atg16l1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-1011169

Gene Symbol: atg16l1 Gene Name: autophagy related 16 like 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: atg16l1 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (42 sources): abnormal Paneth cell morphology, abnormal autophagosome formation, abnormal autophagy, abnormal chemokine level, abnormal circulating interleukin level, abnormal cytokine level, abnormal enterocyte morphology, abnormal enterocyte physiology, abnormal eye muscle morphology, abnormal hepatic vein morphology, abnormal hypoglossal nerve topology, abnormal inferior vena cava valve morphology, abnormal intrathoracic topology of vagus nerve, abnormal macrophage physiology, abnormal thymus topology, abnormal vitelline vein topology, absent connection between subcutaneous lymph vessels and lymph sac, absent ductus venosus valve, absent hypoglossal nerve, absent segment of posterior cerebral artery, blood in lymph vessels, cecum inflammation, cellular phenotype, decreased Paneth cell number, digestive/alimentary phenotype, immune system phenotype, impaired autophagy, increased circulating interleukin-1 beta level, increased circulating interleukin-6 level, increased enterocyte apoptosis, increased interleukin-1 beta secretion, increased interleukin-18 secretion, increased macrophage cell number, increased macrophage cytokine production, increased mean corpuscular hemoglobin, increased susceptibility to induced colitis, neonatal lethality, complete penetrance, prenatal lethality, preweaning lethality, complete penetrance, small intestinal inflammation, subcutaneous edema, thoracoschisis [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (42 sources): abnormal Paneth cell morphology, abnormal autophagosome formation, abnormal autophagy, abnormal chemokine level, abnormal circulating interleukin level, abnormal cytokine level, abnormal enterocyte morphology, abnormal enterocyte physiology, abnormal eye muscle morphology, abnormal hepatic vein morphology, [+]