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Summary Expression Phenotypes Gene Literature (30) GO Terms (10) Nucleotides (259) Proteins (92) Interactants (888) Wiki
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Papers associated with grb2



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Paradoxical activation of c-Src as a drug-resistant mechanism., Higuchi M, Ishiyama K, Maruoka M, Kanamori R, Takaori-Kondo A, Watanabe N., Cell Rep. March 23, 2021; 34 (12): 108876.  

Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis., Kinoshita N, Hashimoto Y, Yasue N, Suzuki M, Suzuki M, Cristea IM, Ueno N., Cell Rep. March 17, 2020; 30 (11): 3875-3888.e3.                

The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism., Yang JJ, Bertolesi GE, Dueck S, Hehr CL, McFarlane S., eNeuro. April 9, 2019; 6 (2):                   

SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways., Morel M, Vanderstraete M, Cailliau K, Hahnel S, Grevelding CG, Dissous C., PLoS One. January 1, 2016; 11 (9): e0163283.                  

Atypical RhoV and RhoU GTPases control development of the neural crest., Faure S, Fort P., Small GTPases. October 2, 2015; 6 (4): 174-7.

Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites., Kim YJ, Bahn M, Kim YH, Shin JY, Cheong SW, Ju BG, Kim WS, Yeo CY., Dev Biol. January 1, 2015; 397 (1): 129-39.                                          

A microinjectable biological system, the Xenopus oocyte, as an approach to understanding signal transduction protein function., Cailliau K, Browaeys-Poly E., Methods Mol Biol. January 1, 2009; 518 43-55.

Signal transduction of fertilization in frog eggs and anti-apoptotic mechanism in human cancer cells: common and specific functions of membrane microdomains., Sato K., Open Biochem J. January 1, 2008; 2 49-59.        

A non-canonical Grb2-PLC-gamma1-Sos cascade triggered by lipovitellin 1, an apolipoprotein B homologue., Browaeys-Poly E, Broutin I, Antoine AF, Marin M, Lescuyer A, Vilain JP, Ducruix A, Cailliau K., Cell Signal. December 1, 2007; 19 (12): 2540-8.

Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor., Mood K, Saucier C, Bong YS, Lee HS, Park M, Daar IO., Mol Biol Cell. September 1, 2006; 17 (9): 3717-28.

Oncogenic Met receptor induces ectopic structures in Xenopus embryos., Ishimura A, Lee HS, Bong YS, Saucier C, Mood K, Park EK, Daar IO., Oncogene. July 20, 2006; 25 (31): 4286-99.

Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling., Mood K, Saucier C, Ishimura A, Bong YS, Lee HS, Park M, Daar IO., J Cell Physiol. April 1, 2006; 207 (1): 271-85.

Molecular cloning and characterization of an adaptor protein Shc isoform from Xenopus laevis oocytes., Chesnel F, Heligon C, Richard-Parpaillon L, Boujard D., Biol Cell. July 1, 2003; 95 (5): 311-20.

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway., Hanafusa H, Torii S, Yasunaga T, Nishida E., Nat Cell Biol. November 1, 2002; 4 (11): 850-8.

Interaction of the IP(3)-Ca(2+) and the FGF-MAPK signaling pathways in the Xenopus laevis embryo: a qualitative approach to the mesodermal induction problem., Díaz J, Baier G, Martínez-Mekler G, Pastor N., Biophys Chem. May 23, 2002; 97 (1): 55-72.

Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo., Kusakabe M, Masuyama N, Hanafusa H, Nishida E., EMBO Rep. August 1, 2001; 2 (8): 727-35.

Transduction cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cgamma., Browaeys-Poly E, Cailliau K, Vilain JP., Cell Signal. May 1, 2001; 13 (5): 363-8.

Grb2 promotes reinitiation of meiosis in Xenopus oocytes., Cailliau K, Browaeys-Poly E, Broutin-L'Hermite I, Nioche P, Garbay C, Ducruix A, Vilain JP., Cell Signal. January 1, 2001; 13 (1): 51-5.

Signal transduction pathways triggered by fibroblast growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition. Role of Grb2, phosphatidylinositol 3-kinase, Src tyrosine kinase, and phospholipase Cgamma., Browaeys-Poly E, Cailliau K, Vilain JP., Eur J Biochem. October 1, 2000; 267 (20): 6256-63.

Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus., Dupont H, Blancq M., Eur J Biochem. October 1, 1999; 265 (2): 530-8.

Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner., Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD., Mol Cell Biol. June 1, 1999; 19 (6): 4379-89.

A 58-kDa Shc protein is present in Xenopus eggs and is phosphorylated on tyrosine residues upon egg activation., Aoto M, Sato K, Takeba S, Horiuchi Y, Iwasaki T, Tokmakov AA, Fukami Y., Biochem Biophys Res Commun. May 10, 1999; 258 (2): 265-70.

Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1., Rojas JM, Subleski M, Coque JJ, Guerrero C, Saez R, Li BQ, Lopez E, Zarich N, Aroca P, Kamata T, Santos E., Oncogene. March 4, 1999; 18 (9): 1651-61.

Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus., Gupta RW, Mayer BJ., Oncogene. October 29, 1998; 17 (17): 2155-65.

A novel insulin receptor substrate protein, xIRS-u, potentiates insulin signaling: functional importance of its pleckstrin homology domain., Ohan N, Bayaa M, Kumar P, Zhu L, Liu XJ., Mol Endocrinol. August 1, 1998; 12 (8): 1086-98.

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck., Lu W, Katz S, Gupta R, Mayer BJ., Curr Biol. February 1, 1997; 7 (2): 85-94.

Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes., Yamamoto-Honda R, Honda Z, Ueki K, Tobe K, Kaburagi Y, Takahashi Y, Tamemoto H, Suzuki T, Itoh K, Akanuma Y, Yazaki Y, Kadowaki T., J Biol Chem. November 8, 1996; 271 (45): 28677-81.

Functional interactions between isolated SH2 domains and insulin/Ras signaling pathways of Xenopus oocytes: opposite effects of the carboxy- and amino-terminal SH2 domains of p85 PI 3-kinase., Aroca P, Mahadevan D, Santos E., Oncogene. November 7, 1996; 13 (9): 1839-46.

Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation., Liu XJ, Sorisky A, Zhu L, Pawson T., Mol Cell Biol. July 1, 1995; 15 (7): 3563-70.

Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes., Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR., J Biol Chem. November 4, 1994; 269 (44): 27645-9.

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