| Monarch Ortholog Phenotypes
|
Human (48 sources):
Abnormal corpus callosum morphology,
Abnormal involuntary eye movements,
Abnormal myelination,
Abnormality of coordination,
Abnormality of vision,
Ataxia,
Attention deficit hyperactivity disorder,
Autism,
Behavioral abnormality,
Brain atrophy,
Cerebral atrophy,
Decreased fetal movement,
Delayed speech and language development,
Developmental regression,
Difficulty walking,
Downslanted palpebral fissures,
Dyskinesia,
EEG with multifocal slow activity,
Encephalopathy,
Failure to thrive,
Feeding difficulties,
Gastroesophageal reflux,
Generalized hypotonia,
Global developmental delay,
High forehead,
Hypodontia,
Hyporeflexia,
Hypsarrhythmia,
Impulsivity,
Intellectual disability,
Involuntary movements,
Limb hypertonia,
Mental deterioration,
Microcephaly,
Myoclonus,
Nystagmus,
Optic atrophy,
Poor head control,
Ptosis,
Reduced tendon reflexes,
Retinal degeneration,
Rigidity,
Seizure,
Short stature,
Spasticity,
Status epilepticus,
Tremor,
Unsteady gait
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|
Mouse (23 sources):
abnormal CNS synaptic transmission,
abnormal GABA-mediated receptor currents,
abnormal conditioned emotional response,
abnormal locomotor behavior,
abnormal miniature inhibitory postsynaptic currents,
decreased chemically-elicited antinociception,
decreased large unstained cell number,
decreased locomotor activity,
decreased physiological sensitivity to xenobiotic,
decreased survivor rate,
enhanced behavioral response to anesthetic,
enhanced contextual conditioning behavior,
enhanced cued conditioning behavior,
homeostasis/metabolism phenotype,
impaired behavioral response to xenobiotic,
increased anxiety-related response,
increased grip strength,
increased thigmotaxis,
limb grasping,
postnatal lethality,
postnatal lethality, incomplete penetrance,
prolonged RR interval,
trunk curl
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.