eomes Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (118)

Nucleotides (155)

Interactants (1207)

XB-GENEPAGE-479768

Gene Symbol: eomes Gene Name: eomesodermin

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: eomes assayed (7 sources)
Computed annotations: eomes manipulated (5 sources), eomes assayed (31 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + vegt MO + eomes MO + tbxt MO + tbxt.2 MO (3 sources), Xtr Wt + eomes + animal cap explant (1 source), Xtr Wt + foxb1 + eomes + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (7 sources): Agenesis of corpus callosum, Cerebellar hypoplasia, Polymicrogyria, Primary microcephaly, Recurrent infections, Respiratory distress, Ventriculomegaly
Mouse (45 sources): abnormal anterior primitive streak morphology, abnormal axon guidance, abnormal dentate gyrus morphology, abnormal egg cylinder morphology, abnormal embryonic epiblast morphology, abnormal leukocyte migration, abnormal neuronal precursor proliferation, abnormal neuron apoptosis, abnormal primitive streak elongation, abnormal primitive streak morphology, abnormal retina ganglion cell morphology, abnormal trophoblast layer morphology, absent anterior commissure, absent mesoderm, absent primitive node, absent trophectoderm, absent trophoblast giant cells, decreased bone mineral content, decreased brain size, decreased grip strength, decreased lean body mass, decreased memory T cell number, decreased red blood cell distribution width, decreased retina ganglion cell number, embryonic growth arrest, embryonic lethality before implantation, complete penetrance, embryonic lethality between implantation and placentation, embryonic lethality between implantation and placentation, complete penetrance, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, embryo phenotype, failure of embryo implantation, failure to gastrulate, immune system phenotype, increased aggression towards humans, increased aggression towards mice, increased retina apoptosis, increased total body fat amount, increased tumor incidence, no abnormal phenotype detected, preweaning lethality, complete penetrance, small olfactory bulb, thin cerebral cortex, thin retina ganglion layer [+]
View all ortholog results at Monarch