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Summary Expression Phenotypes Gene Literature (7) GO Terms (5) Nucleotides (53) Proteins (24) Interactants (307) Wiki

crim1     cysteine rich transmembrane BMP regulator 1 (chordin-like)

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent eye (2 sources), absent neural tube (2 sources), abnormal cell adhesion (1 source), abnormal neural plate morphology (1 source), abnormal neural tube closure (1 source), abnormally open neural tube (1 source), absent anterior neural tube (1 source), absent brain (1 source), absent central nervous system (1 source), decreased size of the eye (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: crim1 manipulated (2 sources)
Computed annotations: crim1 assayed (11 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + crim1 MO (7 sources), Xla Wt + crim1 MO (2 sources), Xla Wt + crim1 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (8 sources): Coloboma, Macular atrophy, Microcornea, Myopia, Nystagmus, Ocular hypertension, Reduced visual acuity, Strabismus
Mouse (77 sources): abnormal Meckel's cartilage morphology, abnormal Mullerian duct topology, abnormal basal lamina morphology, abnormal ductus venosus valve morphology, abnormal eye posterior chamber morphology, abnormal glomerular capillary endothelium morphology, abnormal glomerular capillary morphology, abnormal glomerular filtration barrier function, abnormal hepatic portal vein connection, abnormal hypoglossal nerve topology, [+]

View all ortholog results at Monarch