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Summary Expression Phenotypes Gene Literature (35) GO Terms (3) Nucleotides (196) Proteins (54) Interactants (90) Wiki
XB--942770

Papers associated with rgs4



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Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways., Seldeslachts A, Peigneur S, Tytgat J., Membranes (Basel). December 2, 2023; 13 (12):               

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2., Burström V, Ågren R, Betari N, Valle-León M, Garro-Martínez E, Ciruela F, Sahlholm K., Front Pharmacol. January 1, 2023; 14 1087171.          

WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels., An D, Peigneur S, Tytgat J., Biomedicines. April 28, 2021; 9 (5):               

Dopamine D2 Receptor Agonist Binding Kinetics-Role of a Conserved Serine Residue., Ågren R, Stepniewski TM, Zeberg H, Selent J, Sahlholm K., Int J Mol Sci. April 15, 2021; 22 (8):                     

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism., Ågren R, Zeberg H, Stępniewski TM, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K., ACS Chem Neurosci. October 7, 2020; 11 (19): 3130-3143.            

The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation., Ågren R, Århem P, Nilsson J, Sahlholm K., Int J Neuropsychopharmacol. December 1, 2018; 21 (12): 1102-1108.    

The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels., Freitas ACN, Peigneur S, Macedo FHP, Menezes-Filho JE, Millns P, Medeiros LF, Arruda MA, Cruz J, Holliday ND, Tytgat J, Hathway G, de Lima ME., Toxins (Basel). January 15, 2018; 10 (1):             

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity., Chen IS, Furutani K, Kurachi Y., Sci Rep. July 21, 2017; 7 (1): 6110.          

RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents., Chen IS, Furutani K, Inanobe A, Kurachi Y., J Physiol. March 15, 2014; 592 (6): 1237-48.            

Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells., Ghil S, McCoy KL, Hepler JR., PLoS One. January 1, 2014; 9 (4): e95355.          

Thyroid hormone-dependent development in Xenopus laevis: a sensitive screen of thyroid hormone signaling disruption by municipal wastewater treatment plant effluent., Searcy BT, Beckstrom-Sternberg SM, Beckstrom-Sternberg JS, Stafford P, Schwendiman AL, Soto-Pena J, Owen MC, Ramirez C, Phillips J, Veldhoen N, Helbing CC, Propper CR., Gen Comp Endocrinol. May 1, 2012; 176 (3): 481-92.

RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo., Chuang HH, Chuang AY., Sci Signal. February 21, 2012; 5 (212): ra15.

Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation., Schneider PN, Slusarski DC, Houston DW., PLoS One. January 1, 2012; 7 (9): e44096.                

The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes., Sahlholm K., Biochem Biophys Res Commun. November 25, 2011; 415 (3): 509-14.

RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors., Celver J, Sharma M, Kovoor A., J Neurochem. August 1, 2010; 114 (3): 739-49.

Identification of peptides that inhibit regulator of G protein signaling 4 function., Wang Y, Lee Y, Zhang J, Young KH., Pharmacology. January 1, 2008; 82 (2): 97-104.

Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors., Wang X, Zeng W, Kim MS, Allen PB, Greengard P, Muallem S., EMBO J. June 6, 2007; 26 (11): 2768-76.

RGS3 and RGS4 differentially associate with G protein-coupled receptor-Kir3 channel signaling complexes revealing two modes of RGS modulation. Precoupling and collision coupling., Jaén C, Doupnik CA., J Biol Chem. November 10, 2006; 281 (45): 34549-60.

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors., Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S., Nat Cell Biol. April 1, 2005; 7 (4): 405-11.

Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action., Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y., Biochem J. January 1, 2005; 385 (Pt 1): 65-73.

Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation., Zhang Q, Pacheco MA, Doupnik CA., J Physiol. December 1, 2002; 545 (2): 355-73.

N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai., Ippolito DL, Temkin PA, Rogalski SL, Chavkin C., J Biol Chem. September 6, 2002; 277 (36): 32692-6.

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha., Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E., J Biol Chem. September 6, 2002; 277 (36): 32954-62.

Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies., Ulens C, Baker L, Ratka A, Waumans D, Tytgat J., Biochem Pharmacol. November 1, 2001; 62 (9): 1273-82.

The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists., Pil J, Tytgat J., Br J Pharmacol. October 1, 2001; 134 (3): 496-506.

Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel., Inanobe A, Fujita S, Makino Y, Matsushita K, Ishii M, Chachin M, Kurachi Y., J Physiol. August 15, 2001; 535 (Pt 1): 133-43.

Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5., Keren-Raifman T, Bera AK, Zveig D, Peleg S, Witherow DS, Slepak VZ, Dascal N., FEBS Lett. March 9, 2001; 492 (1-2): 20-8.

Changes in GIRK1/GIRK2 deactivation kinetics and basal activity in the presence and absence of RGS4., Ulens C, Daenens P, Tytgat J., Life Sci. September 29, 2000; 67 (19): 2305-17.

Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity., Ulens C, Van Boven M, Daenens P, Tytgat J., J Pharmacol Exp Ther. September 1, 2000; 294 (3): 1024-33.

A regulator of G protein signalling (RGS) protein confers agonist-dependent relaxation gating to a G protein-gated K+ channel., Fujita S, Inanobe A, Chachin M, Aizawa Y, Kurachi Y., J Physiol. July 15, 2000; 526 Pt 2 341-7.

RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development., Wu C, Zeng Q, Blumer KJ, Muslin AJ., Development. July 1, 2000; 127 (13): 2773-84.    

Molecular cloning and characterization of Xenopus RGS5., Saitoh O, Odagiri M, Masuho I, Nomoto S, Kinoshita N., Biochem Biophys Res Commun. April 2, 2000; 270 (1): 34-9.        

Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins., Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA., J Biol Chem. February 4, 2000; 275 (5): 3397-402.

RGS4 inhibits signaling by group I metabotropic glutamate receptors., Saugstad JA, Marino MJ, Folk JA, Hepler JR, Conn PJ., J Neurosci. February 1, 1998; 18 (3): 905-13.

RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels., Doupnik CA, Davidson N, Lester HA, Kofuji P., Proc Natl Acad Sci U S A. September 16, 1997; 94 (19): 10461-6.

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