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Summary Expression Phenotypes Gene Literature (217) GO Terms (9) Nucleotides (125) Proteins (57) Interactants (1373) Wiki
XB--5964398

Papers associated with nodal3.1



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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling., Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E., Nat Commun. October 5, 2023; 14 (1): 6173.                                

Mink1 regulates spemann organizer cell fate in the xenopus gastrula via Hmga2., Colleluori V, Khokha MK., Dev Biol. March 1, 2023; 495 42-53.                            

maea affects head formation through ß-catenin degradation during early Xenopus laevis development., Goto T, Shibuya H., Dev Growth Differ. January 1, 2023; 65 (1): 29-36.                  

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR., Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK., Nat Commun. November 5, 2022; 13 (1): 6681.                                            

Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants., Houston DW, Elliott KL, Coppenrath K, Wlizla M, Horb ME., Development. September 1, 2022; 149 (17):                                   

ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis., Goto T, Michiue T, Shibuya H., Dev Growth Differ. June 1, 2022; 64 (5): 254-260.        

Lysosomes are required for early dorsal signaling in the Xenopus embryo., Tejeda-Muñoz N, De Robertis EM., Proc Natl Acad Sci U S A. April 26, 2022; 119 (17): e2201008119.                          

Rab7 is required for mesoderm patterning and gastrulation in Xenopus., Kreis J, Wielath FM, Vick P., Biol Open. July 15, 2021; 10 (7):                                           

Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway., Wang H, Wang C, Wang C, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H., Development. May 15, 2021; 148 (10):                                           

Geoffroea decorticans fruit extracts inhibit the wnt/β-catenin pathway, a therapeutic target in cancer., Somaini GC, Aybar MJ, Vera NR, Tríbulo C., Biochem Biophys Res Commun. March 26, 2021; 546 118-123.          

Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis., Huang X, Zhang L, Yang S, Zhang Y, Wu M, Chen P., Genes (Basel). November 18, 2020; 11 (11):                   

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis., Chen M, Amado N, Tan J, Reis A, Ge M, Abreu JG, He X., Elife. September 14, 2020; 9                                                                                           

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network., Mukherjee S, Chaturvedi P, Rankin SA, Rankin SA, Fish MB, Wlizla M, Paraiso KD, MacDonald M, Chen X, Weirauch MT, Blitz IL, Cho KW, Zorn AM., Elife. September 7, 2020; 9                           

Natural size variation among embryos leads to the corresponding scaling in gene expression., Leibovich A, Edri T, Klein SL, Moody SA, Fainsod A., Dev Biol. June 15, 2020; 462 (2): 165-179.                    

Chromatin accessibility and histone acetylation in the regulation of competence in early development., Esmaeili M, Blythe SA, Tobias JW, Zhang K, Yang J, Klein PS., Dev Biol. June 1, 2020; 462 (1): 20-35.                

The secreted BMP antagonist ERFE is required for the development of a functional circulatory system in Xenopus., Melchert J, Henningfeld KA, Richts S, Lingner T, Jonigk D, Pieler T., Dev Biol. March 15, 2020; 459 (2): 138-148.                                

Pinhead signaling regulates mesoderm heterogeneity via FGF receptor-dependent pathway., Ossipova O, Itoh K, Radu A, Ezan J, Sokol SY., Development. January 1, 2020;                                       

PTK7 proteolytic fragment proteins function during early Xenopus development., Lichtig H, Cohen Y, Bin-Nun N, Golubkov V, Frank D., Dev Biol. September 1, 2019; 453 (1): 48-55.        

The Spatiotemporal Control of Zygotic Genome Activation., Gentsch GE, Owens NDL, Smith JC., iScience. June 28, 2019; 16 485-498.                          

Mechanical strain, novel genes and evolutionary insights: news from the frog left-right organizer., Blum M, Ott T., Curr Opin Genet Dev. June 1, 2019; 56 8-14.      

A dual function of FGF signaling in Xenopus left-right axis formation., Schneider I, Kreis J, Schweickert A, Blum M, Vick P., Development. May 10, 2019; 146 (9):                               

Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway., Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E., Mech Dev. April 1, 2019; 156 20-31.                              

Non-acylated Wnts Can Promote Signaling., Speer KF, Sommer A, Tajer B, Mullins MC, Klein PS, Lemmon MA., Cell Rep. January 22, 2019; 26 (4): 875-883.e5.                  

WDR5 regulates left-right patterning via chromatin-dependent and -independent functions., Kulkarni SS, Khokha MK., Development. November 28, 2018; 145 (23):                 

Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates., Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q, Tao Q, Meng A., Science. November 23, 2018; 362 (6417):


Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis., Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM., Proc Natl Acad Sci U S A. September 25, 2018; 115 (39): E9135-E9144.                    

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus., Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M., iScience. April 27, 2018; 2 76-85.                                        

Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1., Lee H, Lee H, Cheong SM, Han W, Koo Y, Jo SB, Cho GS, Yang JS, Kim S, Han JK., Development. April 10, 2018; 145 (7):               

Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR., Li X, Fok KL, Guo J, Wang Y, Liu Z, Chen Z, Wang C, Ruan YC, Yu SS, Zhao H, Wu J, Jiang X, Chan HC., Biochim Biophys Acta Mol Cell Res. April 1, 2018; 1865 (4): 605-615.

RAPGEF5 Regulates Nuclear Translocation of β-Catenin., Griffin JN, Del Viso F, Duncan AR, Robson A, Hwang W, Kulkarni S, Liu KJ, Liu KJ, Khokha MK., Dev Cell. January 22, 2018; 44 (2): 248-260.e4.                                                

Candidate Heterotaxy Gene FGFR4 Is Essential for Patterning of the Left-Right Organizer in Xenopus., Sempou E, Lakhani OA, Amalraj S, Khokha MK., Front Physiol. January 1, 2018; 9 1705.              

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.                                

The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus., Zhu X, Xing R, Tan R, Dai R, Tao Q, Tao Q., Mech Dev. October 1, 2017; 147 28-36.              

Both Nuclear Size and DNA Amount Contribute to Midblastula Transition Timing in Xenopus laevis., Jevtić P, Levy DL., Sci Rep. August 11, 2017; 7 (1): 7908.            

Two-Element Transcriptional Regulation in the Canonical Wnt Pathway., Kim K, Cho J, Hilzinger TS, Nunns H, Liu A, Ryba BE, Goentoro L., Curr Biol. August 7, 2017; 27 (15): 2357-2364.e5.                

Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula., Ding Y, Colozza G, Zhang K, Moriyama Y, Ploper D, Sosa EA, Benitez MDJ, De Robertis EM., Dev Biol. June 15, 2017; 426 (2): 176-187.                                  

Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing., Popov IK, Kwon T, Crossman DK, Crowley MR, Wallingford JB, Chang C., Dev Biol. June 15, 2017; 426 (2): 429-441.                    

Genome organization of the vg1 and nodal3 gene clusters in the allotetraploid frog Xenopus laevis., Suzuki A, Uno Y, Takahashi S, Grimwood J, Schmutz J, Mawaribuchi S, Yoshida H, Takebayashi-Suzuki K, Ito M, Matsuda Y, Rokhsar D, Taira M., Dev Biol. June 15, 2017; 426 (2): 236-244.            

High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis., Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T., Dev Biol. June 15, 2017; 426 (2): 270-290.                  

The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning., Rauschenberger V, Bernkopf DB, Krenn S, Jalal K, Heller J, Behrens J, Gentzel M, Schambony A., Development. June 15, 2017; 144 (12): 2234-2247.                                      

Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition., Wagner G, Singhal N, Nicetto D, Straub T, Kremmer E, Rupp RAW., PLoS Genet. May 12, 2017; 13 (5): e1006757.                                    

Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis., Ding Y, Ploper D, Sosa EA, Colozza G, Moriyama Y, Benitez MD, Zhang K, Merkurjev D, De Robertis EM., Proc Natl Acad Sci U S A. April 11, 2017; 114 (15): E3081-E3090.                        

The MLL/Setd1b methyltransferase is required for the Spemann's organizer gene activation in Xenopus., Lin H, Min Z, Tao Q, Tao Q., Mech Dev. November 1, 2016; 142 1-9.              

Cholesterol-rich membrane microdomains modulate Wnt/β-catenin morphogen gradient during Xenopus development., Reis AH, Moreno MM, Maia LA, Oliveira FP, Santos AS, Abreu JG., Mech Dev. November 1, 2016; 142 30-39.                        

Genome evolution in the allotetraploid frog Xenopus laevis., Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS., Nature. October 20, 2016; 538 (7625): 336-343.                              

Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation., Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J, Jho EH., Cell Death Differ. October 1, 2016; 23 (10): 1638-47.

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin., Gillis WQ, Kirmizitas A, Iwasaki Y, Ki DH, Wyrick JM, Thomsen GH., Cell Commun Signal. August 2, 2016; 14 (1): 15.              

Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules., Nakamura Y, de Paiva Alves E, Veenstra GJ, Hoppler S., Development. June 1, 2016; 143 (11): 1914-25.            

A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators., Park S, Blaser S, Marchal MA, Houston DW, Sheets MD., Development. March 1, 2016; 143 (5): 864-71.          

Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development., Owens ND, Blitz IL, Lane MA, Patrushev I, Overton JD, Gilchrist MJ, Cho KW, Khokha MK., Cell Rep. January 26, 2016; 14 (3): 632-47.                                                  

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