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Summary Expression Phenotypes Gene Literature (41) GO Terms (78) Nucleotides (368) Proteins (48) Interactants (576) Wiki
XB-GENEPAGE-482010

rab5a     RAB5A, member RAS oncogene family

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal tracheoesophageal septum (2 sources), abnormal esophagus morphology (1 source), abnormally localised mitotic spindle (1 source), abnormal trachea morphology (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rab5a manipulated (3 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
esophageal atresia/tracheoesophageal fistula (2AP sources, 1 EP source), esophageal atresia (1AP source)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + rab5a CRISPR (4 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (8 sources): abnormal circulating triglyceride level, abnormal grip strength, abnormal sleep behavior, decreased anxiety-related response, decreased grip strength, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, increased erythrocyte cell number