Decreased body weight, Deep palmar crease, Deep plantar creases, Deeply set eye, Delayed speech and language development, Everted lower lip vermilion, Failure to thrive, Feeding difficulties, Full cheeks, Global developmental delay, Hearing impairment, High anterior hairline, High forehead, Hypertelorism, Hypoplastic areola, Hypotonia, Intellectual disability, Large fleshy ears, Long upper lip, Malar flattening, Microcephaly, Microcornea, Micropenis, Microphthalmia, Midface retrusion, Narrow palpebral fissure, Pendular nystagmus, Posteriorly rotated ears, Prominent fingertip pads, Prominent median palatal raphe, Prominent subcalcaneal fat pad, Scoliosis, Seizure, Short finger, Short foot, Short neck, Short nose, Short palm, Short stature, Short toe, Smooth philtrum, Spasticity, Strabismus, Telecanthus, Thin vermilion border, Unilateral narrow palpebral fissure, Wide intermamillary distance, Wide nose, Widely spaced teeth

increased susceptibility to diet-induced obesity, increased total body fat amount, increased triglyceride level, increased white fat cell number, increased white fat cell size, preweaning lethality, incomplete penetrance