e2f1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-481740

Gene Symbol: e2f1 Gene Name: E2F transcription factor 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: e2f1 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (55 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha beta T cell morphology, abnormal base-excision repair, abnormal cell death, abnormal cone electrophysiology, abnormal double-positive T cell morphology, abnormal double-strand DNA break repair, abnormal exocrine pancreas morphology, abnormal exorbital lacrimal gland morphology, abnormal fat cell differentiation, abnormal gland morphology, abnormal pancreatic beta cell morphology, abnormal pancreatic islet morphology, abnormal parotid gland morphology, abnormal retina bipolar cell morphology, abnormal retina progenitor cell morphology, abnormal submandibular gland morphology, cellular phenotype, decreased T cell proliferation, decreased apoptosis, decreased circulating glucose level, decreased double-positive T cell number, decreased insulin secretion, decreased pancreas weight, decreased pancreatic islet number, decreased regulatory T cell number, decreased retina ganglion cell number, decreased salivation, decreased testis weight, endocrine/exocrine gland phenotype, enlarged thymus, hearing/vestibular/ear phenotype, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased T cell derived lymphoma incidence, increased adipocyte glucose uptake, increased histiocytic sarcoma incidence, increased incidence of tumors by UV-induction, increased insulin sensitivity, increased interferon-gamma secretion, increased interleukin-4 secretion, increased lymphoma incidence, increased metastatic potential, increased reproductive system tumor incidence, increased sensitivity to skin irradiation, increased susceptibility to autoimmune diabetes, increased thymocyte number, increased thymus weight, increased tumor incidence, insulitis, premature death, salivary gland inflammation, seminiferous tubule degeneration, small pancreatic islets, thin retina outer nuclear layer [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (55 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha beta T cell morphology, abnormal base-excision repair, abnormal cell death, abnormal cone electrophysiology, abnormal double-positive T cell morphology, abnormal double-strand DNA break repair, abnormal exocrine pancreas morphology, abnormal exorbital lacrimal gland morphology, abnormal fat cell differentiation, [+]