Aplasia/Hypoplasia of the breasts, Constipation, Decreased cervical spine mobility, Decreased circulating ACTH level, Decreased response to growth hormone stimulation test, Decreased testicular size, Delayed puberty, Delayed skeletal maturation, Depressed nasal ridge, Ectopic anterior pituitary gland, Ectopic posterior pituitary, Fatigue, Growth delay, Holoprosencephaly, Hypoglycemia, Hypogonadotropic hypogonadism, Hypopituitarism, Hypotension, Infertility, Median cleft lip and palate, Optic nerve hypoplasia, Osteopenia, Osteoporosis of vertebrae, Pituitary dwarfism, Pituitary hypothyroidism, Polydactyly, Seizure, Septo-optic dysplasia, Severe global developmental delay

abnormal mesendoderm development, abnormal miscarriage rate, abnormal nervous system development, abnormal neuron differentiation, abnormal pancreatic beta cell morphology, abnormal paraxial mesoderm morphology, abnormal primitive endoderm morphology, abnormal primitive streak elongation, abnormal primitive streak formation, abnormal pulmonary alveolus epithelial cell morphology, abnormal pulmonary alveolus wall morphology, abnormal respiratory mechanics, abnormal respiratory mucosa goblet cell morphology, abnormal rostral-caudal axis patterning, abnormal somite development, abnormal somite shape, abnormal surfactant composition, abnormal surfactant secretion, abnormal type II pneumocyte morphology, absent alveolar lamellar bodies, absent estrous cycle, absent estrus, absent floor plate, absent mesoderm, absent notochord, absent primitive node, absent type I pneumocytes, circling, decreased body size, decreased circulating free fatty acids level, decreased circulating glucose level, decreased embryo size, decreased lung compliance, decreased pancreatic alpha cell number, decreased skin turgor, decreased somite size, decreased surfactant secretion, delayed heart development, dilated respiratory conducting tube, disorganized pancreatic islets, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, embryonic-extraembryonic boundary constriction, fused somites, hunched posture, immune system phenotype, impaired lung alveolus development, impaired righting response, improved glucose tolerance, increased airway resistance, increased basal metabolism, increased carbon dioxide production, increased embryonic tissue cell apoptosis, increased fluid intake, increased food intake, increased glycogen level, increased insulin sensitivity, increased lean body mass, increased liver triglyceride level, increased macrophage cell number, increased neutrophil cell number, increased oxygen consumption, increased respiratory mucosa goblet cell number, increased susceptibility to injury, kinked neural tube, long incisors, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, postnatal lethality, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, premature death, pulmonary hyaline membrane formation, pulmonary vascular congestion, pup cannibalization, reduced female fertility, respiratory system inflammation, rostral body truncation