cul4a Phenotypes

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Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (40 sources): abnormal DNA replication, abnormal cell cycle checkpoint function, abnormal centrosome morphology, abnormal definitive hematopoiesis, abnormal double-strand DNA break repair, abnormal enterocyte morphology, abnormal male germ cell apoptosis, abnormal male meiosis, abnormal small intestine crypts of Lieberkuhn morphology, abnormal sperm flagellum morphology, abnormal sperm head morphology, abnormal spermatid morphology, abnormal spermatocyte morphology, abnormal spleen capsule morphology, asthenozoospermia, chromosomal instability, decreased bone marrow cell number, decreased effector memory T-helper cell number, decreased fibroblast proliferation, decreased hematocrit, decreased hematopoietic stem cell number, decreased hepatocyte proliferation, decreased incidence of tumors by UV induction, decreased litter size, decreased spleen red pulp amount, decreased spleen weight, decreased spleen white pulp amount, decreased testis weight, impaired hematopoiesis, increased cellular sensitivity to ultraviolet irradiation, increased enterocyte apoptosis, increased erythrocyte cell number, increased fasting circulating glucose level, increased susceptibility to injury, multinucleated giant male germ cells, premature death, reduced female fertility, reproductive system phenotype, small epididymis, small thymus [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (40 sources): abnormal DNA replication, abnormal cell cycle checkpoint function, abnormal centrosome morphology, abnormal definitive hematopoiesis, abnormal double-strand DNA break repair, abnormal enterocyte morphology, abnormal male germ cell apoptosis, abnormal male meiosis, abnormal small intestine crypts of Lieberkuhn morphology, abnormal sperm flagellum morphology, [+]