aldh1a2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1012908

Gene Symbol: aldh1a2 Gene Name: aldehyde dehydrogenase 1 family member A2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally anteriorly mislocalised eye (4 sources), abnormally incomplete structure of head (4 sources), absent eye (4 sources), decreased length of anterior-posterior axis (4 sources), fused eyes (4 sources), abnormal mouth morphology (2 sources), abnormal roof of mouth morphology (2 sources), abnormal craniofacial region morphology (1 source), abnormal development of eye (1 source), abnormal eye morphology (1 source), abnormal head morphology (1 source), abnormally decreased volume of oral cavity (1 source), decreased size of the head (1 source), decreased size of the head mesenchyme (1 source), decreased size of the intercanthal region (1 source), decreased size of the mouth (1 source), decreased width of the head (1 source), decreased width of the mouth (1 source), increased pigmentation in the head (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally anteriorly mislocalised eye (4 sources), abnormally incomplete structure of head (4 sources), absent eye (4 sources), decreased length of anterior-posterior axis (4 sources), fused eyes (4 sources), abnormal mouth morphology (2 sources), abnormal roof of mouth morphology (2 sources), abnormal craniofacial region morphology (1 source), abnormal development of eye (1 source), abnormal eye morphology (1 source), abnormal head morphology (1 source), abnormally decreased volume of oral cavity (1 source), decreased size of the head (1 source), decreased size of the head mesenchyme (1 source), decreased size of the intercanthal region (1 source), decreased size of the mouth (1 source), decreased width of the head (1 source), decreased width of the mouth (1 source), increased pigmentation in the head (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: aldh1a2 manipulated (3 sources), aldh1a2 assayed (19 sources)
Computed annotations: aldh1a2 assayed (9 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
microcephaly (1AP source), orofacial cleft (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + aldh1a2 MO (3 sources), Xla Wt + aldh1a2 CRISPR (2 sources), Xla Wt + aldh1a2 MO (1 source), Xla Wt + aldh1a2 MO + rdh10 MO (1 source), Xla Wt + aldh1a2 + retinol (1 source), Xla Wt + aldh1a2 + retinol (1 source), Xla Wt + aldh1a2 + sdr16c5 + retinol (1 source), Xla Wt + aldh1a2 + sdr16c5 + retinol (1 source), Xla Wt + cyp26a1 + aldh1a2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (1 source): Ischemic stroke
Mouse (75 sources): aberrant origin of the right subclavian artery, abnormal aortic arch and aortic arch branch attachment, abnormal artery morphology, abnormal common carotid artery morphology, abnormal embryonic tissue morphology, abnormal embryo turning, abnormal fetal atrioventricular canal morphology, abnormal fetal cardiomyocyte morphology, abnormal first pharyngeal arch morphology, abnormal glossopharyngeal ganglion morphology, abnormal heart development, abnormal heart tube morphology, abnormal laryngeal cartilage morphology, abnormal left subclavian artery morphology, abnormal mandibular prominence morphology, abnormal maxillary prominence morphology, abnormal motor neuron innervation pattern, abnormal myocardium layer morphology, abnormal nervous system development, abnormal neural crest cell migration, abnormal otic vesicle morphology, abnormal pharyngeal arch artery morphology, abnormal pharyngeal pouch morphology, abnormal somite development, abnormal third pharyngeal arch artery morphology, abnormal thyroid cartilage morphology, abnormal tracheal cartilage morphology, abnormal trigeminal ganglion morphology, abnormal truncus arteriosus septation, abnormal vagus ganglion morphology, abnormal vascular development, abnormal vestibulocochlear ganglion morphology, abnormal vitamin A level, abnormal vitelline vasculature morphology, absent atrioventricular cushions, absent forelimb buds, absent fourth pharyngeal arch, absent hindlimb buds, absent myocardial trabeculae, absent parathyroid glands, absent pharyngeal arch arteries, absent pharyngeal arches, absent second pharyngeal arch, absent third pharyngeal arch, absent Wolffian ducts, caudal body truncation, conotruncal ridge hypoplasia, decreased body length, decreased body size, decreased embryo size, decreased motor neuron number, decreased somite size, decreased tracheal cartilage ring number, embryonic growth arrest, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, failure of heart looping, failure of ventral body wall closure, fusion of glossopharyngeal and vagus nerve, impaired branching involved in ureteric bud morphogenesis, incomplete caudal neuropore closure, limbs/digits/tail phenotype, muscle phenotype, no abnormal phenotype detected, otic vesicle hypoplasia, pharyngeal arch hypoplasia, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, short trachea, skeleton phenotype, small first pharyngeal arch, small forelimb buds, small frontonasal prominence, small otic vesicle, thick myocardium [+]
View all ortholog results at Monarch