature (103) GO Terms (6) Nucleotides (101) Proteins (74) Interactants (240) Wiki
XB--478442

Papers associated with nedd4



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Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l., Kim HS, Green YS, Xie Y, Christian JL., Proc Natl Acad Sci U S A. September 7, 2021; 118 (36):                       

Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway., Wang H, Wang C, Wang C, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H., Development. May 15, 2021; 148 (10):                                           

The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease., Manning JA, Shah SS, Nikolic A, Henshall TL, Khew-Goodall Y, Kumar S, Kumar S., Cell Death Dis. April 14, 2021; 12 (4): 398.

Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis., Ilyaskin AV, Korbmacher C, Diakov A., J Biol Chem. January 1, 2021; 296 100404.                                

Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations., Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T., Front Mol Neurosci. January 1, 2021; 14 798261.

RINGO/Speedy proteins, a family of non-canonical activators of CDK1 and CDK2., Gonzalez L, Nebreda AR., Semin Cell Dev Biol. November 1, 2020; 107 21-27.  

Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis., Lokapally A, Neuhaus H, Herfurth J, Hollemann T., Cells. July 20, 2020; 9 (7):                                           

β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells., Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR., J Biol Chem. July 20, 2018; 293 (29): 11612-11624.

The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2., Krueger B, Yang L, Korbmacher C, Rauh R., Pflugers Arch. April 1, 2018; 470 (4): 649-660.

Regulation of Kv1.4 potassium channels by PKC and AMPK kinases., Andersen MN, Skibsbye L, Saljic A, Larsen MZ, Rasmussen HB, Jespersen T., Channels (Austin). January 1, 2018; 12 (1): 34-44.              

The Nedd4 binding protein 3 is required for anterior neural development in Xenopus laevis., Kiem LM, Dietmann P, Linnemann A, Schmeisser MJ, Kühl SJ., Dev Biol. March 1, 2017; 423 (1): 66-76.                            

SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5)., Ahmed M, Fezai M, Uzcategui NL, Hosseinzadeh Z, Lang F., Cell Physiol Biochem. January 1, 2016; 38 (1): 359-67.

Up-regulation of epithelial Na(+) channel ENaC by human parvovirus B19 capsid protein VP1., Ahmed M, Honisch S, Pelzl L, Fezai M, Hosseinzadeh Z, Bock CT, Kandolf R, Lang F., Biochem Biophys Res Commun. December 4, 2015; 468 (1-2): 179-84.

USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2., Warsi J, Hosseinzadeh Z, Elvira B, Pelzl L, Shumilina E, Zhang DE, Lang KS, Lang PA, Lang F., PLoS One. June 5, 2015; 10 (6): e0129365.            

PKC and AMPK regulation of Kv1.5 potassium channels., Andersen MN, Skibsbye L, Tang C, Petersen F, MacAulay N, Rasmussen HB, Jespersen T., Channels (Austin). January 1, 2015; 9 (3): 121-8.

NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling., Zhang Y, Ding Y, Chen YG, Chen YG, Tao Q, Tao Q., Dev Biol. August 1, 2014; 392 (1): 15-25.                              

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter., Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G., Am J Physiol Renal Physiol. August 1, 2014; 307 (3): F275-86.

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels., Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA., FASEB J. May 1, 2014; 28 (5): 2177-90.

Down-regulation of the epithelial Na⁺ channel ENaC by Janus kinase 2., Hosseinzadeh Z, Luo D, Sopjani M, Bhavsar SK, Lang F., J Membr Biol. April 1, 2014; 247 (4): 331-8.

Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons., Ekberg JA, Boase NA, Rychkov G, Manning J, Poronnik P, Kumar S, Kumar S., Biochem J. January 1, 2014; 457 (1): 27-31.

AMP-activated protein kinase regulates hERG potassium channel., Almilaji A, Munoz C, Elvira B, Fajol A, Pakladok T, Honisch S, Shumilina E, Lang F, Föller M., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.

Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8., L Y K, McIntosh CJ, Biasio W, Liu Y, Ke Y, Olson DR, Miller JH, Page R, Snyder PM, McDonald FJ., J Cell Physiol. November 1, 2013; 228 (11): 2190-201.

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D., Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT., Neuropharmacology. November 1, 2013; 74 96-107.

The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons., Schmeisser MJ, Kühl SJ, Schoen M, Beth NH, Weis TM, Grabrucker AM, Kühl M, Boeckers TM., Neural Dev. September 17, 2013; 8 18.                    

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination., Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC., Am J Physiol Renal Physiol. July 1, 2013; 305 (1): F31-41.

Nedd4-2 does not regulate wt-CFTR in human airway epithelial cells., Koeppen K, Chapline C, Sato JD, Stanton BA., Am J Physiol Lung Cell Mol Physiol. October 15, 2012; 303 (8): L720-7.

Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN., Christie KJ, Martinez JA, Zochodne DW., Mol Cell Neurosci. June 1, 2012; 50 (2): 179-92.

Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation., García-Tardón N, González-González IM, Martínez-Villarreal J, Fernández-Sánchez E, Giménez C, Zafra F., J Biol Chem. June 1, 2012; 287 (23): 19177-87.

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels., Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen SP, Abriel H, Jespersen T., Heart Rhythm. March 1, 2012; 9 (3): 440-8.

Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors., Pei J, Grishin NV., Cell Signal. March 1, 2012; 24 (3): 758-69.

AMP-activated protein kinase downregulates Kv7.1 cell surface expression., Andersen MN, Krzystanek K, Jespersen T, Olesen SP, Rasmussen HB., Traffic. January 1, 2012; 13 (1): 143-56.

Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase., Kalinichenko SV, Itoh K, Korobko EV, Sokol SY, Buchman VL, Korobko IV., PLoS One. January 1, 2012; 7 (6): e39505.              

Downregulation of Kv1.5 K channels by the AMP-activated protein kinase., Mia S, Munoz C, Pakladok T, Siraskar G, Voelkl J, Alesutan I, Lang F., Cell Physiol Biochem. January 1, 2012; 30 (4): 1039-50.

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway., Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O., J Am Soc Nephrol. September 1, 2011; 22 (9): 1707-19.

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2., Oberfeld B, Ruffieux-Daidié D, Vitagliano JJ, Pos KM, Verrey F, Staub O., Am J Physiol Renal Physiol. July 1, 2011; 301 (1): F189-96.

Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase., Alesutan I, Munoz C, Sopjani M, Dërmaku-Sopjani M, Michael D, Fraser S, Kemp BE, Seebohm G, Föller M, Lang F., Biochem Biophys Res Commun. May 20, 2011; 408 (4): 505-10.

Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase., Alesutan I, Föller M, Sopjani M, Dërmaku-Sopjani M, Zelenak C, Fröhlich H, Velic A, Fraser S, Kemp BE, Seebohm G, Völkl H, Lang F., Mol Membr Biol. February 1, 2011; 28 (2): 79-89.

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells., Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR., Am J Physiol Renal Physiol. December 1, 2010; 299 (6): F1308-19.

Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2., Zhang W, Na T, Wu G, Jing H, Peng JB., J Biol Chem. November 19, 2010; 285 (47): 36586-96.

Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel., Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D., J Biol Chem. July 9, 2010; 285 (28): 21671-8.

COMMD1 downregulates the epithelial sodium channel through Nedd4-2., Ke Y, Butt AG, Swart M, Liu YF, McDonald FJ., Am J Physiol Renal Physiol. June 1, 2010; 298 (6): F1445-56.

E3 ligase Nedd4 promotes axon branching by downregulating PTEN., Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE., Neuron. February 11, 2010; 65 (3): 341-57.                  

Protein kinase B alpha (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms., Diakov A, Nesterov V, Mokrushina M, Rauh R, Korbmacher C., Cell Physiol Biochem. January 1, 2010; 26 (6): 913-24.

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species., Lazrak A, Iles KE, Liu G, Noah DL, Noah JW, Matalon S., FASEB J. November 1, 2009; 23 (11): 3829-42.

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2., Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR., J Biol Chem. January 2, 2009; 284 (1): 150-157.

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain., Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D., Biochem J. October 1, 2008; 415 (1): 155-63.

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1., Schuetz F, Kumar S, Poronnik P, Adams DJ., Am J Physiol Cell Physiol. July 1, 2008; 295 (1): C73-80.

Regulation of the epithelial Na+ channel by the protein kinase CK2., Bachhuber T, Almaça J, Aldehni F, Mehta A, Amaral MD, Schreiber R, Kunzelmann K., J Biol Chem. May 9, 2008; 283 (19): 13225-32.                

A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus., Jean S, Moss T., Differentiation. April 1, 2008; 76 (4): 431-41.                  

Up-regulation of hypertonicity-activated myo-inositol transporter SMIT1 by the cell volume-sensitive protein kinase SGK1., Klaus F, Palmada M, Lindner R, Laufer J, Jeyaraj S, Lang F, Boehmer C., J Physiol. March 15, 2008; 586 (6): 1539-47.

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