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Summary Expression Phenotypes Gene Literature (154) GO Terms (9) Nucleotides (134) Proteins (60) Interactants (487) Wiki
XB--491845

Papers associated with chek1



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Mebendazole preferentially inhibits cilia formation and exerts anticancer activity by synergistically augmenting DNA damage., Hong J, Kwon KY, Jang DG, Kwon T, Yoon H, Park TJ., Biomed Pharmacother. March 20, 2024; 174 116434.                              

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response., Lin Y, Li J, Zhao H, McMahon A, McGhee K, Yan S., Elife. May 22, 2023; 12


The cohesin modifier ESCO2 is stable during DNA replication., Jevitt AM, Rankin BD, Chen J, Rankin S., Chromosome Res. January 28, 2023; 31 (1): 6.        

Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis., Chen H, Good MC., Curr Biol. October 10, 2022; 32 (19): 4314-4324.e7.                        

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks., Montales K, Ruis K, Lindsay H, Michael WM., PLoS One. August 2, 2022; 17 (8): e0271905.                

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase., Tarcan Z, Poovathumkadavil D, Skagia A, Gambus A., J Biol Chem. August 1, 2022; 298 (8): 102234.                          

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks., Ruis K, Huynh O, Montales K, Barr NA, Michael WM., J Biol Chem. July 1, 2022; 298 (7): 101992.            

Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability., Chaudhari S, Ware AP, Jayaram P, Gorthi SP, El-Khamisy SF, Satyamoorthy K., Biochimie. November 1, 2021; 190 70-90.

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus., Ciardo D, Haccard O, Narassimprakash H, Cornu D, Guerrera IC, Goldar A, Marheineke K., Nucleic Acids Res. September 27, 2021; 49 (17): 9851-9869.                                        

Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint., Ciardo D, Haccard O, Narassimprakash H, Arbona JM, Hyrien O, Audit B, Marheineke K, Goldar A., Genes (Basel). August 9, 2021; 12 (8):               

Cell cycle control during early embryogenesis., Brantley SE, Di Talia S., Development. July 1, 2021; 148 (13):


Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis., Wu HY, Zhou YM, Liao ZQ, Zhong JW, Liu YB, Zhao H, Liang CQ, Huang RJ, Park KS, Feng SS, Zheng L, Cai DQ, Qi XF., NPJ Regen Med. June 29, 2021; 6 (1): 36.                    

Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system., Montales K, Kim A, Ruis K, Michael WM., Sci Rep. January 11, 2021; 11 (1): 467.                

Ongoing replication forks delay the nuclear envelope breakdown upon mitotic entry., Hashimoto Y, Tanaka H., J Biol Chem. January 1, 2021; 296 100033.                

Function and molecular mechanisms of APE2 in genome and epigenome integrity., Lin Y, McMahon A, Driscoll G, Bullock S, Zhao J, Yan S., Mutat Res Rev Mutat Res. January 1, 2021; 787 108347.

Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system., Ciardo D, Haccard O, Narassimprakash H, Chiodelli V, Goldar A, Marheineke K., Cell Cycle. July 1, 2020; 19 (14): 1817-1832.

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair., Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok BH, Peng A., Elife. January 17, 2020; 9                                                         

Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts., Cupello S, Lin Y, Yan S., Biochem J. December 23, 2019; 476 (24): 3791-3804.                

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress., Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C., Elife. September 30, 2019; 8                                     

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements., Deng L, Wu RA, Sonneville R, Kochenova OV, Labib K, Pellman D, Walter JC., Mol Cell. March 7, 2019; 73 (5): 915-929.e6.                              

TRAIP is a master regulator of DNA interstrand crosslink repair., Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC., Nature. March 1, 2019; 567 (7747): 267-272.                          

Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

Methods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg Extracts., Lin Y, Ha A, Yan S., Methods Mol Biol. January 1, 2019; 1999 161-172.

Mitotic entry drives replisome disassembly at stalled replication forks., Hashimoto Y, Tanaka H., Biochem Biophys Res Commun. November 17, 2018; 506 (1): 108-113.      

APE2 promotes DNA damage response pathway from a single-strand break., Lin Y, Bai L, Cupello S, Hossain MA, Deem B, McLeod M, Raj J, Yan S., Nucleic Acids Res. March 16, 2018; 46 (5): 2479-2494.                

Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress., Wang F, Zhu S, Fisher LA, Wang W, Oakley GG, Li C, Peng A., Sci Rep. February 8, 2018; 8 (1): 2683.            

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining., Zhu S, Fisher LA, Bessho T, Peng A., Nucleic Acids Res. October 13, 2017; 45 (18): 10583-10594.            

Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts., Holden J, Taylor EM, Lindsay HD., PLoS One. July 10, 2017; 12 (7): e0181131.            

An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism., Hodroj D, Recolin B, Serhal K, Martinez S, Tsanov N, Abou Merhi R, Maiorano D., EMBO J. May 2, 2017; 36 (9): 1182-1198.

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1., Alver RC, Chadha GS, Gillespie PJ, Blow JJ., Cell Rep. March 7, 2017; 18 (10): 2508-2520.                

Regulation of DNA Replication in Early Embryonic Cleavages., Kermi C, Lo Furno E, Maiorano D., Genes (Basel). January 19, 2017; 8 (1):           

High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration., Owens DA, Butler AM, Aguero TH, Newman KM, Van Booven D, King ML., Development. January 15, 2017; 144 (2): 292-304.                                                                                        

APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress., Wallace BD, Berman Z, Mueller GA, Lin Y, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S, Williams RS., Proc Natl Acad Sci U S A. January 10, 2017; 114 (2): 304-309.

Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication., Raspelli E, Falbo L, Costanzo V., Genesis. January 1, 2017; 55 (1-2):       

Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes., Johnson JR, Santos SD, Johnson T, Pieper U, Strumillo M, Wagih O, Sali A, Krogan NJ, Beltrao P., PLoS Comput Biol. August 27, 2015; 11 (8): e1004362.                            

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos., Kermi C, Prieto S, van der Laan S, Tsanov N, Recolin B, Uro-Coste E, Delisle MB, Maiorano D., Dev Cell. August 10, 2015; 34 (3): 364-72.        

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus., Platel M, Goldar A, Wiggins JM, Barbosa P, Libeau P, Priam P, Narassimprakash H, Grodzenski X, Marheineke K., PLoS One. June 5, 2015; 10 (6): e0129090.                    

REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts., DeStephanis D, McLeod M, Yan S., Biochem Biophys Res Commun. May 8, 2015; 460 (3): 609-15.

Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication., Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG., Mol Cell. February 5, 2015; 57 (3): 492-505.

Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts., Bai L, Michael WM, Yan S., Cell Signal. May 1, 2014; 26 (5): 857-67.

PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication., Bianchi J, Rudd SG, Jozwiakowski SK, Bailey LJ, Soura V, Taylor E, Stevanovic I, Green AJ, Stracker TH, Lindsay HD, Doherty AJ., Mol Cell. November 21, 2013; 52 (4): 566-73.          

Titration of four replication factors is essential for the Xenopus laevis midblastula transition., Collart C, Allen GE, Bradshaw CR, Smith JC, Zegerman P., Science. August 23, 2013; 341 (6148): 893-6.

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation., Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS., EMBO J. July 31, 2013; 32 (15): 2172-85.                

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress., Willis J, Patel Y, Lentz BL, Yan S., Proc Natl Acad Sci U S A. June 25, 2013; 110 (26): 10592-7.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

A role for the MRN complex in ATR activation via TOPBP1 recruitment., Duursma AM, Driscoll R, Elias JE, Cimprich KA., Mol Cell. April 11, 2013; 50 (1): 116-22.

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling., Yan S, Willis J., Biochem Biophys Res Commun. February 15, 2013; 431 (3): 466-71.

Study of the DNA damage checkpoint using Xenopus egg extracts., Willis J, DeStephanis D, Patel Y, Gowda V, Yan S., J Vis Exp. November 5, 2012; (69): e4449.

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network., Karanja KK, Cox SW, Duxin JP, Stewart SA, Campbell JL., Cell Cycle. November 1, 2012; 11 (21): 3983-96.              

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