| Monarch Ortholog Phenotypes
|
|
Human (16 sources):
Absent thumb,
Aplasia/Hypoplasia of the radius,
Cryptorchidism,
Delayed skeletal maturation,
Fibular hypoplasia,
Hypoplasia of the ulna,
Intellectual disability,
Microcephaly,
Micropenis,
Narrow mouth,
[+]
|
Mouse (40 sources):
abnormal DNA methylation,
abnormal bone marrow cell physiology,
abnormal epigenetic regulation of gene expression,
abnormal forelimb morphology,
abnormal hindlimb morphology,
abnormal hindlimb zeugopod morphology,
abnormal limb morphology,
abnormal male germ cell apoptosis,
abnormal patella morphology,
abnormal spermatogonia morphology,
abnormal spermatogonia proliferation,
abnormal talus morphology,
abnormal tarsal bone morphology,
abnormal xiphoid process morphology,
asthenozoospermia,
bowed fibula,
decreased CD4-positive, alpha beta T cell number,
decreased NK T cell number,
decreased caudal vertebrae number,
decreased male germ cell number,
ectopic digits,
hematopoietic system phenotype,
hemimelia,
increased CD4-positive, alpha-beta memory T cell number,
increased T-helper 2 cell number,
increased presacral vertebrae number,
increased sternebra number,
increased thoracic vertebrae number,
interdigital webbing,
kinked tail,
lumbar vertebral transformation,
polyphalangy,
reduced male fertility,
reproductive system phenotype,
sacral vertebral transformation,
seminiferous tubule degeneration,
short tail,
thoracic vertebral transformation,
vertebral transformation,
xiphoid process foramen
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.