Accelerated skeletal maturation, Aplasia/Hypoplasia of the skin, Arrhythmia, Arterial stenosis, Atherosclerosis, Atlantoaxial dislocation, Atrial fibrillation, Bone cyst, Bradycardia, Broad foot, Calf muscle pseudohypertrophy, Cirrhosis, Congestive heart failure, Coronary artery atherosclerosis, Decreased HDL cholesterol concentration, Decreased circulating IgA level, Decreased response to growth hormone stimulation test, Decreased resting energy expenditure, Delayed skeletal maturation, Diabetes mellitus, Dysmenorrhea, Eclampsia, Elevated circulating growth hormone concentration, Elevated circulating hepatic transaminase concentration, Exercise-induced myalgia, Failure to thrive, Flexion contracture, Generalized hirsutism, Glomerulopathy, Hepatic failure, Hepatic steatosis, Hepatomegaly, Hirsutism, Hyperglycemia, Hyperhidrosis, Hyperinsulinemia, Hyperlordosis, Hypertension, Hypertriglyceridemia, Hypertrophic cardiomyopathy, Hyperuricemia, Immunodeficiency, Increased waist to hip ratio, Insulin resistance, Insulin-resistant diabetes mellitus, Intellectual disability, Large hands, Lipoatrophy, Lipodystrophy, Loss of facial adipose tissue, Loss of gluteal subcutaneous adipose tissue, Loss of subcutaneous adipose tissue in limbs, Mandibular prognathia, Marked muscular hypertrophy, Maternal diabetes, Muscle stiffness, Muscle weakness, Myalgia, Myocardial infarction, Myopathy, Nephropathy, Obesity, Oligomenorrhea, Osteopenia, Osteoporosis, Palpitations, Pancreatitis, Peripheral neuropathy, Polycystic ovaries, Precocious puberty, Preeclampsia, Primary amenorrhea, Progressive proximal muscle weakness, Prolonged QTc interval, Prominent superficial veins, Prominent supraorbital ridges, Prominent veins on trunk, Pulmonary arterial hypertension, Pyloric stenosis, Recurrent fractures, Recurrent infections, Reduced subcutaneous adipose tissue, Renal insufficiency, Scoliosis, Secondary amenorrhea, Skeletal muscle hypertrophy, Spinal rigidity, Splenomegaly, Thickened skin, Thin skin, Ventricular hypertrophy, Ventriculomegaly, Xanthomatosis

abnormal brown fat cell size, abnormal cell differentiation, abnormal chorionic plate morphology, abnormal circadian temperature homeostasis, abnormal circulating alanine transaminase level, abnormal circulating aldosterone level, abnormal coat appearance, abnormal diestrus, abnormal endocrine pancreas morphology, abnormal epididymal fat pad morphology, abnormal fat cell differentiation, abnormal fat cell morphology, abnormal fetal cardiomyocyte morphology, abnormal gonadal fat pad morphology, abnormal hair cycle, abnormal hair cycle anagen phase, abnormal hair follicle morphology, abnormal hair follicle ostium morphology, abnormal hair shedding, abnormal heart development, abnormal hematocrit, abnormal hepatocyte morphology, abnormal humoral immune response, abnormal inguinal fat pad morphology, abnormal interscapular fat pad morphology, abnormal keratinocyte morphology, abnormal kidney morphology, abnormal lipid homeostasis, abnormal macrophage activation involved in immune response, abnormal macrophage physiology, abnormal mammary gland alveolus morphology, abnormal mammary gland growth during pregnancy, abnormal myocardial fiber morphology, abnormal nephron morphology, abnormal osteoblast differentiation, abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal pancreatic islet morphology, abnormal peritoneal macrophage morphology, abnormal physiological response to xenobiotic, abnormal placenta development, abnormal placenta hemotrichorial membrane morphology, abnormal placenta labyrinth morphology, abnormal placenta morphology, abnormal placental labyrinth vasculature morphology, abnormal podocyte foot process morphology, abnormal renal glomerulus morphology, abnormal renal sodium ion transport, abnormal response to injury, abnormal retina vasculature morphology, abnormal skin appearance, abnormal skin sebaceous gland morphology, abnormal splenocyte morphology, abnormal triglyceride level, abnormal trophoblast giant cell morphology, abnormal trophoblast layer morphology, abnormal vascular endothelial cell physiology, abnormal vasodilation, abnormal white adipose tissue amount, abnormal white adipose tissue morphology, abnormal white adipose tissue physiology, abnormal white fat cell morphology, abnormal white fat cell size, adipose tissue phenotype, cardiac hypertrophy, decreased body fat mass, decreased body mass index, decreased bone marrow cell number, decreased brown adipose tissue amount, decreased brown adipose tissue mass, decreased brown fat cell lipid droplet size, decreased brown fat cell number, decreased brown fat lipid droplet number, decreased circulating adiponectin level, decreased circulating free fatty acids level, decreased embryo size, decreased epididymal fat pad weight, decreased fat cell size, decreased food intake, decreased gonadal fat pad weight, decreased hematocrit, decreased inguinal fat pad weight, decreased interscapular fat pad weight, decreased litter size, decreased muscle cell glucose uptake, decreased osteoclast cell number, decreased percent body fat/body weight, decreased retroperitoneal fat pad weight, decreased susceptibility to diet-induced obesity, decreased susceptibility to hepatic steatosis, decreased systemic arterial blood pressure, decreased total fat pad weight, decreased white adipose tissue amount, decreased white adipose tissue mass, decreased white fat cell number, decreased white fat cell size, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality, complete penetrance, enlarged myocardial fiber, excessive scratching, extended life span, flaky skin, fused podocyte foot processes, growth/size/body region phenotype, hematopoietic system phenotype, homeostasis/metabolism phenotype, immune system phenotype, impaired macrophage phagocytosis, improved glucose tolerance, increased B cell proliferation, increased adipocyte glucose uptake, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased anti-single stranded DNA antibody level, increased autoantibody level, increased body temperature, increased bone trabecula number, increased bone volume, increased brown fat cell lipid droplet size, increased brown fat cell size, increased circulating adiponectin level, increased circulating aspartate transaminase level, increased circulating creatine level, increased circulating glucose level, increased fluid intake, increased incidence of tumors by chemical induction, increased insulin sensitivity, increased interferon-gamma secretion, increased interleukin-2 secretion, increased interscapular fat pad weight, increased kidney weight, increased liver triglyceride level, increased liver weight, increased luteinizing hormone level, increased mean systemic arterial blood pressure, increased mesangial cell number, increased osteoblast cell number, increased renal glomerulus apoptosis, increased renal glomerulus basement membrane thickness, increased right ventricle systolic pressure, increased sensitivity to xenobiotic induced morbidity/mortality, increased splenocyte number, increased susceptibility to experimental autoimmune encephalomyelitis, increased susceptibility to induced arthritis, increased systemic arterial blood pressure, increased trabecular bone mass, increased trabecular bone thickness, increased trabecular bone volume, increased triglyceride level, increased white fat cell size, leukostasis, liver/biliary system phenotype, macrovesicular hepatic steatosis, matted coat, microvesicular hepatic steatosis, no abnormal phenotype detected, pale liver, pancreatic islet hyperplasia, placental labyrinth hypoplasia, postnatal lethality, incomplete penetrance, premature death, premature hair loss, prenatal lethality, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, progressive hair loss, reduced female fertility, reduced fertility, renal glomerulus hypertrophy, reproductive system phenotype, sebaceous gland atrophy, skeleton phenotype, skin fibrosis, slow postnatal weight gain, thin interventricular septum, thin myocardium, thin ventricle myocardium compact layer, thin ventricular wall