| Monarch Ortholog Phenotypes
|
Human (24 sources):
Abnormality of movement,
Astigmatism,
Ataxia,
Esotropia,
Exaggerated startle response,
Fasciculations,
Gait disturbance,
Gastroesophageal reflux,
Glabellar reflex,
Hernia,
Hiatus hernia,
Hip dislocation,
Hyperreflexia,
Intellectual disability,
Joint dislocation,
Joint stiffness,
Muscle stiffness,
Myoclonus,
Myopia,
Rigidity,
Seizure,
Sleep disturbance,
Spasticity,
Umbilical hernia
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Mouse (25 sources):
abnormal Purkinje cell morphology,
abnormal adrenal cortex morphology,
abnormal brain dura mater morphology,
abnormal dorsal root ganglion morphology,
abnormal intervertebral disk morphology,
abnormal maternal nurturing,
abnormal motor capabilities/coordination/movement,
abnormal spinal cord ventral horn morphology,
abnormal spinal nerve morphology,
abnormal vertebral column morphology,
decreased body size,
decreased circulating alkaline phosphatase level,
decreased freezing behavior,
decreased startle reflex,
impaired acrosome reaction,
impaired fertilization,
impaired righting response,
impaired swimming,
increased startle reflex,
limb grasping,
muscle hypertonia,
postnatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
reduced male fertility,
short stride length
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.