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Summary Expression Phenotypes Gene Literature (98) GO Terms (0) Nucleotides (369) Proteins (59) Interactants (464) Wiki
XB--6031745

Papers associated with ttn



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referenced by:

Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues., Lummis SCR, Dougherty DA., Membranes (Basel). October 19, 2022; 12 (10):


Identification of SCN5a p.C335R Variant in a Large Family with Dilated Cardiomyopathy and Conduction Disease., Sedaghat-Hamedani F, Rebs S, El-Battrawy I, Chasan S, Krause T, Haas J, Zhong R, Liao Z, Xu Q, Zhou X, Akin I, Zitron E, Frey N, Streckfuss-Bömeke K, Kayvanpour E., Int J Mol Sci. November 30, 2021; 22 (23):             

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel., Bergh C, Heusser SA, Howard R, Lindahl E., Elife. October 15, 2021; 10                                             

Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation., Langer K, Müller-Längle A, Wempe J, Laube B., Front Pharmacol. October 1, 2021; 12 769046.            

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation., Lefebvre SN, Taly A, Menny A, Medjebeur K, Corringer PJ., Elife. September 30, 2021; 10                               

GluN2A and GluN2B NMDA receptors use distinct allosteric routes., Tian M, Stroebel D, Piot L, David M, Ye S, Paoletti P., Nat Commun. August 5, 2021; 12 (1): 4709.                

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs., Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S., Nat Commun. July 27, 2020; 11 (1): 3752.            

Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles., Mori T, Kitani Y, Hatakeyama D, Machida K, Goto-Inoue N, Hayakawa S, Yamamoto N, Kashiwagi K, Kashiwagi A., Sci Rep. July 16, 2020; 10 (1): 11737.                    

Aromatic interactions with membrane modulate human BK channel activation., Yazdani M, Zhang G, Jia Z, Shi J, Cui J, Chen J., Elife. June 29, 2020; 9                                     

A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors., Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW., Eur J Med Chem. May 15, 2020; 194 112261.

Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor., Nebrisi EE, Prytkova T, Lorke DE, Howarth L, Alzaabi AH, Yang KS, Howarth FC, Oz M., Front Pharmacol. April 7, 2020; 11 1274.            

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors., Wang JX, Irvine MW, Burnell ES, Sapkota K, Thatcher RJ, Li M, Simorowski N, Volianskis A, Collingridge GL, Monaghan DT, Jane DE, Furukawa H., Nat Commun. January 22, 2020; 11 (1): 423.              

Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2., Levine TP., F1000Res. January 1, 2020; 9 1052.          

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor., Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S., Nat Commun. July 19, 2019; 10 (1): 3225.                                    

Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence., Liao Y, Chang HC, Liang FX, Chung PJ, Wei Y, Nguyen TP, Zhou G, Talebian S, Krey LC, Deng FM, Wong TW, Chicote JU, Grifo JA, Keefe DL, Shapiro E, Lepor H, Wu XR, DeSalle R, Garcia-España A, Kim SY, Sun TT., Mol Biol Cell. December 15, 2018; 29 (26): 3128-3143.                  

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors., Grand T, Abi Gerges S, David M, Diana MA, Paoletti P., Nat Commun. November 13, 2018; 9 (1): 4769.            

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor., Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S., Nature. November 1, 2018; 563 (7730): 270-274.

Structural basis of neurosteroid anesthetic action on GABAA receptors., Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Xu Y, Tang P., Nat Commun. September 28, 2018; 9 (1): 3972.              

The roles of aromatic residues in the glycine receptor transmembrane domain., Tang B, Lummis SCR., BMC Neurosci. September 6, 2018; 19 (1): 53.                  

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups., Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF., Elife. May 24, 2018; 7                                                                         

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels., Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M., Cell Rep. April 24, 2018; 23 (4): 993-1004.                          

Cryo-EM structure of 5-HT3A receptor in its resting conformation., Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S., Nat Commun. February 6, 2018; 9 (1): 514.          

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation., Ghosh B, Tsao TW, Czajkowski C., Neuropharmacology. October 1, 2017; 125 343-352.

Probing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling., Zheng W, Wen H, Iacobucci GJ, Popescu GK., Biophys J. June 20, 2017; 112 (12): 2589-2601.

Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras - role of the GLIC transmembrane domain in proton sensing., Hénault CM, Baenziger JE., Biochim Biophys Acta Biomembr. February 1, 2017; 1859 (2): 218-227.

A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors., Bryant DM, Johnson K, DiTommaso T, Tickle T, Couger MB, Payzin-Dogru D, Lee TJ, Leigh ND, Kuo TH, Davis FG, Bateman J, Bryant S, Guzikowski AR, Tsai SL, Coyne S, Ye WW, Freeman RM, Peshkin L, Tabin CJ, Regev A, Haas BJ, Whited JL., Cell Rep. January 17, 2017; 18 (3): 762-776.                          

Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels., Lü S, An H, Zhang H, Long M., Mol Neurobiol. November 1, 2016; 53 (9): 5948-5961.                

Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers., Tian M, Ye S., Sci Rep. October 7, 2016; 6 34751.              

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors., Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY., Neuron. October 5, 2016; 92 (1): 143-159.                                  

CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart., Blech-Hermoni Y, Sullivan CB, Jenkins MW, Wessely O, Ladd AN., Dev Dyn. August 1, 2016; 245 (8): 854-73.                      

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists., Stroebel D, Buhl DL, Knafels JD, Chanda PK, Green M, Sciabola S, Mony L, Paoletti P, Pandit J., Mol Pharmacol. May 1, 2016; 89 (5): 541-51.          

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels., Kinde MN, Bu W, Chen Q, Xu Y, Xu Y, Eckenhoff RG, Tang P., Anesthesiology. March 1, 2016; 124 (3): 664-73.

A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels., Emerit MB, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, Masson J, Boué-Grabot E, Darmon M., J Neurosci. February 3, 2016; 36 (5): 1456-70.  

A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation., Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S., J Gen Physiol. October 1, 2015; 146 (4): 323-40.              

A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane., Pan Y, Laird JG, Yamaguchi DM, Baker SA., Cell Mol Life Sci. February 1, 2015; 72 (4): 833-43.            

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis., Nworu CU, Kraft R, Schnurr DC, Gregorio CC, Krieg PA., J Cell Sci. January 15, 2015; 128 (2): 239-50.                                                  

Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3- cotransporters., Wang DK, Liu Y, Myers EJ, Guo YM, Xie ZD, Jiang DZ, Li JM, Yang J, Liu M, Parker MD, Chen LM., Sci Rep. January 12, 2015; 5 12241.                            

NMDA receptor structures reveal subunit arrangement and pore architecture., Lee CH, Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E., Nature. July 10, 2014; 511 (7508): 191-7.                          

State-dependent network connectivity determines gating in a K+ channel., Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T., Structure. July 8, 2014; 22 (7): 1037-46.              

Impact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors., Kozuska JL, Paulsen IM, Belfield WJ, Martin IL, Cole DJ, Holt A, Dunn SM., Br J Pharmacol. April 1, 2014; 171 (7): 1617-28.      

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation., Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M., Proc Natl Acad Sci U S A. January 21, 2014; 111 (3): 966-71.        

Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavities., Ghosh B, Satyshur KA, Czajkowski C., J Biol Chem. June 14, 2013; 288 (24): 17420-31.

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels., Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L, Thompson AW, Koehl P, Corringer PJ, Baaden M, Delarue M., EMBO J. March 6, 2013; 32 (5): 728-41.                

Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels., Inanobe A, Nakagawa A, Kurachi Y., PLoS One. January 1, 2013; 8 (11): e79844.              

Pressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences., Mor A, Kuttner YY, Levy S, Mor M, Hollmann M, Grossman Y., Front Cell Neurosci. September 11, 2012; 6 37.            

Microarray-based identification of Pitx3 targets during Xenopus embryogenesis., Hooker L, Smoczer C, KhosrowShahian F, Wolanski M, Crawford MJ., Dev Dyn. September 1, 2012; 241 (9): 1487-505.                          

Analysis and elimination of a bias in targeted molecular dynamics simulations of conformational transitions: application to calmodulin., Ovchinnikov V, Karplus M., J Phys Chem B. July 26, 2012; 116 (29): 8584-603.

In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV., Hsu HJ, Fischer WB., J Mol Model. February 1, 2012; 18 (2): 501-14.              

Tryptophan scanning mutagenesis reveals distortions in the helical structure of the δM4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor., Caballero-Rivera D, Cruz-Nieves OA, Oyola-Cintrón J, Torres-Nunez DA, Otero-Cruz JD, Lasalde-Dominicci JA., Channels (Austin). January 1, 2012; 6 (2): 111-23.

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors., Riou M, Stroebel D, Edwardson JM, Paoletti P., PLoS One. January 1, 2012; 7 (4): e35134.        

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