crim1 Phenotypes

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Phenotypes

Gene Literature (7)

Nucleotides (53)

Interactants (307)

XB-GENEPAGE-481451

Gene Symbol: crim1 Gene Name: cysteine rich transmembrane BMP regulator 1 (chordin-like)

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent eye (2 sources), absent neural tube (2 sources), abnormal cell adhesion (1 source), abnormal neural plate morphology (1 source), abnormal neural tube closure (1 source), abnormally open neural tube (1 source), absent anterior neural tube (1 source), absent brain (1 source), absent central nervous system (1 source), decreased size of the eye (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: crim1 manipulated (2 sources)
Computed annotations: crim1 assayed (11 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + crim1 MO (7 sources), Xla Wt + crim1 MO (2 sources), Xla Wt + crim1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (8 sources): Coloboma, Macular atrophy, Microcornea, Myopia, Nystagmus, Ocular hypertension, Reduced visual acuity, Strabismus
Mouse (77 sources): abnormal Meckel's cartilage morphology, abnormal Mullerian duct topology, abnormal basal lamina morphology, abnormal ductus venosus valve morphology, abnormal eye posterior chamber morphology, abnormal glomerular capillary endothelium morphology, abnormal glomerular capillary morphology, abnormal glomerular filtration barrier function, abnormal hepatic portal vein connection, abnormal hypoglossal nerve topology, abnormal kidney corticomedullary boundary morphology, abnormal kidney pelvis morphology, abnormal optic cup morphology, abnormal peritubular capillary endothelium morphology, abnormal peritubular capillary morphology, abnormal podocyte foot process morphology, abnormal podocyte morphology, abnormal renal filtration rate, abnormal renal glomerulus basement membrane morphology, abnormal renal glomerulus morphology, abnormal renin activity, abnormal vertebral arch morphology, abnormal vertebral artery topology, abnormal vitelline vein connection, abnormal vitelline vein topology, absent connection between subcutaneous lymph vessels and lymph sac, absent ductus venosus, absent ductus venosus valve, absent glomerular endothelium fenestra, absent mandibular nerve, absent posterior communicating artery, absent segment of posterior cerebral artery, anastomosis between internal carotid artery and basilar artery, aortic arch coarctation, bleb, blood in lymph vessels, cardiovascular system phenotype, cortical renal glomerulopathies, decreased parotid gland size, decreased podocyte number, decreased renal glomerular filtration rate, decreased renal glomerulus basement membrane thickness, decreased survivor rate, dilated glomerular capillary, dilated renal tubules, dislocated lens, fetal bleb, fragmented Meckel's cartilage, fused dorsal root ganglion, fusion of vertebral arches, glomerulus hemorrhage, growth/size/body region phenotype, hematoma, hematopoietic system phenotype, herniated liver, impaired ureteric peristalsis, increased glomerular capsule space, increased kidney apoptosis, increased renal glomerulus basement membrane thickness, increased vascular permeability, kidney papillary atrophy, kidney papillary hypoplasia, lethality, incomplete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, podocyte foot process effacement, postnatal lethality, complete penetrance, preweaning lethality, complete penetrance, renal glomerulus cysts, renal glomerulus hypertrophy, renal/urinary system phenotype, retrolental blood, short kidney papilla, small kidney, subcutaneous edema, trunk curl [+]
View all ortholog results at Monarch