Areflexia, Areflexia of lower limbs, Arthralgia, Axonal degeneration/regeneration, Babinski sign, Central scotoma, Color vision defect, Decreased motor nerve conduction velocity, Decreased number of peripheral myelinated nerve fibers, Delayed gross motor development, Difficulty climbing stairs, Difficulty running, Difficulty walking, Distal amyotrophy, Distal lower limb amyotrophy, Distal lower limb muscle weakness, Distal muscle weakness, Distal sensory impairment, Distal sensory impairment of all modalities, Dysmetric saccades, Dysphonia, EMG: chronic denervation signs, Flexion contracture, Foot dorsiflexor weakness, Foot pain, Frequent falls, Gait disturbance, Hammertoe, Hand muscle weakness, Hand tremor, Hearing impairment, Hepatomegaly, Hoarse voice, Hydrocephalus, Hyperreflexia, Hyporeflexia, Impaired pain sensation, Impaired temperature sensation, Impaired vibratory sensation, Inability to walk by childhood/adolescence, Increased laxity of ankles, Insulin resistance, Joint stiffness, Kyphosis, Limb muscle weakness, Lipoma, Lower limb pain, Lumbar hyperlordosis, Mental deterioration, Mild neurosensory hearing impairment, Multiple lipomas, Muscle spasm, Nyctalopia, Onion bulb formation, Optic atrophy, Optic disc pallor, Pain, Paresis of extensor muscles of the big toe, Paresthesia, Peripheral axonal atrophy, Peripheral axonal neuropathy, Peripheral neuropathy, Pes cavus, Poor fine motor coordination, Positive Romberg sign, Postural tremor, Proximal muscle weakness, Quadriceps muscle weakness, Reduced tendon reflexes, Respiratory insufficiency due to muscle weakness, Restless legs, Scoliosis, Sensorineural hearing impairment, Sensory axonal neuropathy, Sensory neuropathy, Slow decrease in visual acuity, Somatic sensory dysfunction, Spasticity, Steppage gait, Tinnitus, Tremor, Triceps weakness, Upper limb pain, Vocal cord paralysis, Vocal cord paresis

abnormal mitochondrial physiology, abnormal myocardial fiber morphology, abnormal myocardial fiber physiology, abnormal neuron physiology, abnormal respiratory electron transport chain, abnormal substantia nigra pars compacta morphology, abnormal tail morphology, abnormal trophoblast layer morphology, decreased blood urea nitrogen level, decreased body size, decreased dopamine level, decreased embryo size, decreased locomotor activity, decreased skeletal muscle size, decreased trophoblast giant cell number, decreased ventricle muscle contractility, decreased vertical activity, embryonic lethality during organogenesis, incomplete penetrance, impaired limb coordination, impaired righting response, increased fetal cardiomyocyte apoptosis, increased neuron apoptosis, increased response of heart to induced stress, increased serotonin level, kinked tail, lethality throughout fetal growth and development, complete penetrance, limbs/digits/tail phenotype, lipofuscinosis, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, postnatal lethality, complete penetrance, premature death, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, prolonged ST segment, short tail, small cerebellum