osr1 Phenotypes

Phenotypes

XB-GENEPAGE-481409

Gene Symbol: osr1 Gene Name: odd-skipped related transcription factor 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent lung bud (5 sources), abnormal development of foregut (3 sources), abnormal development of lung (2 sources), abnormal development of esophagus (1 source), abnormal development of trachea (1 source), abnormal foregut morphology (1 source), decreased size of the stomach (1 source), increased apoptosis in embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: osr1 manipulated (30 sources), osr1 assayed (7 sources)
Computed annotations: osr1 assayed (19 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + Mmu.osr1-GR + osr1 MO + osr2 MO (10 sources), Xtr Wt + osr1 MO + osr2 MO (8 sources), Xtr Wt + osr1 MO + osr2 MO (8 sources), Xtr Wt + osr1 MO + osr2 MO + BIO (2 sources), Xtr Wt + osr1 MO + osr2 MO + RA (2 sources), Xtr Wt + Mmu.osr1-GR + DEX (1 source), Xtr Wt + osr1 MO + osr2 MO + BIO + RA (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (29 sources): abnormal Wolffian duct morphology, abnormal epicardium morphology, abnormal fetal atrioventricular canal morphology, abnormal forelimb bud morphology, abnormal kidney development, abnormal mesonephric mesenchyme morphology, abnormal mesonephros morphology, abnormal metanephric mesenchyme morphology, abnormal nephrogenic mesenchyme morphogenesis, abnormal pericardium morphology, abnormal survival, absent adrenal gland, absent metanephric mesenchyme, absent metanephros, absent testes, absent ureteric bud, absent vitelline blood vessels, agonadal, dilated heart atrium, embryonic growth arrest, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, gonadal ridge hypoplasia, increased kidney apoptosis, increased metanephric mesenchyme apoptosis, lethality throughout fetal growth and development, complete penetrance, no abnormal phenotype detected, rudimentary Wolffian ducts, skeleton phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (29 sources): abnormal Wolffian duct morphology, abnormal epicardium morphology, abnormal fetal atrioventricular canal morphology, abnormal forelimb bud morphology, abnormal kidney development, abnormal mesonephric mesenchyme morphology, abnormal mesonephros morphology, abnormal metanephric mesenchyme morphology, abnormal nephrogenic mesenchyme morphogenesis, abnormal pericardium morphology, [+]