| Monarch Ortholog Phenotypes
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Human (47 sources):
Abnormal cardiovascular system morphology,
Abnormal facial shape,
Agenesis of corpus callosum,
Ambiguous genitalia,
Anteverted nares,
Asthma,
Broad forehead,
Choanal atresia,
Cleft palate,
Cyclopia,
Depressed nasal bridge,
Duodenal atresia,
EMG: myopathic abnormalities,
Global developmental delay,
Hemangioma,
High palate,
Holoprosencephaly,
Hydrocephalus,
Hypertelorism,
Hypoplasia of penis,
Hypotelorism,
Hypothyroidism,
Intellectual disability,
Intrauterine growth retardation,
Iris coloboma,
Macrotia,
Maternal diabetes,
Microcephaly,
Midnasal stenosis,
Narrow forehead,
Narrow nasal bridge,
Orofacial cleft,
Panhypopituitarism,
Premature birth,
Renal agenesis,
Scoliosis,
Seizure,
Short nose,
Short philtrum,
Short stature,
Solitary median maxillary central incisor,
Strabismus,
Synophrys,
Tented upper lip vermilion,
Tetralogy of Fallot,
Trigonocephaly,
Upslanted palpebral fissure
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Mouse (57 sources):
abnormal amygdala morphology,
abnormal brain development,
abnormal cerebral cortex morphology,
abnormal cerebral hemisphere morphology,
abnormal dorsal root ganglion morphology,
abnormal enteric neural crest cell morphology,
abnormal enteric neuron morphology,
abnormal eye distance/ position,
abnormal forebrain development,
abnormal hepatic vein connection,
abnormal intestine physiology,
abnormal nervous system development,
abnormal neural fold formation,
abnormal neural plate morphology,
abnormal neurite morphology,
abnormal notochord morphology,
abnormal prechordal plate morphology,
abnormal primitive node morphology,
abnormal roof plate morphology,
abnormal spatial learning,
abnormal spatial working memory,
abnormal spinal cord dorsal horn morphology,
abnormal spleen size,
abnormal telencephalon development,
abnormal vertebral arch morphology,
behavior/neurological phenotype,
belly spot,
curly tail,
decreased aggression towards mice,
decreased brain size,
decreased corpus callosum size,
decreased locomotor activity,
decreased neural crest cell number,
decreased neuron number,
decreased prepulse inhibition,
decreased rhombomere 3 size,
decreased rhombomere 5 size,
delayed caudal neuropore closure,
embryonic lethality during organogenesis, complete penetrance,
enlarged lateral ventricles,
fusion of vertebral arches,
hematoma,
hindlimb paralysis,
impaired contextual conditioning behavior,
impaired cued conditioning behavior,
incomplete rostral neuropore closure,
increased ectoderm apoptosis,
increased startle reflex,
kinked tail,
left sided inferior vena cava,
perinatal lethality, complete penetrance,
postnatal lethality, complete penetrance,
right pulmonary isomerism,
right-sided isomerism,
right-sided stomach,
rostral body truncation,
thin cerebral cortex
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.