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XB-GENEPAGE-482010
rab5a RAB5A, member RAS oncogene family
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| abnormal tracheoesophageal septum (2 sources), abnormal esophagus morphology (1 source), abnormally localised mitotic spindle (1 source), abnormal trachea morphology (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: rab5a manipulated (3 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| esophageal atresia/tracheoesophageal fistula (2AP sources, 1 EP source), esophageal atresia (1AP source) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xtr Wt + rab5a CRISPR (4 sources) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (8 sources): abnormal circulating triglyceride level, abnormal grip strength, abnormal sleep behavior, decreased anxiety-related response, decreased grip strength, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, increased erythrocyte cell number |