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Summary Expression Phenotypes Gene Literature (134) GO Terms (8) Nucleotides (127) Proteins (56) Interactants (157) Wiki
XB--923159

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Subacute toxicity and endocrine-disrupting effects of Fe2O3, ZnO, and CeO2 nanoparticles on amphibian metamorphosis., Arslan E, Güngördü A., Environ Sci Pollut Res Int. January 1, 2024; 31 (3): 4174-4195.

Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease., Gutti G, Leifeld J, Kakarla R, Bajad NG, Ganeshpurkar A, Kumar A, Krishnamurthy S, Klein-Schmidt C, Tapken D, Hollmann M, Singh SK., Eur J Med Chem. November 5, 2023; 259 115670.

Impacts of aqueous extracts of wildfire ashes on aquatic life-stages of Xenopus laevis: Influence of plant coverage., Santos D, Abrantes N, Campos I, Domingues I, Lopes I., Aquat Toxicol. September 1, 2023; 262 106664.            

The Amphibian Short-Term Assay: Evaluation of a New Ecotoxicological Method for Amphibians Using Two Organophosphate Pesticides Commonly Found in Nature-Assessment of Biochemical, Morphological, and Life-History Traits., Boualit L, Cayuela H, Cattin L, Chèvre N., Environ Toxicol Chem. November 1, 2022; 41 (11): 2688-2699.          

Developmental, toxicological effects and recovery patterns in Xenopus laevis after exposure to penconazole-based fungicide during the metamorphosis process., Turhan DO, Güngördü A., Chemosphere. September 1, 2022; 303 (Pt 3): 135302.

Biochemical and osmoregulatory responses of the African clawed frog experimentally exposed to salt and pesticide., Álvarez-Vergara F, Sanchez-Hernandez JC, Sabat P., Comp Biochem Physiol C Toxicol Pharmacol. August 1, 2022; 258 109367.

Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles., Ta AC, Huang LC, McKeown CR, Bestman JE, Van Keuren-Jensen K, Cline HT., G3 (Bethesda). January 4, 2022; 12 (1):               

Juvenile African Clawed Frogs (Xenopus laevis) Express Growth, Metamorphosis, Mortality, Gene Expression, and Metabolic Changes When Exposed to Thiamethoxam and Clothianidin., Jenkins JA, Hartop KR, Bukhari G, Howton DE, Smalling KL, Mize SV, Hladik ML, Johnson D, Draugelis-Dale RO, Brown BL., Int J Mol Sci. December 10, 2021; 22 (24):                     

Evaluating Multiple Biochemical Markers in Xenopus laevis Tadpoles Exposed to the Pesticides Thiacloprid and Trifloxystrobin in Single and Mixed Forms., Uçkun M, Özmen M., Environ Toxicol Chem. October 1, 2021; 40 (10): 2846-2860.

Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR., Epstein M, Bali K, Piggot TJ, Green AC, Timperley CM, Bird M, Tattersall JEH, Bermudez I, Biggin PC., Toxicol Lett. April 1, 2021; 340 114-122.

Building neuromuscular junctions in vitro., Barbeau S, Tahraoui-Bories J, Legay C, Martinat C., Development. November 16, 2020; 147 (22):       

Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor., Cieslikiewicz-Bouet M, Naldi M, Bartolini M, Pérez B, Servent D, Jean L, Aráoz R, Renard PY., Biochem Pharmacol. July 1, 2020; 177 114010.

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System., Akimov MG, Kudryavtsev DS, Kryukova EV, Fomina-Ageeva EV, Zakharov SS, Gretskaya NM, Zinchenko GN, Serkov IV, Makhaeva GF, Boltneva NP, Kovaleva NV, Serebryakova OG, Lushchekina SV, Palikov VA, Palikova Y, Dyachenko IA, Kasheverov IE, Tsetlin VI, Bezuglov VV., Biomolecules. February 12, 2020; 10 (2):


Biochemical responses revealed in an amphibian species after exposure to a forgotten contaminant: An integrated biomarker assessment., Dahms-Verster S, Nel A, van Vuren JHJ, Greenfield R., Environ Toxicol Pharmacol. January 1, 2020; 73 103272.

Linking organochlorine exposure to biomarker response patterns in Anurans: a case study of Müller's clawed frog (Xenopus muelleri) from a tropical malaria vector control region., Wolmarans NJ, Du Preez LH, Yohannes YB, Ikenaka Y, Ishizuka M, Smit NJ, Wepener V., Ecotoxicology. November 1, 2018; 27 (9): 1203-1216.

Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors., Kowal NM, Ahring PK, Liao VWY, Indurti DC, Harvey BS, O'Connor SM, Chebib M, Olafsdottir ES, Balle T., Br J Pharmacol. July 1, 2018; 175 (14): 2911-2925.

Determination of the Residues in the Extracellular Domain of the Nicotinic α Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors., Jin X, Germann AL, Shin DJ, Akk G, Steinbach JH., Mol Pharmacol. September 1, 2017; 92 (3): 318-326.

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis., Pickett MA, Dush MK, Nascone-Yoder NM., Development. August 1, 2017; 144 (15): 2764-2770.                    

The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors., Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH., Mol Pharmacol. February 1, 2017; 91 (2): 100-109.

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment., Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E, Fedunova D, Horak M, Kaniakova M, Wang ZJ, Hamouda AK, Kuca K., Biochim Biophys Acta Mol Basis Dis. February 1, 2017; 1863 (2): 607-619.

Integrated assessment of biochemical markers in premetamorphic tadpoles of three amphibian species exposed to glyphosate- and methidathion-based pesticides in single and combination forms., Güngördü A, Uçkun M, Yoloğlu E., Chemosphere. February 1, 2016; 144 2024-35.

Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis., Tanizaki Y, Ichisugi M, Obuchi-Shimoji M, Ishida-Iwata T, Tahara-Mogi A, Meguro-Ishikawa M, Kato T., Sci Rep. December 21, 2015; 5 18519.                                

Low concentrations of metal mixture exposures have adverse effects on selected biomarkers of Xenopus laevis tadpoles., Yologlu E, Ozmen M., Aquat Toxicol. November 1, 2015; 168 19-27.

Comparative assessment of in vitro and in vivo toxicity of azinphos methyl and its commercial formulation., Güngördü A, Uçkun M., Environ Toxicol. September 1, 2015; 30 (9): 1091-101.

Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis., Preud'homme V, Milla S, Gillardin V, De Pauw E, Denoël M, Kestemont P., Chemosphere. February 1, 2015; 120 357-64.

Organophosphate pesticides induce morphological abnormalities and decrease locomotor activity and heart rate in Danio rerio and Xenopus laevis., Watson FL, Schmidt H, Turman ZK, Hole N, Garcia H, Gregg J, Tilghman J, Fradinger EA., Environ Toxicol Chem. June 1, 2014; 33 (6): 1337-45.

Comparative toxicity of methidathion and glyphosate on early life stages of three amphibian species: Pelophylax ridibundus, Pseudepidalea viridis, and Xenopus laevis., Güngördü A., Aquat Toxicol. September 15, 2013; 140-141 220-8.

RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation., Dau A, Komal P, Truong M, Morris G, Evans G, Nashmi R., BMC Neurosci. April 15, 2013; 14 47.                

Evaluation of in vitro and in vivo toxic effects of newly synthesized benzimidazole-based organophosphorus compounds., Güngördü A, Sireci N, Küçükbay H, Birhanli A, Ozmen M., Ecotoxicol Environ Saf. January 1, 2013; 87 23-32.

The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors., Grandič M, Aráoz R, Molgó J, Turk T, Sepčić K, Benoit E, Frangež R., Toxicol Appl Pharmacol. December 1, 2012; 265 (2): 221-8.

Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake., Ruggiero AM, Wright J, Ferguson SM, Lewis M, Emerson KS, Iwamoto H, Ivy MT, Holmstrand EC, Ennis EA, Weaver CD, Blakely RD., ACS Chem Neurosci. October 17, 2012; 3 (10): 767-81.

Toxic effects of deltamethrin and λ-cyhalothrin on Xenopus laevis tadpoles., Aydin-Sinan H, Güngördü A, Ozmen M., J Environ Sci Health B. January 1, 2012; 47 (5): 397-402.

An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses., Mongeon R, Walogorsky M, Urban J, Mandel G, Ono F, Brehm P., J Gen Physiol. September 1, 2011; 138 (3): 353-66.                      

Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine receptors., Rozman KB, Araoz R, Sepi K, Molgo J, Suput D., Chem Biol Interact. September 6, 2010; 187 (1-3): 384-7.

Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte., Li XY, Zhang J, Dai JP, Liu XM, Li ZW., Dev Biol. March 8, 2010; 1318 23-32.

Molecular characterization of Hydra acetylcholinesterase and its catalytic activity., Takahashi T, Hamaue N., FEBS Lett. February 5, 2010; 584 (3): 511-6.

Enteric co-innervation of esophageal striated muscle fibers: a phylogenetic study., Hempfling C, Seibold R, Shiina T, Heimler W, Neuhuber WL, Wörl J., Auton Neurosci. December 3, 2009; 151 (2): 135-41.

Axial-skeletal defects caused by Carbaryl in Xenopus laevis embryos., Bacchetta R, Mantecca P, Andrioletti M, Vismara C, Vailati G., Sci Total Environ. March 15, 2008; 392 (1): 110-8.

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels., Nie H, Yu WJ, Li XY, Yuan CH, Pang YP, Li CY, Han YF, Li ZW., Neurosci Lett. January 29, 2007; 412 (2): 108-13.

A peptide derived from acetylcholinesterase is a pivotal signalling molecule in neurodegeneration., Greenfield S., Chem Biol Interact. December 15, 2005; 157-158 211-8.

Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus laevis larvae., Colombo A, Orsi F, Bonfanti P., Chemosphere. December 1, 2005; 61 (11): 1665-71.

Expression and comparative functional characterisation of recombinant acetylcholinesterase from three species of Schistosoma., Bentley GN, Jones AK, Agnew A., Mol Biochem Parasitol. May 1, 2005; 141 (1): 119-23.

The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane., Olivera-Bravo S, Ivorra I, Morales A., Br J Pharmacol. January 1, 2005; 144 (1): 88-97.

Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development., Bonfanti P, Colombo A, Orsi F, Nizzetto I, Andrioletti M, Bacchetta R, Mantecca P, Fascio U, Vailati G, Vismara C., Aquat Toxicol. December 10, 2004; 70 (3): 189-200.

Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides., Smulders CJ, Bueters TJ, Vailati S, van Kleef RG, Vijverberg HP., Toxicol Sci. December 1, 2004; 82 (2): 545-54.

P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions., Tung EK, Choi RC, Siow NL, Jiang JX, Ling KK, Simon J, Barnard EA, Tsim KW., Mol Pharmacol. October 1, 2004; 66 (4): 794-806.

Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons., Fayuk D, Yakel JL., Mol Pharmacol. September 1, 2004; 66 (3): 658-66.

A novel peptide modulates alpha7 nicotinic receptor responses: implications for a possible trophic-toxic mechanism within the brain., Greenfield SA, Day T, Mann EO, Bermudez I., J Neurochem. July 1, 2004; 90 (2): 325-31.

Role of piperonyl butoxide in the toxicity of chlorpyrifos to Ceriodaphnia dubia and Xenopus laevis., El-Merhibi A, Kumar A, Smeaton T., Ecotoxicol Environ Saf. February 1, 2004; 57 (2): 202-12.

Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase., Smulders CJ, Bueters TJ, Van Kleef RG, Vijverberg HP., Toxicol Appl Pharmacol. December 1, 2003; 193 (2): 139-46.

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