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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 ( TRPV4) to Cause Inflammation and Pain. , Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW., J Biol Chem. May 29, 2015; 290 (22): 13875-87.
Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. , Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S., Pflugers Arch. April 1, 2015; 467 (4): 687-701.
Getting to know your neighbor: cell polarization in early embryos. , Nance J., J Cell Biol. September 29, 2014; 206 (7): 823-32.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. , Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW., J Biol Chem. September 26, 2014; 289 (39): 27215-27234.
Regulator of G protein signaling 2 ( RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 ( PAR1) in live cells. , Ghil S, McCoy KL, Hepler JR., PLoS One. January 1, 2014; 9 (4): e95355.
Plasma membrane events associated with the meiotic divisions in the amphibian oocyte: insights into the evolution of insulin transduction systems and cell signaling. , Morrill GA, Kostellow AB, Moore RD, Gupta RK ., BMC Dev Biol. January 23, 2013; 13 3.
Signaling crosstalk between TGFβ and Dishevelled/ Par1b. , Mamidi A, Inui M, Manfrin A, Soligo S, Enzo E, Aragona M, Cordenonsi M, Wessely O , Dupont S, Piccolo S ., Cell Death Differ. October 1, 2012; 19 (10): 1689-97.
Mutations of the serine protease CAP1/ Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity. , Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E., Am J Pathol. August 1, 2012; 181 (2): 605-15.
hnRNP K post-transcriptionally co-regulates multiple cytoskeletal genes needed for axonogenesis. , Liu Y , Szaro BG ., Development. July 1, 2011; 138 (14): 3079-90.
PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. , McCoy KL, Traynelis SF, Hepler JR., Mol Pharmacol. June 1, 2010; 77 (6): 1005-15.
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. , Yuan H, Vance KM, Junge CE, Geballe MT, Snyder JP, Hepler JR, Yepes M, Low CM, Traynelis SF., J Biol Chem. May 8, 2009; 284 (19): 12862-73.
PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC. , Ossipova O, Tabler J, Green JB , Sokol SY ., Development. December 1, 2007; 134 (23): 4297-306.
Indirect activation of the epithelial Na+ channel by trypsin. , Bengrine A, Li J, Hamm LL, Awayda MS., J Biol Chem. September 14, 2007; 282 (37): 26884-26896.
Apical-basal polarity, Wnt signaling and vertebrate organogenesis. , Karner C, Wharton KA, Carroll TJ ., Semin Cell Dev Biol. April 1, 2006; 17 (2): 214-22.
Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region. , Park SH, Shin YK , Suh YH, Park WS, Ban YL, Choi HS, Park HJ, Jung KC., Gene. July 4, 2005; 353 (2): 177-88.
Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. , Waxman JS, Hocking AM, Stoick CL, Moon RT ., Development. December 1, 2004; 131 (23): 5909-21.
Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. , Xia XM, Ding JP, Lingle CJ., J Gen Physiol. February 1, 2003; 121 (2): 125-48.
Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis. , Ossipova O, He X , Green J ., Mech Dev. December 1, 2002; 119 Suppl 1 S143-8.
Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. , Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM, Reynolds EE, Oksenberg D., Mol Pharmacol. December 1, 2000; 58 (6): 1178-87.
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. , Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS., J Biol Chem. August 25, 2000; 275 (34): 26333-42.
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. , Camerer E, Huang W, Coughlin SR., Proc Natl Acad Sci U S A. May 9, 2000; 97 (10): 5255-60.
Cathepsin G activates protease-activated receptor-4 in human platelets. , Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR., J Biol Chem. March 10, 2000; 275 (10): 6819-23.
A dual thrombin receptor system for platelet activation. , Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR., Nature. August 13, 1998; 394 (6694): 690-4.
Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. , Hollenberg MD, Saifeddine M, al-Ani B, Kawabata A., Can J Physiol Pharmacol. July 1, 1997; 75 (7): 832-41.
Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin ( PAR1) or trypsin (PAR2). , Kawabata A, Saifeddine M, al-Ani B, Hollenberg MD., Proc West Pharmacol Soc. January 1, 1997; 40 49-51.
Ligand cross-reactivity within the protease-activated receptor family. , Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J, Scarborough RM., J Biol Chem. July 12, 1996; 271 (28): 16466-71.